Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development [0.03%]
kindlin-2通过与DNA甲基转移酶1相互作用来稳定DNMT1以促进乳腺癌发生发展
Peng Wang,Wenhui Chu,Xi Zhang et al.
Peng Wang et al.
Integrin-interacting protein Kindlin-2, as a focal adhesion protein, promotes growth and progression of breast cancer. However, the precise mechanism that underlie the role of Kindlin-2 in breast cancer is elusive. Here, we report that the ...
Control of mRNA splicing by noncoding intragenic RNA elements that evoke a cellular stress response [0.03%]
非编码内含子RNA元件通过诱发细胞热休克反应调控信使RNA剪接事件
Raymond Kaempfer,Lise Sarah Namer,Farhat Osman et al.
Raymond Kaempfer et al.
Once activated by double-helical RNA, mammalian RNA-dependent stress protein kinase, PKR, phosphorylates its substrate, translation initiation factor eIF2α, to inhibit translation. eIF2α phosphorylation is critical for mounting a cellular...
Hypoxia-induced autophagy promotes EGFR loss in specific cell contexts, which leads to cell death and enhanced radiosensitivity [0.03%]
缺氧诱导的自噬在特定细胞环境下促进EGFR丢失，导致细胞死亡和放射敏感性增强
Baocai Liu,Dongmei Han,Tingting Zhang et al.
Baocai Liu et al.
Treatment failure through radioresistance of tumors is associated with activation of the epidermal growth factor receptor (EGFR). Tumor cell proliferation, DNA-repair, hypoxia and metastases-formation are four mechanisms in which EGFR signa...
Chemical chaperone-conjugated exendin-4 as a cytoprotective agent for pancreatic β-cells [0.03%]
用于胰腺β细胞的细胞保护剂：共轭化学分子伴侣的艾塞那肽
Sohee Son,Eun Ji Park,Yejin Kim et al.
Sohee Son et al.
Endoplasmic reticulum stress has been considered a major cause of pancreatic β-cell dysfunction and apoptosis leading to diabetes. Glucagon-like peptide-1 receptor activation and chemical chaperones have been known to reduce endoplasmic re...
Dynasore-induced potent ubiquitylation of the exon 19 deletion mutant of epidermal growth factor receptor suppresses cell growth and migration in non-small cell lung cancer [0.03%]
Dynasore通过增强泛素化作用抑制表皮生长因子受体外显子19缺失突变体促进非小细胞肺癌细胞增殖和迁移
Taishu Wang,Duchuang Wang,Yue Zhang et al.
Taishu Wang et al.
Lung cancer is a leading cause of death worldwide, with mutations in EGFR frequently detected that render this receptor tyrosine kinase constantly active. Targeted therapy against EGFR has proved effective in lung cancer treatment, but seco...
Arman Akşit,Ida J van der Klei
Arman Akşit
Peroxisomes are single membrane enclosed cell organelles, which are present in almost all eukaryotic cells. In addition to the common peroxisomal pathways such as β-oxidation of fatty acids and decomposition of H2O2, these organelles fulfi...
LncRNA FAL1 promotes carcinogenesis by regulation of miR-637/NUPR1 pathway in colorectal cancer [0.03%]
长链非编码RNA FAL1通过调节miR-637/NUPR1通路促进结直肠癌的发生发展
Liqiang Wang,Fuquan Jiang,Xiaopu Xia et al.
Liqiang Wang et al.
LncRNA FAL1 has been demonstrated to play an important role in promoting carcinogenesis via the ceRNA mechanism in several types of cancer. However, the role and the mechanism of lncRNA FAL1 in CRC remain unclear. Here our results demonstra...
Nurr1 exacerbates cerebral ischemia-reperfusion injury via modulating YAP-INF2-mitochondrial fission pathways [0.03%]
Nurr1通过调节YAP-INF2线粒体分裂信号通路加重脑缺血再灌注损伤
Zhanwei Zhang,Jianbai Yu
Zhanwei Zhang
Nurr1, a nuclear transcription factor, has been linked to ischemia-reperfusion injury (IRI) in heart and kidney via modulating mitochondrial homeostasis. However, its role in cerebral ischemia-reperfusion has not been defined. In the presen...
Topotecan prevents hypoxia-induced pulmonary arterial hypertension and inhibits hypoxia-inducible factor-1α and TRPC channels [0.03%]
托泊替康可预防缺氧诱导的肺动脉高压并抑制缺氧诱导因子-1α和瞬时受体电位通道
Yongliang Jiang,Yumin Zhou,Gongyong Peng et al.
Yongliang Jiang et al.
Background: This study aimed to investigate the effects of topotecan (TPT) on the hypoxia-induced pulmonary arterial hypertension (PAH) in a rat model, and to explore the underlying mechanism. ...