Glucocorticoid treatment facilitates development of a metabolic syndrome in ovariectomized Macaca Mulatta fed a high fat diet [0.03%]
糖皮质激素治疗促进卵巢切除的食蟹猴高脂饮食代谢综合征的发展
Linzhao Li,Guang Yang,Guangneng Liao et al.
Linzhao Li et al.
Metabolic syndrome (MetS) is characterized by a cluster of key features, which include abdominal obesity, insulin resistance, hypertension, and dyslipidemia. The aim of this study was to assess the impact of elevated glucocorticoid levels o...
Comparative investigation of binding interactions between three steroidal compounds and human serum albumin: Multispectroscopic and molecular modeling techniques [0.03%]
三种类固醇化合物与人血清白蛋白相互作用的比较研究：多光谱和分子建模技术
Shan Huang,Jiangning Xie,Jianguo Cui et al.
Shan Huang et al.
Steroidal compounds have attracted great attentions in biomedical and pharmacological areas. The investigation of structural influences during protein-compound interactions helps in understanding both the biological effects and the mechanis...
Steroidal pheromones and their potential target sites in the vomeronasal organ [0.03%]
类固醇信息素及其在犁鼻器中的潜在靶位点
Andrea Rodewald,Daniel Mills,Veronika M Gebhart et al.
Andrea Rodewald et al.
Steroids are important olfactory signals in most mammalian species. The vomeronasal organ has been suspected to be the primary target of pheromones. In rat vomeronasal sensory neurons express steroid binding proteins and nuclear receptors. ...
Expression of membrane progesterone receptors (mPRs) in rat peripheral glial cell membranes and their potential role in the modulation of cell migration and protein expression [0.03%]
大鼠外周神经胶质细胞膜上表达的孕酮受体及其在调节细胞迁移和蛋白表达方面的潜在作用
Luca F Castelnovo,Valerio Magnaghi,Peter Thomas
Luca F Castelnovo
The role played by progestogens in modulating Schwann cell pathophysiology is well established. Progestogens exert their effects in these cells through both classical genomic and non-genomic mechanisms, the latter mediated by the GABA-A rec...
The expression of select genes necessary for membrane-associated estrogen receptor signaling differ by sex in adult rat hippocampus [0.03%]
成年大鼠海马区与膜雌激素受体信号通路相关的一些基因的表达因性别而异
John Meitzen,Kyla A Britson,Krista Tuomela et al.
John Meitzen et al.
17β-estradiol can rapidly modulate neuron function via membrane estrogen receptors (ERs) in a sex-specific manner. For example, female rat hippocampal neurons express palmitoylated versions of ERα and ERβ that associate with the plasma m...
Changes in plasma aldosterone and electrolytes levels, kidney epithelial sodium channel (ENaC) and blood pressure in normotensive WKY and hypertensive SHR rats following gonadectomy and chronic testosterone treatment [0.03%]
去势及睾丸素慢性治疗对正常血压WKY大鼠和高血压SHR大鼠血浆醛固酮、电解质水平，肾脏上皮钠通道（ENaC）和血压的影响
Su Yi Loh,Nelli Giribabu,Naguib Salleh
Su Yi Loh
We hypothesized that testosterone-induced increase in blood pressure involve changes in aldosterone levels and expression of epithelial sodium channel (ENaC) in the kidneys. ...
Balbina J Plotkin,Monika I Konakieva
Balbina J Plotkin
Upon entering the human host, Staphylococcus aureus is exposed to endogenous steroid hormones. The interaction between S. aureus and dehydroepiandosterone (DHEA) results in an increased resistance to the host cationic defense peptide, β-1 ...
Ziram inhibits aromatase activity in human placenta and JEG-3 cell line [0.03%]
唑醇抑制人胎盘和JEG-3细胞系中的芳香化酶活性
Lanlan Chen,Xiaomin Chen,Xiaozhen Chen et al.
Lanlan Chen et al.
Placenta produces progesterone and estradiol for maintaining pregnancy. Two critical enzymes are responsible for their production: 3β-hydroxysteroid dehydrogenase 1 (HSD3B1) that catalyzes the formation of progesterone from pregnenolone an...
Purity and stability of the membrane-limited glucocorticoid receptor agonist dexamethasone-BSA [0.03%]
抗炎药物地塞米松免疫复合物的纯度及稳定性研究
Grant L Weiss,Jennifer R Rainville,Qi Zhao et al.
Grant L Weiss et al.
Cellular effects of glucocorticoids can be separated into classical transcriptional regulation via activation of the canonical nuclear glucocorticoid receptor and rapid actions mediated by activation of one or more putative membrane-associa...
Full spectroscopic characterization of two crystal pseudopolymorphic forms of the antiandrogen cortexolone 17α-propionate for topic application [0.03%]
用于局部应用的抗雄激素кортексолон 17α- propionate两种晶体伪多晶型形式的全光谱表征
Patrizia Ferraboschi,Maria Chiara Sala,Riccardo Stradi et al.
Patrizia Ferraboschi et al.
Cortexolone-17α-propionate (CP) is a topically active antiandrogen useful in the treatment of skin disorders. In the solid state, three anhydrous forms of this drug (CPI, CPII and CPIII) occur, together with one hydrated crystal (CPW). The...