Ryanodine receptor Ca2+ release channel post-translational modification: Central player in cardiac and skeletal muscle disease [0.03%]
ryanodine受体钙释放通道的翻译后修饰：心脏和骨骼肌疾病的重要角色
Amanda Denniss,Angela F Dulhunty,Nicole A Beard
Amanda Denniss
Calcium release from internal stores is a quintessential event in excitation-contraction coupling in cardiac and skeletal muscle. The ryanodine receptor Ca2+ release channel is embedded in the internal sarcoplasmic reticulum Ca2+ store, whi...
Modelling the dorsal root ganglia using human pluripotent stem cells: A platform to study peripheral neuropathies [0.03%]
人多能干细胞 dorsal root ganglia 的体外模型：周围神经病变的研究平台
Serena Viventi,Mirella Dottori
Serena Viventi
Sensory neurons of the dorsal root ganglia (DRG) are the primary responders to stimuli inducing feelings of touch, pain, temperature, vibration, pressure and muscle tension. They consist of multiple subpopulations based on their morphology,...
NDRG1 disruption alleviates cisplatin/sodium glycididazole-induced DNA damage response and apoptosis in ERCC1-defective lung cancer cells [0.03%]
ERCC1缺陷的肺癌细胞中NDRG1失活通过减轻顺铂/甘氨双苷唑诱导的DNA损伤反应和凋亡来缓解化疗毒性作用
Lang He,Kang Liu,Xiaoshan Wang et al.
Lang He et al.
Background: Resistance to platinum-based chemotherapy becomes a major obstacle in lung cancer treatment. Compensatory activation of nucleotide excision repair (NER) pathway is the major mechanism accounting for cisplatin-...
Nicotine induced autophagy of Leydig cells rather than apoptosis is the major reason of the decrease of serum testosterone [0.03%]
尼古丁诱导的曲扎细胞自噬而非凋亡是导致血清睾酮下降的主要原因
Xianglong Zhao,Wangjie Xu,Jiajie Wu et al.
Xianglong Zhao et al.
A new report has shown that nicotine exposure can decrease serum testosterone by apoptosis in Leydig cells; however, in our previous studies, we have almost never observed apoptosis there. The purpose of this study is to ensure whether apop...
Time-course expression profile and diagnostic potential of a miRNA panel in exosomes and total serum in acute liver injury [0.03%]
急性肝损伤患者血浆外泌体和总血浆中microRNA表达谱及诊断价值研究
Tarek K Motawi,Mohamed R Mohamed,Nancy N Shahin et al.
Tarek K Motawi et al.
Circulating miRNAs have recently emerged as attractive candidates for biomarker discovery. However, they have a variant distribution in circulation, and the diagnostic significance of their compartmentalization is yet to be elucidated. This...
The inflammatory state of adipose tissue is not affected by the anti-inflammatory response of the A2a-adenosine system and miR-221/PTEN [0.03%]
脂肪组织炎性状态不受A2a腺苷系统和miR-221/PTEN抗炎反应的影响
J D Cortés-Garcia,M J Briones-Espinoza,M Vega-Cárdenas et al.
J D Cortés-Garcia et al.
Obesity is a chronic inflammatory state with cytokines, adipokines, and miRNAs. The A2a-adenosine system decreases activation and cytokine release in immune cells. MiR-221 is upregulated in carcinogenesis and inflammatory processes, where i...
MicroRNA-326 aggravates acute lung injury in septic shock by mediating the NF-κB signaling pathway [0.03%]
microRNA-326通过介导NF-κB信号途径加重脓毒性休克的急性肺损伤
Chun-Ting Wu,Yan Huang,Zhen-Ye Pei et al.
Chun-Ting Wu et al.
Our previous studies have demonstrated that the activation of the nuclear factor-kappa B (NF-κB) signaling pathway contributes to the development of lipopolysaccharide (LPS)-induced acute lung injury (ALI) as well as an inflammatory reacti...
Inhibitory effect of microRNA-154 targeting WHSC1 on cell proliferation of human skin squamous cell carcinoma through mediating the P53 signaling pathway [0.03%]
microRNA-154通过介导P53信号通路抑制WHSC1在人皮肤鳞状细胞癌细胞增殖中的作用
Hong-Quan Chen,Dong Gao
Hong-Quan Chen
Objective: Skin squamous cell carcinoma (SCC) is a common, morbid, and frequently lethal malignancy and ranks as the sixth most deadly cancer worldwide. Hence, this study aims to explore the effect of microRNA-154 (miR-15...
Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms [0.03%]
三环抗抑郁药通过不同的机制抑制海马体的α7*和α9α10型烟碱乙酰胆碱受体
Hugo R Arias,Elizabeth Vázquez-Gómez,Andy Hernández-Abrego et al.
Hugo R Arias et al.
The activity of tricyclic antidepressants (TCAs) at α7 and α9α10 nicotinic acetylcholine receptors (AChRs) as well as at hippocampal α7-containing (i.e., α7*) AChRs is determined by using Ca2+ influx and electrophysiological recordings...
Positive allosteric modulators of α7* or β2* nicotinic acetylcholine receptors trigger different kinase pathways in mitochondria [0.03%]
α7*或β2*烟碱乙酰胆碱受体的正变构调节剂触发线粒体中不同的激酶途径
Kateryna Uspenska,Olena Lykhmus,Hugo R Arias et al.
Kateryna Uspenska et al.
Mitochondrial nicotinic acetylcholine receptors (nAChRs) regulate the early stage of mitochondria-driven apoptosis, including cytochrome c release. Mitochondrial nAChR signaling is mainly mediated by intra-mitochondrial kinases, in an ion-i...