Marie-Anick Savard,Emily B J Coffey
Marie-Anick Savard
Misophonia is a disorder in which specific common sounds such as another person breathing or chewing, or the ticking of a clock, cause an atypical negative emotional response. Affected individuals may experience anger, irritability, annoyan...
Narrow elliptical motion at the outer hair cell-Deiters' cell junction explains disparate features of uniaxial displacement measurements [0.03%]
外毛细胞-迪特尔细胞连接处的椭圆运动解释了单轴位移测量中的不同特征
Brian L Frost,C Elliott Strimbu,Elizabeth S Olson
Brian L Frost
Sound-evoked displacement responses at the outer hair cell-Deiters' cell junction (OHC-DC) are of significant interest in cochlear mechanics, as OHCs are believed to be in part responsible for active tuning enhancement and amplification. Mo...
Not-so-normal hearing: Temporary hearing changes lead to chronic difficulties for listeners with "normal" audiometric thresholds [0.03%]
看似正常的听力问题：短暂的听力变化导致“正常”听阈听众的慢性困难
Douglas S Brungart,Gregory M Ellis,Alyssa Davidson et al.
Douglas S Brungart et al.
Hearing loss has historically been mainly associated with elevated pure-tone thresholds. However, in recent years, there has been increased interest in addressing the hearing difficulties reported by individuals with normal hearing threshol...
Hemispheric difference of adaptation lifetime in human auditory cortex measured with MEG [0.03%]
基于MEG的人耳语区适应持续时间的半球差异研究
Asim H Dar,Nina Härtwich,Aida Hajizadeh et al.
Asim H Dar et al.
Adaptation is the attenuation of a neuronal response when a stimulus is repeatedly presented. The phenomenon has been linked to sensory memory, but its exact neuronal mechanisms are under debate. One defining feature of adaptation is its li...
Extent of genetic and epigenetic factor reprogramming via a single viral vector construct in deaf adult mice [0.03%]
通过单一病毒载体构建在聋成年小鼠中实现遗传和表观遗传因素重编程的程度
Niliksha Gunewardene,Patrick Lam,Jiwei Song et al.
Niliksha Gunewardene et al.
In the adult mammalian cochlea, hair cell loss is irreversible and causes deafness. The basic helix-loop transcription factor Atoh1 is essential for normal hair cell development in the embryonic ear. Over-expression of Atoh1 in the adult co...
Gonad-derived steroid hormones mediate a sex difference in the maturation of auditory encoding in the cochlea from adolescence to early adulthood in C57BL/6J mice [0.03%]
青春期至成年早期小鼠耳蜗听觉编码的成熟存在性别二态性且与性腺源类固醇激素有关
Nicholas R Lozier,Max A Aizenstein,Essence D Williams et al.
Nicholas R Lozier et al.
Sexually mature females of multiple mammalian species were previously reported to have increased peripheral auditory sensitivity, often measured as higher auditory brainstem response (ABR) wave I amplitude compared to males. Here, we determ...
Robert Fettiplace,Maryline Beurg
Robert Fettiplace
We developed an isolated auditory papilla of the crested gecko to record from the hair cells and explore the origins of frequency tuning. Low-frequency cells displayed electrical tuning, dependent on Ca2+-activated K+ channels; high-frequen...
Administration of nicotinamide mononucleotide suppresses the progression of age-related hearing loss in mice [0.03%]
烟酰胺单核苷酸的给药可抑制小鼠年龄相关性听力损失的发展
Kouya Hattori,Takashige Hamaguchi,Rika Azuma-Suzuki et al.
Kouya Hattori et al.
Age-related hearing loss (ARHL) is a widespread problem in the elderly, significantly impairing their quality of life. Despite its high prevalence, no fundamental treatment for ARHL has been established. Nicotinamide adenine dinucleotide (N...
Cochlear Amplification in the Short-Wave Region by Outer Hair Cells changing Organ-of-Corti area to Amplify the Fluid Traveling Wave [0.03%]
通过外毛细胞改变科蒂器官面积放大短波区域耳蜗放大效应
John J Guinan Jr
John J Guinan Jr
Many details of the operation of the mammalian cochlea are known, but how they all work together to produce cochlear amplification is not understood. Outer-hair-cell (OHC) motility produces two kinds of amplification: non-propagating amplif...
Alterations in brain activity and functional connectivity originating residual inhibition of tinnitus induced by tailor-made notched music training [0.03%]
个性化缺口音乐训练诱导的残余抑制与大脑活动和功能连接的变化关系研究
Min Zhu,Qin Gong
Min Zhu
Tinnitus arises from the intricate interplay of multiple, parallel but overlapping networks, involving neuroplastic changes in both auditory and non-auditory activity. Tailor-made notched music training (TMNMT) has emerged as a promising th...