Distinct cell classes in the superior paraolivary nucleus (SPN) region in the gerbil auditory brainstem revealed by in vivo physiological and anatomical characterization [0.03%]
基于体内生理学和形态学特征的gerbil听觉脑干中上外侧橄榄核区域不同细胞类型的研究
T P Franken,P X Joris,P H Smith
T P Franken
The superior para-olivary nucleus (SPN or SPON) is a prominent nucleus in the superior olivary complex of the auditory brainstem. The cellular composition of the nucleus reportedly differs between species, but a prominent recurring feature ...
Convergent validity of cortical auditory evoked potential indices of central auditory nervous system inhibition in people with and without tinnitus [0.03%]
耳鸣患者和非耳鸣者中枢听觉神经系统的抑制指标的皮层听觉诱发电位的汇聚效度
Kenneth Morse,Leah Morse
Kenneth Morse
Tinnitus is the perception of a ringing, buzzing, or other sound without the presence of an external stimulus. Reduced central auditory nervous system inhibition is a commonly reported mechanism contributing to a person's tinnitus perceptio...
Rational design of a Lfng-enhancer AAV construct drives specific and efficient gene expression in inner ear supporting cells [0.03%]
合理设计的Lfng增强剂AAV构架能在内耳支撑细胞中驱动特异而高效的基因表达
Richard Seist,Juwan S Copeland,Litao Tao et al.
Richard Seist et al.
Achieving cell-specific gene expression is crucial in the design of safe and efficacious gene therapies for the treatment of sensorineural hearing loss. Although a variety of adeno-associated virus (AAV) serotypes have been used to deliver ...
Perilymph sampling in Mongolian gerbil, technical note and procedure evaluation [0.03%]
蒙古沙鼠迷路外液采样方法及技术评价
Claire Olivier,Cyril Beck,Michaël Risoud et al.
Claire Olivier et al.
Objective: The aim of this study is to detail and evaluate the surgical procedure for perilymph sampling from the cochlear apex in the Mongolian gerbil. D...
Marie-Anick Savard,Emily B J Coffey
Marie-Anick Savard
Misophonia is a disorder in which specific common sounds such as another person breathing or chewing, or the ticking of a clock, cause an atypical negative emotional response. Affected individuals may experience anger, irritability, annoyan...
Narrow elliptical motion at the outer hair cell-Deiters' cell junction explains disparate features of uniaxial displacement measurements [0.03%]
外毛细胞-迪特尔细胞连接处的椭圆运动解释了单轴位移测量中的不同特征
Brian L Frost,C Elliott Strimbu,Elizabeth S Olson
Brian L Frost
Sound-evoked displacement responses at the outer hair cell-Deiters' cell junction (OHC-DC) are of significant interest in cochlear mechanics, as OHCs are believed to be in part responsible for active tuning enhancement and amplification. Mo...
Not-so-normal hearing: Temporary hearing changes lead to chronic difficulties for listeners with "normal" audiometric thresholds [0.03%]
看似正常的听力问题：短暂的听力变化导致“正常”听阈听众的慢性困难
Douglas S Brungart,Gregory M Ellis,Alyssa Davidson et al.
Douglas S Brungart et al.
Hearing loss has historically been mainly associated with elevated pure-tone thresholds. However, in recent years, there has been increased interest in addressing the hearing difficulties reported by individuals with normal hearing threshol...
Hemispheric difference of adaptation lifetime in human auditory cortex measured with MEG [0.03%]
基于MEG的人耳语区适应持续时间的半球差异研究
Asim H Dar,Nina Härtwich,Aida Hajizadeh et al.
Asim H Dar et al.
Adaptation is the attenuation of a neuronal response when a stimulus is repeatedly presented. The phenomenon has been linked to sensory memory, but its exact neuronal mechanisms are under debate. One defining feature of adaptation is its li...
Extent of genetic and epigenetic factor reprogramming via a single viral vector construct in deaf adult mice [0.03%]
通过单一病毒载体构建在聋成年小鼠中实现遗传和表观遗传因素重编程的程度
Niliksha Gunewardene,Patrick Lam,Jiwei Song et al.
Niliksha Gunewardene et al.
In the adult mammalian cochlea, hair cell loss is irreversible and causes deafness. The basic helix-loop transcription factor Atoh1 is essential for normal hair cell development in the embryonic ear. Over-expression of Atoh1 in the adult co...
Gonad-derived steroid hormones mediate a sex difference in the maturation of auditory encoding in the cochlea from adolescence to early adulthood in C57BL/6J mice [0.03%]
青春期至成年早期小鼠耳蜗听觉编码的成熟存在性别二态性且与性腺源类固醇激素有关
Nicholas R Lozier,Max A Aizenstein,Essence D Williams et al.
Nicholas R Lozier et al.
Sexually mature females of multiple mammalian species were previously reported to have increased peripheral auditory sensitivity, often measured as higher auditory brainstem response (ABR) wave I amplitude compared to males. Here, we determ...