CTCF β-hydroxybutyrylation catalyzed by NAT10 regulates MHC-II gene expression [0.03%]
NAT10催化CTCF羟基丁酰化调控MHC-II基因表达
Rui Zhou,Shirui Li,Siyi Jiang et al.
Rui Zhou et al.
The CCCTC-binding factor (CTCF) protein and its posttranslational modifications are critical for gene expression and genome organization, yet the biological significance of CTCF β-hydroxybutyrylation (Kbhb) has remained unclear. In this st...
Estradiol facilitates urate excretion by reducing GLUT9 expression via ERβ/TMEM106B/PI3K/AKT1 pathway in renal tubular epithelial cells [0.03%]
雌二醇通过ERβ/TMEM106B/PI3K/AKT1信号轴下调肾小管上皮细胞GLUT9表达促进尿酸排泄
Haijun Liu,Zizi Xiao,Shulin Yue et al.
Haijun Liu et al.
Aim: Gout is the chronic manifestation of hyperuricemia triggered by urate precipitation in joints and tendons, affecting 41 million adults worldwide. Promoting excretion of urate is the most important strategy for treati...
EFNA3-mediated autophagy suppression drives breast cancer proliferation, EMT and metastasis via PI3K/AKT/mTOR axis [0.03%]
通过PI3K/AKT/mTOR轴抑制自噬的EFNA3驱动乳腺癌增殖、EMT和转移
Luoqiang Lin,Yupeng Yang,Zhenlong Zhang et al.
Luoqiang Lin et al.
Background: Breast cancer is a major contributor to cancer mortality in women, and progression, metastasis, and therapy resistance remain key clinical challenges. Ephrin-A3 (EFNA3) has been implicated in various cancers, ...
Investigating the effects of post-exercise serum treatments on APP processing in iPSC-derived neurons and astrocytes [0.03%]
探讨运动后血清对诱导多能干细胞来源的神经元和星形胶质细胞APP加工的影响
Richard J Elsworthy,Felicity Spencer,Sophie Allen et al.
Richard J Elsworthy et al.
The number of people living with Alzheimer's disease (AD) is increasing worldwide as populations age. A hallmark of AD is the accumulation of amyloid-β (Aβ) in the brain, and pathways regulating amyloid-β precursor protein (AβPP) proces...
Felix N Tajanko,Cynthia R Muller,Carlos Munoz et al.
Felix N Tajanko et al.
This study explores the effects of exogenous estradiol on inflammatory, metabolic, and organ-function responses to lipopolysaccharide (LPS)-induced endotoxemia using a murine model. Male, female, and estradiol-supplemented female mice were ...
PROTAC-Mediated Degradation of Class I HDACs by JPS016 Alleviates Septic Cardiomyopathy via Mitophagy-Driven Exopher Formation and Mitochondrial Quality Control [0.03%]
通过线粒体自噬驱动的外网格蛋白复合物形成和线粒体质量控制，由JPS016介导的PROTAC I类HDAC降解可缓解脓毒性心肌病
Zhaokai Li,Weijian Zhang,Guoqiang Zhang
Zhaokai Li
Septic cardiomyopathy (SCM) is a severe complication of sepsis with limited targeted treatment options, largely due to mitochondrial dysfunction in cardiomyocytes. Exophers, extracellular vesicles responsible for removing damaged mitochondr...
Luteolin prevents hyperoxaluria-induced renal injury by inhibiting crystal deposition and renal inflammation [0.03%]
黄酮类化合物山柰素通过抑制结晶沉积和肾炎预防高草酸盐尿引起的肾损伤
Zhenghui Jin,Shiqing Zhu,Chengwei Wang et al.
Zhenghui Jin et al.
Objective: To evaluate the protective effects of Luteolin (LUT) against hyperoxaluria-induced renal injury and calcium oxalate (CaOx) crystal deposition, and to explore the underlying molecular mechanisms. ...
Research and application of direct current in medicine: From cellular and molecular mechanisms to clinical application in ophthalmology [0.03%]
直流电在医学中的研究与应用：从细胞和分子机制到眼科临床应用
Chunyang Cai,Yuntian Wan,Qingquan Wei et al.
Chunyang Cai et al.
Direct current (DC) is a direction-constant current, and the research on its biological mechanism is expanding from traditional physical therapy to the field of precision medicine. This comprehensive review systematically summarizes the phy...
MFN2 interacts with phosphorylated AMPK to mediate mitophagy in MCF-7 cells [0.03%]
MFN2通过与磷酸化AMPK相互作用介导MCF-7细胞的线粒体自噬
Shixian Zhai,Zihong Huang,Chunchun An et al.
Shixian Zhai et al.
Mitofusin 2 (MFN2) has been reported to play an important role in mitophagy, but how MFN2 mediates mitophagy remains incompletely understood. Here, we establish that MFN2 upregulation is a key driver of mitophagy in MCF-7 cells. MFN2 overex...
CircTHBS1 aggravates peritoneal fibrosis by sponging miR-18a-5p and interacting with CTGF [0.03%]
Circular RNA Circthbs1通过海绵吸附miR-18a-5p及与CTGF互作加重腹膜纤维化
Yanhong Guo,Silu Zhao,Xuewen Zhang et al.
Yanhong Guo et al.
Background: Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis (PD). Previous studies have demonstrated that circular RNAs (circRNAs) play an important role in organ fibrosis. However, whether ...