Pbx1 overexpression delays cochlear hair cells degeneration in an accelerated aging mouse model [0.03%]
Pbx1过表达延缓加速老化小鼠耳蜗毛细胞退变
Ruihan Zhu,Gaogan Jia,Yiming Shen et al.
Ruihan Zhu et al.
Age-related hearing loss (ARHL), the most prevalent sensory disorder worldwide, arises primarily from cochlear hair cells (HCs) degeneration due to aging. Although the molecular mechanisms driving HC senescence are increasingly understood, ...
Noise exposure induces autophagy-modulated nuclear-to-cytoplasmic translocation of TDP-43 in spiral ganglion neurons [0.03%]
噪声暴露通过自噬调节TDP-43从螺旋神经节神经元细胞核向胞浆的易位
Rong Han,Yefei Mo,Lingxiao Jiang et al.
Rong Han et al.
Noise exposure contributes to approximately one-third of hearing loss cases worldwide. Despite its substantial global burden, noise-induced hearing loss (NIHL) remains essentially irreversible, largely because its underlying pathogenic mech...
Chronic salicylate administration induces transcriptomic and metabolomic remodeling in the rat cochlear nucleus and hippocampus [0.03%]
慢性水杨酸给药诱导大鼠耳蜗核和海马的转录组和代谢组重塑
Shichu Sun,Shuai Cheng,Shifu Li et al.
Shichu Sun et al.
Salicylate reliably induces tinnitus, yet its systemic effects on the central auditory and limbic systems remain incompletely characterized. Through integrated transcriptomic and metabolomic profiling of the rat cochlear nucleus and hippoca...
A primate model revealed specific age-related changes in spiral ganglion neurons in the cochlea [0.03%]
恒河猴耳蜗螺旋神经元的年龄相关变化模式研究
Masafumi Ueno,Makoto Hosoya,Marie N Shimanuki et al.
Masafumi Ueno et al.
Type I spiral ganglion neurons, which play a major role in hearing by conveying electrical sound signals to the brain, are divided into electrophysiological and molecular subtypes. The differences in vulnerability among the subtypes reporte...
EEG-based decoding of auditory attention to conversations with turn-taking speakers [0.03%]
基于 EEG 的对话轮换听觉注意力解码
Iris Van de Ryck,Nicolas Heintz,Iustina Rotaru et al.
Iris Van de Ryck et al.
Objectives: Auditory attention decoding (AAD) refers to the process of identifying which sound source a listener is attending to, based on neural recordings, such as electroencephalography (EEG). Most AAD studies use a co...
David K Ryugo,Satoshi Nishitani
David K Ryugo
Age-related hearing loss impairs speech understanding for socialization and music appreciation for enjoyment, both of which compromise quality of life and can lead to cognitive decline. It has previously been shown that while standard audio...
Effects of early childhood otitis media-related conductive hearing loss on speech perception, neural processing, and working memory [0.03%]
儿童期分泌性中耳炎引起的传导性听力损失对语音感知、神经处理和工作记忆的影响
Anadel Khalaila-Zbidat,Arie Gordin,Hanin Karawani
Anadel Khalaila-Zbidat
Otitis media with effusion (OME) is a common childhood ear disease that can cause temporary conductive hearing loss during a critical period of auditory development. This condition is hypothesized to be related to deficits in neural, percep...
New concept for mechanisms of hair cell regeneration in the chick auditory epithelium [0.03%]
鸡 auditory 上皮中毛细胞再生机制的新概念
Marie Takeuchi,Mami Matsunaga,Takayuki Nakagawa
Marie Takeuchi
Sensory hair cells in the cochlea are essential for hearing. In adult mammals, hair cells are incapable of regeneration, primarily because the supporting cells lose their regenerative capacity shortly after birth. In contrast, avian support...
Furosemide prevents noise-induced hearing loss and enhances the preventive effect of N-acetylcysteine [0.03%]
呋塞米可预防噪声性听力损失并增强N-乙酰半胱氨酸的防护作用
Hongguo Su,Fan Wu,Khujista Haque et al.
Hongguo Su et al.
Disruption of reactive oxygen species (ROS) homeostasis is a key mechanism underlying noise-induced sensory hair cell damage. Antioxidant treatments such as N-acetylcysteine (NAC) have been shown to attenuate noise-induced hearing loss (NIH...
Primary and nonprimary auditory cortex connectivity with brain regions involved in cognitive and emotional processing: in mouse and human [0.03%]
与参与认知和情绪处理的大脑区域连接的初级和非初级听觉皮层：从小鼠到人类
Büşra Köse-Özkan,Mazhar Özkan,Yasin Celal Güneş et al.
Büşra Köse-Özkan et al.
Auditory cortex connectivity extends beyond the processing of acoustic stimuli, playing a crucial role in cognitive and emotional regulation through its interactions with higher-order brain regions. Although the neural mechanisms underlying...