Hans Zischka,Claudia Einer
Hans Zischka
In mitochondria, copper is a Janus-faced trace element. While it is the essential cofactor of the mitochondrial cytochrome c oxidase, a surplus of copper can be highly detrimental to these organelles. On the one hand, mitochondria are stric...
Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking [0.03%]
表亲携手合作：医学与光学影像技术联用如何增强在体细胞追踪效果
Alessia Volpe,Ewelina Kurtys,Gilbert O Fruhwirth
Alessia Volpe
Microscopy and medical imaging are related in their exploitation of electromagnetic waves, but were developed to satisfy differing needs, namely to observe small objects or to look inside subjects/objects, respectively. Together, these tech...
MicroRNA-17 inhibition overcomes chemoresistance and suppresses epithelial-mesenchymal transition through a DEDD-dependent mechanism in gastric cancer [0.03%]
微小核糖核酸-17抑制可克服化学耐药性并通过DEDD依赖机制在胃癌中抑制上皮间充质转化
Dong-Mei Wu,Xiao-Wu Hong,Ling-Ling Wang et al.
Dong-Mei Wu et al.
MicroRNAs (miRNAs), a novel class of important gene-regulatory molecules, correlates with tumor growth, invasion, metastasis, and chemo resistance in gastric cancer (GC). Microarray analysis revealed that aberrant expressed microRNA-17 (miR...
Telmisartan generates ROS-dependent upregulation of death receptor 5 to sensitize TRAIL in lung cancer via inhibition of autophagy flux [0.03%]
替米沙坦通过抑制自噬使肺癌细胞增敏并诱导凋亡受体依赖的TRAIL死亡信号途径
Mohammad Rasheduzzaman,Ji-Hong Moon,Ju-Hee Lee et al.
Mohammad Rasheduzzaman et al.
Telmisartan broadly used for the treatment of hypertension that is also known for its anticancer properties. TRAIL has the potential to kill tumor cells with minimal toxicity in normal cells by binding to death receptors, DR4 and DR5. Unfor...
Peroxiredoxin 5 prevents iron overload-induced neuronal death by inhibiting mitochondrial fragmentation and endoplasmic reticulum stress in mouse hippocampal HT-22 cells [0.03%]
过氧化氢酶素5通过抑制线粒体碎裂和内质网压力来预防铁过载诱导的神经元死亡：小鼠海马HT-22细胞中的作用机制研究
Dong Gil Lee,Min Kyoung Kam,Kyung Min Kim et al.
Dong Gil Lee et al.
Iron is an essential element for neuronal as well as cellular functions. However, Iron overload has been known to cause neuronal toxicity through mitochondrial fission, dysregulation of Ca2+, endoplasmic reticulum (ER) stress, and reactive ...
Mixomics analysis of breast cancer: Long non-coding RNA linc01561 acts as ceRNA involved in the progression of breast cancer [0.03%]
乳腺癌的混合组学分析：长链非编码RNA linc01561充当ceRNA参与乳腺癌进展
Rui Jiang,Chunming Zhao,Binbin Gao et al.
Rui Jiang et al.
Objective: This study aimed at finding the long non-coding RNA (lncRNA), miRNA and mRNA which played critical roles in breast cancer (BrCa) by using mixOmics R package. ...
MiR-208a enhances cell proliferation and invasion of gastric cancer by targeting SFRP1 and negatively regulating MEG3 [0.03%]
miR-208a通过靶向SFRP1并抑制MEG3促进胃癌细胞增殖和侵袭
Hai-Bin Cui,Huai-E Ge,Yong-Sen Wang et al.
Hai-Bin Cui et al.
The present studies have identified that microRNAs function as regulators in different diseases including cancers. However, the expression patterns and underlying molecular mechanisms of miR-208a involved in gastric cancer (GC) remain littl...
Biqin Dong,Janel L Davis,Cheng Sun et al.
Biqin Dong et al.
The recent surge in spectroscopic Single-Molecule Localization Microscopy (sSMLM) offers exciting new capabilities for combining single molecule imaging and spectroscopic analysis. Through the synergistic integration of super-resolution opt...
Mohammed A Mansour
Mohammed A Mansour
Dynamic modulation and posttranslational modification of proteins are tightly controlled biological processes that occur in response to physiological cues. One such dynamic modulation is ubiquitination, which marks proteins for degradation ...
Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107 [0.03%]
通过抑制MTORC1信号延迟内皮细胞复制性衰老涉及MicroRNA-107
Eng-Soon Khor,Pooi-Fong Wong
Eng-Soon Khor
Accumulation of senescent endothelial cells can contribute to endothelium dysfunction. Suppression of MTOR signaling has been shown to delay senescence but the mechanism that underpins this effect, particularly one that involves miRNAs, rem...