METTL5-mediated m6A modification of SLC7A11 promotes cervical cancer by inhibiting ferroptosis [0.03%]
METTL5介导的SLC7A11m6A修饰通过抑制铁死亡促进宫颈癌发生发展
Yujin Dong,Wei Chang,Bei Lu et al.
Yujin Dong et al.
Ferroptosis could suppress the viability of cervical cancer cells and trigger their death, thereby offering a unique perspective for exploring novel therapeutic approach for cervical cancer. Here, this study tried to explore the role of N6-...
Maternal high-fat diet-induced obesity in offspring: Unraveling adipose tissue dysfunction mediated by increased heat shock proteins [0.03%]
母体高脂饮食引起的后代肥胖：通过增加热休克蛋白介导的脂肪组织功能障碍来揭示
Henry A Paz,Lasya Buddha,Tianfu Lam et al.
Henry A Paz et al.
Maternal weight and diet before and during pregnancy have a substantial impact on offspring metabolic health, though sex-specific differences in metabolic and adipose tissue adaptations to maternal overnutrition remain insufficiently unders...
Cofilin is a key regulator of oxidative stress-induced intercellular tunneling nanotubes formation [0.03%]
科菲林是氧化应激诱导的细胞间隧道纳米管形成的关键调节因子
Hongce Chen,Zhirui Wu,Lingyu Wang et al.
Hongce Chen et al.
Tunneling nanotubes (TNTs) are open membranous channels between connected cells, TNTs-mediated substance transfer between tumor cells plays an important role in drug resistance, metastasis and recurrence of tumors. This study aims to explor...
Cannabigerol - A potent regulator of insulin sensitivity in rat's skeletal muscle via targeting the sphingolipid metabolism and PI3K/Akt/mTOR pathway? [0.03%]
大麻萜酚通过靶向类脂代谢及PI3K/Akt/mTOR信号通路调节胰岛素敏感性吗？
Patrycja Bielawiec,Lara Swierkot,Karolina Konstantynowicz-Nowicka et al.
Patrycja Bielawiec et al.
Despite the great advances in medicine, there is a compelling need to develop alternative strategies to effectively treat obesity with the use of plant-origin therapeutics. Cannabigerol (CBG) appears to be a novel promising compound for man...
Medium-dose irradiation impairs long-term hematopoietic stem cell functionality and hematopoietic resilience to cytotoxic stress [0.03%]
中剂量照射损害长期血干细胞功能及造血系统抵抗细胞毒性损伤的潜能
Qinyu Zhang,Anna Rydström,Isabel Hidalgo et al.
Qinyu Zhang et al.
Irradiation and 5-fluorouracil (5-FU) are widely utilized tools in hematopoietic research to generate myeloablation and assess blood recovery dynamics. A comprehensive understanding of their effects on the hematopoietic system is essential ...
Bifidobacterium Apoptosis Induction by Measuring Bax and Caspases on SW948 Human Colon Cancer Cell Line [0.03%]
定量测定枯草热诱导蛋白 apoptosis-相关基因表达及形态学变化
Maryam Soraya,Elham Moazamian,Seyedeh Azra Shamsdin et al.
Maryam Soraya et al.
Backgrand: Nowadays, probiotic bacteria have been considered as a factor in the prevention and treatment of cancer, especially by induction of apoptosis. The aim of study, the isolation and identification of Bifidobacteri...
p38 MAPK-mediated upregulation of claudin-3 and claudin-4 by gemcitabine contributes to chemoresistance in ovarian cancer [0.03%]
吉西他滨通过P38 MAPK介导的claudin-3和claudin-4上调诱导卵巢癌耐药性
Jiaxin Zhao,Jianli Ke,Xiaochao Cao et al.
Jiaxin Zhao et al.
Chemotherapy is a primary therapeutic option in cancer treatment, but often associated with unwanted side effects and drug resistance. Claudin-3 (CLDN3) and claudin-4 (CLDN4) are essential components of tight junctions, frequently overexpre...
Serine phosphorylation of protein arginine methyltransferase Hmt1 is critical for controlling its protein levels [0.03%]
丝氨酸磷酸化对调控组蛋白甲基转移酶Hmt1的蛋白质水平至关重要
Sai Wu,Vincent Rossi,Christopher A Jackson et al.
Sai Wu et al.
In eukaryotes, protein arginine methylation is a prevalent post-translational modification found in a multitude of proteins responsible for key biological processes, ranging from transcription to signaling. One model suggests that phosphory...
Clostridium butyricum protects the ileal barrier in mice by regulating the farnesoid X receptor signaling pathway [0.03%]
芽孢杆菌通过调节法尼醇X受体信号通路保护小鼠回肠屏障功能
Hanfei Wang,Li Hou,Xintong Chen et al.
Hanfei Wang et al.
Background: The intestinal barrier has an important role in maintaining homeostasis. The aim of this study was to determine the protective effect of Clostridium butyricum (CBM) on small intestinal barrier damage in mice a...
ARHGAP11A is a potential prognostic biomarker and therapeutic target for pancreatic adenocarcinoma [0.03%]
ARHGAP11A是胰腺导管腺癌的潜在预后生物标志物和治疗靶点
Qiu-Ai Shu,Xin-di Huang,Jian Wu et al.
Qiu-Ai Shu et al.
The prognosis of pancreatic adenocarcinoma remains dismal up to now, partly owing to a lack of clinically feasible therapeutic targets. ARHGAP11A, a member of Rho GTPase-activating proteins family, has been reported as a prognostic biomarke...