Benefit-risk of corticosteroids in acute gout patients: An updated meta-analysis and economic evaluation [0.03%]
急性痛风患者使用皮质类固醇的效益风险评估：一项更新的-meta-分析和经济评估研究
Xinliang Liu,Dehong Sun,Xiaosong Ma et al.
Xinliang Liu et al.
The efficacy, safety and health-economic outcomes were compared between corticosteroid and non-corticosteroid treatments in acute gout patients. All electronic literatures comparing the curative effects or full economic evaluations of corti...
Meta-Analysis
Steroids. 2017 Dec:128:89-94. DOI:10.1016/j.steroids.2017.09.002 2017
Twenty-four hour urinary cortisol excretion and the metabolic syndrome in prednisolone-treated renal transplant recipients [0.03%]
肾移植受者糖皮质激素治疗与二十四小时尿游离皮质醇水平及代谢综合征的关系
Laura V de Vries,Wilhelmina H A de Jong,Daan J Touw et al.
Laura V de Vries et al.
Chronic prednisolone treatment in renal transplant recipients (RTR) causes metabolic abnormalities, which cluster in the metabolic syndrome (MS). It also suppresses the hypothalamic-pituitaryadrenal (HPA)-axis. We investigated whether HPA-a...
The effects of chronic testosterone administration on body weight, food intake, and fat weight were age-dependent [0.03%]
慢性睾丸激素的摄入对体重、摄食量和脂肪重量的影响取决于年龄大小
Takeshi Iwasa,Toshiya Matsuzaki,Mayila Yiliyasi et al.
Takeshi Iwasa et al.
Previously, we showed that chronic testosterone administration increased body weight (BW) and food intake (FI), but did not alter fat weight, in young female rats. To examine our hypothesis that the effects of androgens on BW, FI and body c...
Synthesis and in vitro anticancer activity of 23(23')E-benzylidenespirostanols derived from steroid sapogenins [0.03%]
源自甾体皂苷元的23（23′）E-本扎烯斯皮罗斯坦醇的合成及体外抗肿瘤活性评价
Manuel A Ramos-Enríquez,Katherine Vargas-Romero,Lucie Rárová et al.
Manuel A Ramos-Enríquez et al.
Benzylidenespirostanols were prepared by two-step synthesis including BF3·Et2O-catalyzed aldol condensation of several acetylated steroid sapogenins with benzaldehyde followed by saponification. The obtained compounds showed moderate cytot...
Izabella Jastrzebska,Jacek W Morzycki
Izabella Jastrzebska
This article presents new transformations of solasodine - a representative steroid alkaloid sapogenin from the Solanum family. Oxidation of N,O-diacetylated solasodine with either NaNO2/BF3·Et2O or t-BuONO/BF3·Et2O resulted in partial deg...
Synthesis and evaluation of antitumor, anti-inflammatory and analgesic activity of novel deoxycholic acid derivatives bearing aryl- or hetarylsulfanyl moieties at the C-3 position [0.03%]
一类新型熊去氧胆酸衍生物的合成及其抗肿瘤、抗炎和镇痛活性评价
Irina I Popadyuk,Andrey V Markov,Ekaterina A Morozova et al.
Irina I Popadyuk et al.
Novel deoxycholic acid (DCA) derivatives were stereoselectively synthesised with -OH and -CH2SR moieties at the C-3 position, where R was a substituted aryl [2-aminophenyl (8) or 4-chlorophenyl (9)] or hetaryl [1-methylimidazolyl (5), 1,2,4...
New furostanol saponins with anti-inflammatory and cytotoxic activities from the rhizomes of Smilax davidiana [0.03%]
具抗炎和细胞毒活性的Smilax davidiana块根中的新乌苏烷皂苷
Meng Zhou,Liping Huang,Linyu Li et al.
Meng Zhou et al.
Seven new furostanol saponins have been isolated from the rhizomes of Smilax davidiana. Their structures were established by 2D NMR spectroscopic techniques (1H,1H-COSY, NOESY, HSQC and HMBC), mass spectrometry and comparison with the liter...
Corticosteroid inhibits chemokines production in systemic sclerosis patients [0.03%]
糖皮质激素抑制系统性硬化症患者的化学因子生成
Andréa Tavares Dantas,Anderson Rodrigues de Almeida,Maria Clara Pinheiro Duarte Sampaio et al.
Andréa Tavares Dantas et al.
In this study, we evaluated glucocorticoids (GC) effects on cytokine/chemokine levels in serum samples and peripheral blood mononuclear cell (PBMC) production from systemic sclerosis (SSc) patients. We evaluated cytokine and chemokine level...
Development of monoclonal antibodies against the human 3β-hydroxysteroid dehydrogenase/isomerase isozymes [0.03%]
人3β-羟基类固醇脱氢酶/异构酶同工酶单克隆抗体的研制
Celso E Gomez-Sanchez,Mark Lewis,Kazutaka Nanba et al.
Celso E Gomez-Sanchez et al.
The human 3β-hydroxysteroid dehydrogenase/isomerase (HSD3B) enzymes catalyze the conversion of 3β-hydroxy Δ5-6 steroids into 3-keto Δ4-5 steroids, which is required for the synthesis of the mature steroid hormones secreted by the adrena...
Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study [0.03%]
通过交叉易位合成新型芳基 brassinosteroid 素及初步生物活性研究
Petra Korinkova,Vaclav Bazgier,Jana Oklestkova et al.
Petra Korinkova et al.
A series of phenyl analogues of brassinosteroids was prepared via alkene cross-metathesis using commercially available styrenes and 24-nor-5α-chola-2,22-dien-6-one. All derivatives were successfully docked into the active site of BRI1 usin...