Adipose tissue macrophages-derived exosomal MiR-500a-5p under high glucose promotes adipocytes inflammation by suppressing Nrf2 expression [0.03%]
高糖环境下来源于脂肪组织巨噬细胞的外泌体MiR-500a-5p通过抑制Nrf2表达促进脂肪细胞炎症反应
Yong-Zhen Li,Yuan Tian,Chen Yang et al.
Yong-Zhen Li et al.
Background: Type 2 diabetes (T2DM) is a chronic metabolic disorder characterized by insulin resistance and chronic inflammation. Adipose tissue macrophages (ATMs), central players in mediating pro-inflammatory responses w...
Meredith Hill,Sarah Stapleton,Phuong Thao Nguyen et al.
Meredith Hill et al.
MicroRNAs (miRNA,miRs) are small noncoding RNAs that are ubiquitously expressed in all mammalian cells. Their primary function is the regulation of nascent RNA transcripts by direct binding to regions on the target. There is now exciting da...
Unveiling a novel signalling pathway involving NRF2 and PGAM5 in regulating the mitochondrial unfolded protein response in stressed cardiomyocytes [0.03%]
揭示NRF2和PGAM5在应激心肌细胞中调节线粒体未折叠蛋白反应的新信号通路
Rahme Nese Safakli,Stephen P Gray,Nadia Bernardi et al.
Rahme Nese Safakli et al.
The mitochondrial unfolded protein response (UPRmt) is a conserved signalling pathway that initiates a specific transcriptional programme to maintain mitochondrial and cellular homeostasis under stress. Previous studies have demonstrated th...
Immune-epithelial cell interactions in lung development, homeostasis and disease [0.03%]
肺发育、稳态及疾病中的免疫上皮细胞相互作用
Masahiro Yoshida,Romina Arzili,Marko Z Nikolić
Masahiro Yoshida
The importance of the crosstalk between lung epithelial and immune cells, which emerges from early development and lasts throughout life, is corroborated by a growing body of scientific evidence. This communication not only has a role in dr...
Regulatory role of AMPK/Nrf2 signaling pathway in sevoflurane-enhanced intestinal protection against ischemia-reperfusion injury [0.03%]
AMPK/Nrf2信号通路在异氟烷增强肠道缺血再灌注损伤保护中的作用机制研究
Xiaohua Zeng,Shan Jiang,Yinghui Wu et al.
Xiaohua Zeng et al.
Intestinal ischemia-reperfusion (I/R) injury is common in clinical settings and is associated with high mortality. Sevoflurane, a widely used anesthetic, has long recognized for its protective effects against intestinal I/R injury, though t...
Transcriptomic and in silico analysis of BLACE (B-cell acute lymphoblastic leukemia expressed), a new non-coding RNA, as a diagnostic biomarker in B-cell ALL [0.03%]
BLACE（B细胞急性淋巴细胞白血病表达）的转录组和计算机分析：作为B细胞ALL诊断生物标志物的新非编码RNA
Saadiya Zia,Nazia Rehman,Saima Ejaz et al.
Saadiya Zia et al.
ALL (acute lymphoblastic leukemia) is a type of hematological malignancy that involves developmental and differentiation arrest at the lymphoblast stage. BLACE, a gene specifically expressed in B-cell acute lymphoblastic leukemia shows litt...
Use of Myriocin as co-adjuvant in glaucoma surgery: An in vitro study [0.03%]
我的小键盘出现问题了呢，这道题目的意思是让把关于原发性进行性肾小球疾病的里西替尼和巴瑞克替尼的对照研究的英文标题翻译成中文。不过这里的“Use of Myriocin as co-adjuvant in glaucoma surgery: An in vitro study”可以翻译为：作为手术辅助用药的Myriocin在青光眼治疗中的应用：一项体外实验
Linda Montavoci,Dario Romano,Leonardo Colombo et al.
Linda Montavoci et al.
Mitomycin C as well as other antiproliferative drugs are off-label agents widely used to prevent the failure of glaucoma surgery due to activation of Tenon's fibroblasts and the ensuing excessive subconjunctival scarring. Though efficacious...
MLN4924 Suppresses head and neck squamous cell carcinoma progression by inactivating the mTOR signaling pathway via the NEDD8/CUL4/TSC2 axis [0.03%]
MLN4924通过NEDD8/CUL4/TSC2轴抑制mTOR信号通路来抑制头颈鳞状细胞癌的发展进展
Youfang Jiang,Fei Le,Shuangling Huang et al.
Youfang Jiang et al.
Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with a five-year survival rate below 50 %. Standard treatments for HNSCC include surgery, radiotherapy, chemotherapy, and targeted therapies, but they still have signific...
Antitumor effect of bromo-naphthoquinone associated with tannic acid in triple negative breast cancer cells [0.03%]
联苯萘醌联合单宁酸在三阴性乳腺癌细胞中的抗肿瘤作用研究
Emanuelle Pangoni de Carvalho,Adriano de Souza Pessoa,Flávia Godoy Iano et al.
Emanuelle Pangoni de Carvalho et al.
Triple-negative breast cancer (TNBC) is an aggressive type of tumor that tends to recur in women. It is characterized by the absence of hormonal receptors, making it challenging to diagnosis and treatment. In this study, we investigated the...
Haruka Nishimura,Yun Li
Haruka Nishimura
The hippocampus is a crucial structure of the brain, recognised for its roles in the formation of memory, and our ability to navigate the world. Despite its importance, clear understanding of how the human hippocampus develops and its contr...