Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells [0.03%]
乙酰化Siah2通过下调测试和肌动蛋白结合蛋白C来增加幽门螺杆菌感染的胃癌细胞侵袭性
Shrikant Babanrao Kokate,Pragyesh Dixit,Indrajit Poirah et al.
Shrikant Babanrao Kokate et al.
Helicobacter pylori is the strongest known risk-factor for gastric cancer. However, its role in gastric cancer metastasis remains unclear. Previously we have reported that H. pylori promotes gastric cancer invasiveness by stabilizing the E3...
The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4 [0.03%]
可溶性nectin-4细胞外结构城通过内皮Integrin-β4促进乳腺癌诱导的血管生成
Sumit Siddharth,Anmada Nayak,Sarita Das et al.
Sumit Siddharth et al.
Cancer stem cells secrete diffusible factors into the microenvironment that bind to specific endothelial cell receptors and initiate an angiogenesis cascade. Tumor-induced angiogenesis is an important parameter of tumorigenesis and is criti...
Xin Zhao,Yongcai Qi,Ruokun Yi et al.
Xin Zhao et al.
Bamboo salt is generated by baking bamboo and sea salt and is used as a traditional food or medicine. The aim of this study was to investigate the anti-ageing skin effects of Korean bamboo salt and to compare the antioxidant, anti-ageing an...
SNORA42 enhances prostate cancer cell viability, migration and EMT and is correlated with prostate cancer poor prognosis [0.03%]
SNORA42通过增强前列腺癌细胞活力、迁移和上皮间质转化与前列腺不良预后相关
Chuanyou Yi,Xuechao Wan,Yufeng Zhang et al.
Chuanyou Yi et al.
Prostate cancer (PCa) is one of the most common invasive cancers and the second leading cause of cancer-related death in male worldwide, reflecting the needs of diagnostic and prognostic biomarkers for PCa. Emerging evidence has revealed sm...
Upregulation of EphB3 in gastric cancer with acquired resistance to a FGFR inhibitor [0.03%]
胃癌获得性成纤维细胞生长因子受体抑制剂耐药相关的EphB3上调
Suk-Young Lee,Yoo Jin Na,Yoon A Jeong et al.
Suk-Young Lee et al.
Amplification of fibroblast growth factor receptor2 (FGFR2) has been regarded as a druggable target in gastric cancer (GC). Despite known potential of AZD4547, a selective inhibitor of FGFR 1-3, to suppress tumorigenic effects of activated ...
Alexey V Zamaraev,Gelina S Kopeina,Jörn H Buchbinder et al.
Alexey V Zamaraev et al.
The role of caspase-2 in cell death regulation remains largely unknown. In this study we have analyzed the involvement of caspase-2 in RIPK1-regulated necrosis (necroptosis) in human ovarian carcinoma cells. We show that these cells undergo...
Characterization of a novel endogenous cysteine proteinase inhibitor, trichocystatin-3 (TC-3), localized on the surface of Trichomonas vaginalis [0.03%]
表征新型内源性半胱氨酸蛋白酶抑制剂毛滴虫孢子囊素-3(TC-3)并定位其在毛滴虫表面的位置分布
Diana Belén Sánchez-Rodríguez,Jaime Ortega-López,Rosa Elena Cárdenas-Guerra et al.
Diana Belén Sánchez-Rodríguez et al.
Trichomonas vaginalis is a flagellated protist responsible for human trichomoniasis. T. vaginalis has three genes encoding for endogenous cysteine proteinase (CP) inhibitors, known as trichocystatin-1 through trichocystatin-3 (TC-1, TC-2, a...
Molecular and in silico analyses validates pathogenicity of homozygous mutations in the NPR2 gene underlying variable phenotypes of Acromesomelic dysplasia, type Maroteaux [0.03%]
分子和计算机模拟分析证实NPR2基因的纯合突变可导致马罗图瓦型肢骨-间骨发育不全的多种表型并确定其致病性
Irfanullah,Amir Zeb,Naila Shinwari et al.
Irfanullah et al.
Homozygous and/or heterozygous loss of function mutations in the natriuretic peptide receptor B (NPR2) have been reported in causing acromesomelic dysplasia, type Maroteaux with variable clinical features and idiopathic short stature with n...
Khanmi Kasomva,Arnab Sen,Michael Gabriel Paulraj et al.
Khanmi Kasomva et al.
MicroRNAs are non-coding RNA which functions as regulators of genes expression. MicroRNAs have shown their biological functions in cell proliferation, cell cycle, cell metabolism, apoptosis, invasion and metastasis. Cancer cells have the ab...
DNMT and HDAC inhibitors together abrogate endotoxemia mediated macrophage death by STAT3-JMJD3 signaling [0.03%]
DNA甲基化酶和组蛋白去乙酰化酶抑制剂通过STAT3-JMJD3信号通路协同消除内毒素介导的巨噬细胞死亡
Saheli Samanta,Zhigang Zhou,Sheeja Rajasingh et al.
Saheli Samanta et al.
Acute lung injury (ALI) is a common complication of sepsis that often leads to fatal lung disease without effective therapies. It is known that bone marrow derived macrophages are important in resolving the inflammation and maintaining tiss...