Post-transcriptional & post-translational control of gene expression in the inner ear [0.03%]
耳内基因表达的转录后和翻译后调控
Brandon Cox,Bradely J Walters
Brandon Cox
Chromodomain helicase DNA binding protein 4 in cell fate decisions [0.03%]
染色体结构调节蛋白HELICASE基因在细胞命运决定中的作用机制研究
Alejandra Laureano,Jihyun Kim,Edward Martinez et al.
Alejandra Laureano et al.
Loss of spiral ganglion neurons (SGNs) in the cochlea causes hearing loss. Understanding the mechanisms of cell fate transition accelerates efforts that employ directed differentiation and lineage conversion to repopulate lost SGNs. Propose...
Shraddha A Shende,Raksha A Mudar
Shraddha A Shende
Recent evidence suggests links between hearing loss and cognitive impairment in older adults with peripheral age-related hearing loss (ARHL). Earliest cognitive changes have been observed in cognitive control; however, a cohesive account of...
Jinho Park,Jonathan E Bird
Jinho Park
Inner ear hair cells assemble mechanosensitive hair bundles on their apical surface that transduce sounds and accelerations. Each hair bundle is comprised of ∼ 100 individual stereocilia that are arranged into rows of increasing height and...
Jeffrey N Savas
Jeffrey N Savas
Orchestration of protein production and degradation and the regulation of protein lifetimes play a central role in many basic biological processes. Nearly all mammalian proteins are replenished by protein turnover in waves of synthesis and ...
Abnormal auditory brainstem responses in an animal model of autism spectrum disorder [0.03%]
自闭症谱系障碍动物模型的异常听觉脑干反应
Arjun S Malhotra,Randy Kulesza
Arjun S Malhotra
Auditory dysfunction is a common feature of autism spectrum disorder (ASD) and ranges from deafness to hypersensitivity. The auditory brainstem response (ABR) permits study of the amplitude and latency of synchronized electrical activity al...
Group I metabotropic glutamate receptor-triggered temporally patterned action potential-dependent spontaneous synaptic transmission in mouse MNTB neurons [0.03%]
小鼠MNTB神经元中I组代谢型谷氨酸受体触发的、依赖于动作电位的时间模式化自发性突触传递
Huimei Wang,Kang Peng,Rebecca J Curry et al.
Huimei Wang et al.
Rhythmic action potentials (AP) are generated via intrinsic ionic mechanisms in pacemaking neurons, producing synaptic responses of regular inter-event intervals (IEIs) in their targets. In auditory processing, evoked temporally patterned a...
Development and evaluation of helper dependent adenoviral vectors for inner ear gene delivery [0.03%]
内耳给药的辅助依赖型腺病毒载体的构建及评价
Osama Tarabichi,Tatiana Correa,Emre Kul et al.
Osama Tarabichi et al.
Viral vector gene therapy is an attractive strategy to treat hearing loss. Since hearing loss is due to a variety of pathogenic signaling cascades in distinct cells, viral vectors that can express large or multiple genes in a cell-type spec...
The effect of rhythm on selective listening in multiple-source environments for young and older adults [0.03%]
节奏对年轻和年长成人多声源环境选择性聆听的影响
Dylan V Pearson,Yi Shen,J Devin McAuley et al.
Dylan V Pearson et al.
Understanding continuous speech with competing background sounds is challenging, particularly for older adults. One stimulus property that may aid listeners understanding of to-be-attended (target) material is temporal regularity (rhythm). ...
Linear mixed-effect modeling of organ of Corti vibratory tuning curves [0.03%]
柯蒂器振动调谐曲线的线性混合效应建模方法研究
John S Oghalai
John S Oghalai
Optical coherence tomography has become the most popular approach to experimental measures of sound-induced vibrations within the mammalian cochlea. Because it is relatively easy to use and works in the unopened cochlea, the measurement of ...