Integrated Bulk and Single-Cell RNA Sequencing Identifies Oxidative Stress Signatures of Radiation-Induced Lung Injury in Mice through Machine Learning [0.03%]
整合bulk和单细胞RNA测序通过机器学习鉴定小鼠放射诱导肺损伤的氧化应激标志物
Wei Huang,Guanhua Deng,Qinghua Zhang et al.
Wei Huang et al.
Background: Radiation induced lung injury (RILI) is a common complication in patients undergoing thoracic radiotherapy. At present, there are no effective early diagnostic biomarkers, and clinical treatment methods are ve...
Corrigendum to "Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death" [Int. J. Biochem. Cell Biol. 44 (2012) 1622-1631] [0.03%]
“小分子热休克蛋白HSP27(HspB1)，αB-晶状体蛋白(HspB5)和HSP22(HspB8)在细胞凋亡中的调控作用”一文的勘误通知(Int.J.Biochem.Cell Biol. 44 (2012) 1622-1631)
Julie Acunzo,Maria Katsogiannou,Palma Rocchi
Julie Acunzo
Resistance to silicosis progression in mice with Ch25h downregulation: The involvement of NLRP3 inflammasome [0.03%]
下调Ch25h小鼠抵抗硅肺进展的作用及NLRP3炎症小体的参与
Meiqi Sun,Hua Fang,Jiashu Zhang et al.
Meiqi Sun et al.
Silicosis is a fatal occupational lung disease characterized by persistent inflammation and irreversible fibrosis. However, the pathogenesis of silicosis is currently unclear. In this study, a mouse model of silicosis was established by int...
Syndecan-2 positively regulates Wnt/β-catenin signaling in breast cancer cells [0.03%]
syndecan-2在乳腺癌细胞中正向调节Wnt/β-catenin信号通路
Leyli Naraghi,Alexey Koval,Vladimir L Katanaev et al.
Leyli Naraghi et al.
Syndecans are a family of four-member transmembrane heparan sulfate proteoglycans that bind to various extracellular biomolecules, such as Wnt ligands, via their heparan sulfate chains, thereby controlling a variety of cellular processes. W...
Anti-cancer effect of Loranthus micranthus via downregulation of inflammation, Tryptophan catabolism and kynurenine synthesis [0.03%]
Loranthus micranthus的抗肿瘤效果通过下调炎症、色氨酸分解代谢和犬尿酸合成实现
Azubuike P Ebokaiwe,Lingyu Li,Ting Peng et al.
Azubuike P Ebokaiwe et al.
New therapeutic approaches are essential in the fight against breast cancer, which remains one of the top causes of mortality globally. Innovative and efficient methods of treating and preventing cancer has become expedient since its incide...
Qiao Ling,Manqi Cao,Hua-An Zhang et al.
Qiao Ling et al.
The KCTD gene family is conserved across species, yet the knowledge of its function is limited. Recently, increasing studies focused on KCTD5 emerged. The functions of KCTD5 and its associations with various diseases were revealed. However,...
Antigen-presenting cells orchestrate mixed inflammatory endotypes in atopic dermatitis [0.03%]
过敏性皮炎中的抗原呈递细胞协调混合型炎症表型
Shan Wang,Jiahao Huang,Fangping He et al.
Shan Wang et al.
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a complex pathogenesis involving aberrant activation of multiple immune responses. In recent years, targeted biologics have demonstrated significant efficacy in ...
Lin Cheng,Ge Wu,Wei Yao et al.
Lin Cheng et al.
The function of silencing information regulator 1 (SIRT1) in promoting or inhibiting apoptosis remains a subject of debate. Here, we aim to evaluate the roles of nuclear-localized SIRT1 in STS/DOX-induced apoptosis. Silencing nuclear-locali...
Substrate Stiffness Modulates Osteogenic Differentiation of BMMSCs via the Hedgehog Signaling Pathway [0.03%]
基质刚度通过Hh信号通路调控BMMSCs向成骨细胞分化
Chengyang Sun,Mengying Jin,Ying Lian et al.
Chengyang Sun et al.
Substrate stiffness is a critical biophysical cue regulating mesenchymal stem cell (MSC) fate, yet the underlying mechanisms remain incompletely understood. Here, we investigated how substrate stiffness modulates the osteogenic differentiat...
Inhibition of ERO1A by TCF21 curbs aerobic glycolysis and enhances immune recognition in lung adenocarcinoma [0.03%]
TCF21通过抑制ERO1A遏制肺癌腺癌的糖酵解和增强免疫识别作用
Xiaoyu Zheng,Bin Jiang,Yingchun Zhang et al.
Xiaoyu Zheng et al.
Background: Among the many malignancies, lung adenocarcinoma (LUAD) is a top global health and life risk. The focus of this research is to explore how the TCF21/ERO1A pathway influences the immune escape mechanisms trigge...