Coelonin, an active component extract from Bletilla striata (Thunb.) Reichb.f., alleviates lipopolysaccharide-induced acute lung injury by increasing the expression of non-coding RNA Gm27505 and inhibiting the M1 polarization of macrophages caused by inflammatory responses [0.03%]
从虾脊兰中提取的活性成分石蒜宁通过增加非编码RNA Gm27505表达和抑制炎症反应诱导的巨噬细胞M1极化治疗脂多糖引起的急性肺损伤
Run-Ze Qin,Su-Yu Peng,Zi-Xin Huang et al.
Run-Ze Qin et al.
Coelonin is a dihydrophenanthrene compound derived from the traditional Chinese medicine Bletilla striata (Thunb.) Reichb.f., which exhibits significant anti-inflammatory activity and effectively inhibits lipopolysaccharide (LPS)-induced in...
Bielong Ruangan decoction inhibits tumor growth and improves immune response in a hepatocellular carcinoma mouse model through gut microbiota [0.03%]
补 long 室方通过调节肠道菌群抑制肝癌细胞生长及改善免疫应答
Ruoyu Wang,Dan Tang,Lingyu Wu et al.
Ruoyu Wang et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer fatality worldwide. It is closely linked to the gut-liver axis, which plays a crucial role in nutrient metabolism, immune responses, and the biotransformation of bacterial metaboli...
The DNA damage response in myogenic C2C7 cells depends on the characteristics of ionizing particles [0.03%]
辐照特性影响肌源性C2C7细胞的DNA损伤修复响应路径
Haser H Sutcu,Arthur Thomas-Joyeux,Mikaël Cardot-Martin et al.
Haser H Sutcu et al.
DNA integrity and stability are vital for proper cellular activity. Nevertheless, to treat cancer patients, DNA is the main target for inducing tumoral cell death. Nowadays, cancer treatment is improving by the development of new technologi...
Pyruvate kinase M2 (PKM2) regulates rheumatoid arthritis by mediating glycolysis reprogramming through the Akt/mTOR pathway [0.03%]
丙酮酸激酶M2(PKM2)通过Akt/mTOR信号通路调节糖酵解再编程以调控类风湿关节炎发生发展
Hai-Yang Liao,Guo-Hua Zhang,Jian-Xiong Zheng et al.
Hai-Yang Liao et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Fibroblast-like synovial cells (FLSs) are the main effector cells in the synovial microenvironmen...
ATP1B4 as a Candidate Upstream Regulator of Muscle Atrophy in Diabetic Sarcopenia via PI3K/AKT/mTOR-Mediated Autophagy [0.03%]
ATP1B4通过PI3K/AKT/mTOR介导的自噬在糖尿病肌少症中作为肌肉萎缩候选上游调节因子
Tingting Duan,Shumin Jia,Dan Zhou et al.
Tingting Duan et al.
Objective: This study aimed to elucidate the regulatory role of the muscle-specific gene ATP1B4 in skeletal muscle metabolism and mitophagy in diabetic sarcopenia (DS) rats. ...
β-Tricalcium phosphate nanoparticles induce macrophage polarization to M1-type through mitochondrial oxidative stress activation [0.03%]
β-三钙磷酸盐纳米颗粒通过线粒体氧化应激激活将巨噬细胞极化为M1型
Yunbing Chen,Xinping Li,Hongyi Yang et al.
Yunbing Chen et al.
β-Tricalcium phosphate (β-TCP), frequently employed for bone tissue regeneration, can induce inflammation during the initial phases of implantation within the organism. However, mechanisms by which β-TCP nanoparticles (NPs) cause this in...
Chromobox protein homolog 7 (CBX7) deficiency inhibits osteoblast ferroptosis by activating the Nrf2 function in type 2 diabetic osteoporosis [0.03%]
染色体排列盒蛋白同源物7（CBX7）缺陷通过激活Nrf2功能抑制2型糖尿病骨质疏松性成骨细胞铁死亡
Yongwei Du,Fangtian Xu,Shengwang Miao et al.
Yongwei Du et al.
Background: Ferroptosis occurs in osteoblasts in a diabetic environment, which impairs osteoblast number and function, promotes osteoblast death, destroys bone homeostasis, and eventually contributes to type 2 diabetic os...
Characterizing the role of extracellular domain in GLP-1R biased agonism [0.03%]
GLP-1受体偏置激动剂的作用机制及外显域的作用研究进展
Linshan Xie,Rong Xu,Huining Liu et al.
Linshan Xie et al.
The biased agonism of glucagon-like peptide-1 receptor (GLP-1R) plays a key role in the efficacy and side effects of drugs used to treat type II diabetes mellitus and obesity. Despite its therapeutic potential, the mechanisms underlying GLP...
Escin alleviates DNCB-induced atopic dermatitis-like symptoms by promoting autophagy activation and tight junction barrier restoration [0.03%]
escin通过促进自噬激活和紧密连接屏障修复来缓解DNCB诱导的特应性皮炎样症状
Zhenxing Liu,Jingye Zhao,Lei Zhang et al.
Zhenxing Liu et al.
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by impaired skin barrier function and immune dysregulation. Autophagy, a lysosome-dependent degradation pathway essential for removing unnecessary components, plays...
Hibernating brown bear serum modulates the balance of TGF-β and BMP pathways in human muscle cells [0.03%]
休眠棕熊血清调节TGF-β和BMP信号通路在人体肌细胞中的平衡
Chloé Richard,Charlène Pourpe,Guillaume Fourneaux et al.
Chloé Richard et al.
Muscle atrophy is observed in several pathophysiological situations, including physical inactivity, leading to negative health consequences, without any effective treatment currently available. Conversely, brown bears resist muscle atrophy ...