Time-dependent effects of acoustic trauma and tinnitus on extracellular levels of amino acids in the inferior colliculus of rats [0.03%]
噪声损伤和耳鸣对大鼠下丘氨基酸水平影响的时效关系研究
Huey Tieng Tan,Paul F Smith,Yiwen Zheng
Huey Tieng Tan
Chronic tinnitus is a debilitating condition with very few management options. Acoustic trauma that causes tinnitus has been shown to induce neuronal hyperactivity in multiple brain areas in the auditory pathway, including the inferior coll...
Rational design of a genomically humanized mouse model for dominantly inherited hearing loss, DFNA9 [0.03%]
用于常染色体显性遗传性耳聋DFNA9合理设计基因人源化小鼠模型
Dorien Verdoodt,Erwin van Wijk,Sanne Broekman et al.
Dorien Verdoodt et al.
DFNA9 is a dominantly inherited form of adult-onset progressive hearing impairment caused by mutations in the COCH gene. COCH encodes cochlin, a crucial extracellular matrix protein. We established a genomically humanized mouse model for th...
Pharmacokinetics of monoclonal antibodies locally-applied into the middle ear of guinea pigs [0.03%]
单克隆抗体局部应用于豚鼠中耳后的药代动力学研究
Tomoko Kita,Yoshiyuki Yabe,Yuki Maruyama et al.
Tomoko Kita et al.
Countless therapeutic antibodies are currently available for the treatment of a broad range of diseases. Some target molecules of therapeutic antibodies are involved in the pathogenesis of sensorineural hearing loss (SNHL), suggesting that ...
Neural hyperactivity and altered envelope encoding in the central auditory system: Changes with advanced age and hearing loss [0.03%]
中枢听觉系统中的神经超活化和信封编码改变：高级年龄和听力损失带来的变化
Carolyn M McClaskey
Carolyn M McClaskey
Temporal modulations are ubiquitous features of sound signals that are important for auditory perception. The perception of temporal modulations, or temporal processing, is known to decline with aging and hearing loss and negatively impact ...
The scalp time-varying network of auditory spatial attention in "cocktail-party" situations [0.03%]
“鸡尾酒会”情景中听觉空间注意的头皮时变网络特性研究
Hongxing Liu,Yanru Bai,Zihao Xu et al.
Hongxing Liu et al.
Sound source localization in "cocktail-party" situations is a remarkable ability of the human auditory system. However, the neural mechanisms underlying auditory spatial attention are still largely unknown. In this study, the "cocktail-part...
Heightened OAEs in young adult musicians: Influence of current noise exposure and training recency [0.03%]
年轻成人音乐家的耳声发射增强：当前噪声暴露和训练近期性的影响
Morgan Main,Erika Skoe
Morgan Main
Otoacoustic emissions (OAEs) are a non-invasive metric of cochlear function. Studies of OAEs in musicians have yielded mixed results, ranging from evidence of diminished OAEs in musicians-suggesting noise-induced hearing loss-to no differen...
Michael Brosch,Peter Heil;all organizers
Michael Brosch
Audrey C Drotos,Michael T Roberts
Audrey C Drotos
The inferior colliculus (IC) is a critical computational hub in the central auditory pathway. From its position in the midbrain, the IC receives nearly all the ascending output from the lower auditory brainstem and provides the main source ...
Mechanisms of age-related hearing loss at the auditory nerve central synapses and postsynaptic neurons in the cochlear nucleus [0.03%]
年龄相关性听力损失在耳蜗神经元突触和核团中的机制研究
Ruili Xie,Meijian Wang,Chuangeng Zhang
Ruili Xie
Sound information is transduced from mechanical vibration to electrical signals in the cochlea, conveyed to and further processed in the brain to form auditory perception. During the process, spiral ganglion neurons (SGNs) are the key cells...
Abrupt phase changes coupled with waning in amplitude of neural oscillation lead to phase-locking in the auditory evoked responses [0.03%]
振幅减弱的神经振荡相变导致听觉诱发反应相锁定
Takashi Hamada
Takashi Hamada
Neural oscillations on the human auditory cortex measured with the magnetoencephalography were band-pass filtered between 3 and 16 Hz and then divided into instantaneous phases and amplitudes by the Hilbert transformation. Spontaneously, th...