Sex-specific hearing loss in Sirt3 knockout mice and attenuation by honokiol [0.03%]
敲除Sirt3小鼠的性别特异性听力损失及其通过honokiol缓解的效果
Chail Koo,Yingjie Zhou,Devin Thomas et al.
Chail Koo et al.
Sirtuin 3 (SIRT3) is a mitochondrial deacetylase that regulates redox balance and cellular stress resistance. Its role in hearing maintenance under basal conditions is controversial. Here, we investigated the effect of Sirt3 deficiency on a...
Finite-element modelling of the 3D motion of the malleus-incus complex validated with 3D laser Doppler vibrometry [0.03%]
有限元法模拟锤骨和砧骨三维运动的模型并通过激光多普勒 Vibrometry 法进行验证
Pieter G G Muyshondt,Lukas Prochazka,Merlin Schär et al.
Pieter G G Muyshondt et al.
Three-dimensional (3D) motions of the middle ear (ME) are investigated with finite-element (FE) modelling by comparison with 3D laser Doppler vibrometer (LDV) measurements of the malleus-incus complex. 3D point velocity measurements are con...
Validating a rapid psychophysical procedure for estimating interaural time difference thresholds [0.03%]
验证用于估计耳间时间差阈值的快速心理物理学程序的有效性
Justin M Aronoff,Jordan Deutsch,Josephine R LaPapa et al.
Justin M Aronoff et al.
The detection and discrimination of interaural time differences (ITDs) underpin many binaural abilities. Obtaining precise "threshold"-ITDs is, however, often quite time consuming. This study investigated the use of a rapid, descending seri...
Automated high-fidelity 3D reconstruction of middle-ear ossicles from low-resolution clinical CT using a deep learning pipeline [0.03%]
基于深度学习的管道使用低分辨率临床CT自动高保真重建中耳听小骨
Jongyeon Yoon,Jeongsan Kim,Jongwoo Lim et al.
Jongyeon Yoon et al.
This study validates an automated deep learning framework for generating high-fidelity 3D models of the middle-ear ossicles from low-resolution clinical CT images. The framework employs a sequential three-stage pipeline: (1) accurate Region...
Evidence for evolutionary divergence in temporal integration windows between human and monkey auditory cortex [0.03%]
人类和猴听觉皮层在时间整合窗口进化分歧的证据
Pradeep Dheerendra,Christopher I Petkov,Adrian Rees et al.
Pradeep Dheerendra et al.
The cortical representation of the temporal dimension of sound in the primate auditory cortex remains an open question. In this work, we review studies that investigated the brain basis for the processing of acoustic time windows in humans,...
Smoking history and the rate of hearing decline in aging: Results from a longitudinal cohort study [0.03%]
吸烟史与老龄化过程中听觉下降速度的关系——一项纵向队列研究的结果
Lauren K Dillard,Lois J Matthews,Kathleen E Bainbridge et al.
Lauren K Dillard et al.
Hearing loss is a common and impactful condition among aging adults. Improved understanding of modifiable risk factors for hearing loss, including smoking, could promote hearing loss prevention. The purpose of this longitudinal study was to...
Impaired prepulse inhibition in APP/PS1 mice is accompanied by substantial morphological changes in neurons of the central auditory system and hippocampus [0.03%]
APP/PS1小鼠听觉中枢和海马神经元结构改变导致prepulse抑制效应受损
Jana Svobodová Burianová,Daniela Černotová,Tereza Klausová et al.
Jana Svobodová Burianová et al.
Auditory dysfunction is increasingly recognized as a non-cognitive feature of Alzheimer's disease (AD). We examined auditory processing and neuronal morphology in APPswe/PSEN1dE9 (APP/PS1) transgenic mice, a model of AD. Ten-month-old male ...
Validating and refining a psychoacoustic test to diagnose hyperacusis [0.03%]
验证和细化用于诊断响度过敏的psychoacoustic测试
Philippe Fournier,Pierre H Bourez,Anne-Sophie Côté et al.
Philippe Fournier et al.
Decreased sound tolerance refers to conditions like hyperacusis and misophonia, in which everyday sounds may provoke discomfort or distress. Hyperacusis is characterized by exaggerated loudness perception and aversive reactions to moderate ...
A case of acquired amusia and misophonia following right temporal resection [0.03%]
右颞叶切除术后的获得性音盲和恐音症病例报告
Emily R Dappen,Joel I Berger,Amy M Belfi et al.
Emily R Dappen et al.
Background: Our perception of the auditory world allows us to enjoy the richness of music and communicate effectively with others. These everyday processes are disrupted in conditions such as amusia, an inability to perce...
Impact of age and sensorineural hearing loss on sound transmission to the inner ear based on analysis of air-bone gaps [0.03%]
基于空-骨导差值分析年龄和神经感觉性听力损失对内耳声传输的影响
Stefan Stenfelt,Filip Wiman
Stefan Stenfelt
Air-bone gaps (ABGs) provide a clinical marker of middle ear transmission efficiency, yet their dependence on age and sensorineural hearing loss remains unclear. We retrospectively analyzed 24,570 audiograms (13,417 patients, 4-102 years) c...