Association of long non-coding RNA in Lipid metabolism: Implications in Leukemia [0.03%]
脂代谢相关长链非编码RNA的特性及其在白血病中的作用机制研究
Anjani Alluri,Pallavi Saxena,Amit Mishra et al.
Anjani Alluri et al.
Cancer has high mortality rate and occupies second position among major diseases. Despite extensive research and therapies, in every nook and corner of the world, death rate is increasing exponentially. Hallmarks of cancer are benchmarks of...
Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system [0.03%]
造血干细胞培养上清通过调控热休克蛋白90和26S蛋白酶体系统诱导结直肠癌干细胞的凋亡
Sumit Mallick,Vanya Kadla Narayana,Akhila Balakrishna Rai et al.
Sumit Mallick et al.
Cancer stem cells (CSCs) hold a significant role in cancer metastasis, high mortality and severity responsible for therapy resistance and tumour recurrence. The 26S proteasome system plays a major role in protein degradation in normal cells...
Multi-channel smFRET study reveals a compact conformation of EF-G on the ribosome [0.03%]
多通道smFRET研究揭示了EF-G在核糖体上的紧缩构象
Jordan L Johnson,Jacob H Steele,Ran Lin et al.
Jordan L Johnson et al.
While elongation factor G (EF-G) is crucial for ribosome translocation, the role of its GTP hydrolysis remains ambiguous. EF-G's indispensability is further exemplified by the phosphorylation of human eukaryotic elongation factor 2 (eEF2) a...
Gabriella L Robertson,Caroline Bodnya,Vivian Gama
Gabriella L Robertson
The human brain is unique in its cellular diversity, intricate cytoarchitecture, function,and complex metabolic and bioenergetic demands, for which mitochondria and.peroxisomes are essential. Beyond providing energy in the form of ATP, mito...
Selective cerebral hypothermia alleviates focal cerebral ischemia/reperfusion injury via enhancing SUMO2/3 modification of Drp1 in rats [0.03%]
选择性脑低温通过增强Drp1的SUMO2/3修饰减轻大鼠局灶性脑缺血/再灌注损伤
Yang Yuan,Li Fu,Wenji Liu et al.
Yang Yuan et al.
Background: Selective Cerebral Hypothermia (SCH) has been demonstrated to potentiate SUMO2/3 modification, a native cellular safeguard against Cerebral Ischemia/Reperfusion Injury (CIRI). Dynamin-Related Protein 1 (Drp1),...
Regulatory Role of TEX10 Gene in Proliferation Differentiation and Apoptosis of Bovine Myoblasts [0.03%]
TEX10基因在牛肌样细胞增殖分化及凋亡中的调控作用
Yongpan Wang,Zijing Zhang,Yuqiao Zhang et al.
Yongpan Wang et al.
Skeletal muscle is a crucial tissue involved in body movement and energy metabolism, and its growth and development directly influence the economic value of livestock. This study investigates the effects of the TEX10 gene on the proliferati...
Identify key genes and biological processes participated in obesity- related cancer based on studying 12 cancers [0.03%]
基于研究12种癌症识别参与肥胖相关癌症的关键基因和生物过程
Lijuan Zhu,Cuicui Zhao
Lijuan Zhu
Obesity significantly increases the risk of various diseases, particularly cancers, which present a serious threat to public health. Therefore, identifying cancers related to obesity and exploring their pathological pathways and key genes a...
SIRT2 inhibition attenuates myofibroblast transition through autophagy-mediated ciliogenesis in renal epithelial cells [0.03%]
SIRT2抑制通过肾上皮细胞中的自噬介导的纤毛发生来减弱肌成纤维细胞转分化过程
Juyoung Son,Jaejung Park,Joo-Won Jeong et al.
Juyoung Son et al.
Myofibroblast transition plays a crucial role in both fibrotic diseases and wound healing. Although SIRT2 regulates fibrosis, its mechanisms of action remain poorly understood. This study aimed to investigate the effects of SIRT2 inhibition...
Enhancement of wound healing in diabetic mice by topical use of a peptide-ionic liquid conjugate [0.03%]
肽-离子液体偶联物的外用促进糖尿病小鼠伤口愈合
Ana Gomes,Ermelindo C Leal,Jessica Da Silva et al.
Ana Gomes et al.
Diabetic foot ulcers (DFU) are one of the most devastating complications of diabetes, with high impact on patient's quality of life. In worst scenarios, DFU can lead to severe amputation or even death. DFUs are an easy target for microbial ...
Expression analysis of molecular chaperones associated with disaggregation complex in rotenone-induced Parkinsonian rat model [0.03%]
罗登胺诱导帕金森病大鼠模型中与离聚复合物相关分子伴郎热休克蛋白的表达分析
Tanu,Minal Chaturvedi,Siraj Fatima et al.
Tanu et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the aberrant aggregation and phosphorylation (ser129) of α-synuclein (α-syn, a presynaptic protein) which leads to the formation of pathogenic Lewy bodi...