Critical role of argininosuccinate lyase in TAp73-mediated proliferating tumor cells [0.03%]
精氨琥珀酸裂解酶在TAp73介导的增殖性肿瘤细胞中的关键作用
Jie Zhang,Min Zhao,Haolan Zhang et al.
Jie Zhang et al.
The dysregulation of the urea cycle resulting in an excessive buildup of ammonia is identified as a pivotal mechanism driving tumor progression. In particular, argininosuccinate lyase (ASL) is crucial for cancer cell proliferation, cleaves ...
Mycobacterium tuberculosis curli pili reduces oxygen consumption rate of THP-1 macrophages during early infection [0.03%]
结核分枝杆菌curli菌毛通过降低巨噬细胞糖酵解速率抑制宿主抗胞内微生物免疫反应
Shinese Ashokcoomar,Tarien J Naidoo,Bridgette M Cumming et al.
Shinese Ashokcoomar et al.
The development of improved anti-tuberculosis (TB) strategies to address drug-resistance and ineffectual TB treatment regimens should focus on interrupting the initial host-pathogen interaction. This study aimed to elucidate the effect of s...
Deciphering the molecular heterogeneity of soft tissue sarcoma by integrating multiomics and single cell sequence [0.03%]
通过整合多组学和单细胞测序解码软组织肉瘤的分子异质性
Haixiang Zhang,Peng Luo,Hao Jiang et al.
Haixiang Zhang et al.
Background: Soft tissue sarcoma is a highly malignant tumor with extensive heterogeneity across multiple omics. However, a comprehensive multi-omics subtyping system has not yet been established. ...
Silencing HMGB1 secretion inhibited EV71-induced blood-brain barrier dysfunction and neural inflammation by depressing astrocyte activation via sHh signal blockage [0.03%]
沉默HMGB1分泌通过抑制sHh信号诱导的星形胶质细胞活化从而抑制EV71引起的血脑屏障功能障碍和神经炎症反应
Yufeng Zhang,Yanfang Liu,Han Wan et al.
Yufeng Zhang et al.
It is unclear whether high mobility group protein B1 (HMGB1) is associated with the malignant characterization of hand, foot, and mouth disease (HFMD), and whether it plays a key regulatory role in the process of enterovirus 71 (EV71)-induc...
Restoration of A2M reduces drug resistance and malignancy in paclitaxel-resistant lung cancer cells [0.03%]
A2M的恢复可减少紫杉醇耐药性肺癌细胞的药物抵抗和恶性肿瘤形成能力
Xiaona Fan,Hongsheng Xue,Ziwei Liu et al.
Xiaona Fan et al.
The development of acquired paclitaxel resistance poses a significant challenge in managing lung cancer clinically. Understanding the mechanism and developing effective strategies to counter paclitaxel resistance are highly desired. To expl...
Single-Cell Transcriptomics and Metabolomics Reveal the Potential Role of ASRGL1 in Metabolic Reprogramming and Invasion of Nasopharyngeal Carcinoma Cells [0.03%]
单细胞转录组和代谢组揭示ASRGL1在鼻咽癌细胞代谢重塑及侵袭中的潜在作用
YingYing Pei,Chunlin Li,Bin Zhang et al.
YingYing Pei et al.
Nasopharyngeal carcinoma (NPC) is an aggressive and highly metastatic malignancy, presenting significant challenges for early diagnosis and treatment. Asparaginase-like protein 1 (ASRGL1) is an important enzyme involved in amino acid metabo...
Acalabrutinib alleviates metabolic dysfunction-associated steatotic liver disease by regulating bile acid metabolism [0.03%]
通过调节胆汁酸代谢改善与代谢紊乱相关的肝脂肪变性疾病的活性溴结构类药物疗法研究进展
Yanbo Wang,Shiwei Chen,Bingjue Ye et al.
Yanbo Wang et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global epidemic of chronic liver disease currently lacking effective treatment. Evaluating the therapeutic effects of existing drugs on MASLD is a time and cost-effective...
Inhibition of M2 Macrophage-Mediated Mesenchymal Stem Cell Migration: Boldine Attenuates Elbow Heterotopic Ossification [0.03%]
boldine通过抑制M2型巨噬细胞介导的间充质干细胞迁移而缓解异位骨化
Fengteng Shen,Yansong Chen,Zhikun Xu et al.
Fengteng Shen et al.
Background: Heterotopic ossification (HO) is characterized by abnormal bone formation in soft tissues, often following trauma or surgery. Transforming growth factor-beta (TGF-β) signaling and M2 macrophage polarization p...
Morin inhibits the progression of 5-fluorouracil-resistant colorectal cancer by suppressing autophagy [0.03%]
MOR能通过抑制自噬抑制5-氟尿嘧啶耐药结直肠癌的进展
Rui Li,Fengxia Wang,Lu Huang et al.
Rui Li et al.
Background: Resistance to 5-fluorouracil (5-FU) poses a significant challenge in colorectal cancer (CRC) treatment. Morin is a flavonoid with anti-tumor properties. However, its role in overcoming acquired 5-FU resistance...
CAPRIN1/TYMS/MTHFD2 axis promotes EMT process in nasopharyngeal carcinoma development [0.03%]
鼻咽癌发生发展中CAPRIN1/TYMS/MTHFD2轴促进上皮间质转化过程
Kunrong Wang,Hanbing Yu,Shuang Guo et al.
Kunrong Wang et al.
Background: Nasopharyngeal carcinoma (NPC) is a type of malignant tumor occurring in the nasopharynx. It frequently leads to treatment failure after metastasis, often resulting from epithelial-mesenchymal transition (EMT)...