Siân Culley,Kalina L Tosheva,Pedro Matos Pereira et al.
Siân Culley et al.
Super-resolution microscopy techniques break the diffraction limit of conventional optical microscopy to achieve resolutions approaching tens of nanometres. The major advantage of such techniques is that they provide resolutions close to th...
A K Eichelmann,C Matuszcak,R Hummel et al.
A K Eichelmann et al.
The tumor microenvironment (TME) of cancer cells is regarded as a strong determinant for cancer development and acquisition of metastatic potential of cancer cells. Because of its influence on tumorigenesis, the TME increasingly gained atte...
Identification and application of self-binding zipper-like sequences in SARS-CoV spike protein [0.03%]
SARS-CoV刺突蛋白中自结合拉链样序列的鉴定及应用
Si Min Zhang,Ying Liao,Tuan Ling Neo et al.
Si Min Zhang et al.
Self-binding peptides containing zipper-like sequences, such as the Leu/Ile zipper sequence within the coiled coil regions of proteins and the cross-β spine steric zippers within the amyloid-like fibrils, could bind to the protein-of-origi...
Cellular fluorescein hyperfluorescence is dynamin-dependent and increased by Tetronic 1107 treatment [0.03%]
细胞荧光素过度荧光现象由动力蛋白介导并可通过 Tetronic 1107 处理增强
Tahmina F Khan,Bianca L Price,Philip B Morgan et al.
Tahmina F Khan et al.
Sodium fluorescein ('fluorescein') staining of the ocular surface is frequently an indicator of compromised ocular health, and increases in the presence of certain contact lens multi-purpose solutions (MPS), a phenomenon known as solution i...
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells [0.03%]
一种类似于蜂毒肽的类肽化合物MEL-pep可破坏细胞膜并逆转人肝癌细胞对氟尿嘧啶的耐药性
Mengyun Ke,Jian Dong,Yue Wang et al.
Mengyun Ke et al.
Chemotherapy resistance represents a major obstacle in the treatment of patients with hepatocellular carcinoma (HCC). The purpose of this study was to investigate the anti-cancer effect of MEL-pep, a novel analog of the natural antibacteria...
LncRNA TUG1 interacting with miR-144 contributes to proliferation, migration and tumorigenesis through activating the JAK2/STAT3 pathway in hepatocellular carcinoma [0.03%]
长链非编码RNA TUG1通过与miR-144互作激活JAK2 / STAT3通路促进肝癌细胞增殖、迁移及成瘤性
Jun Lv,Yongkui Kong,Zhiqiang Gao et al.
Jun Lv et al.
Recently, it is reported that taurine upregulated gene 1 (TUG1) participates in the tumor progression by acting as a competing endogenous RNA (ceRNA) of miRNAs. Nonetheless, whether TUG1 could serve as a ceRNA of miR-144 in hepatocellular c...
Saife Niaz,Mahboob Ul Hussain
Saife Niaz
GW182 proteins interact directly with the argonaute proteins and constitute key components of miRNA repressor complexes (miRISC) in metazoans. As argonautes are insufficient for silencing they recruit the GW182 s that act as scaffold protei...
Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity [0.03%]
具有促凝活性的脂肪来源间充质干细胞外泌体
Tomas Fiedler,Magdalena Rabe,Ralf G Mundkowski et al.
Tomas Fiedler et al.
Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cel...
RT-qPCR analysis of human melanoma progression-related genes - A novel workflow for selection and validation of candidate reference genes [0.03%]
人类黑色素瘤进展相关基因的RT-qPCR分析-选择和验证候选参考基因的新工作流程
Marcelina E Janik,Sabina Szwed,Paweł Grzmil et al.
Marcelina E Janik et al.
The objective of this study was to identify a normalizer or combination of normalizers for quantitative evaluation of the expression of a target gene of interest during melanoma progression. Adult melanocytes, uveal primary melanoma cells a...
MiR-128-3p directly targets VEGFC/VEGFR3 to modulate the proliferation of lymphatic endothelial cells through Ca2+ signaling [0.03%]
miR-128-3p通过Ca2+信号直接靶向VEGFC/VEGFR3调节淋巴内皮细胞的增殖
Jie Zhou,Zhiyou He,Le Guo et al.
Jie Zhou et al.
Lymphangiogenesis has been regarded as a physiological response to pathologic stimuli. The abnormal proliferation of lymphatic endothelial cell (LECs) and lymphangiogenesis is involved in the development of lymphatic disorders. Reportedly, ...