Aldosterone-induced protein kinase signalling and the control of electrolyte balance [0.03%]
醛固酮诱导的蛋白激酶信号与电解质平衡控制之间的关系
Brian J Harvey,Warren Thomas
Brian J Harvey
Aldosterone acts through the mineralocorticoid receptor (MR) to modulate gene expression in target tissues. In the kidney, the principal action of aldosterone is to promote sodium conservation in the distal nephron and so indirectly enhance...
Synthesis of novel hybrid steroid dimers by BF3·Et2O-catalyzed aldol condensation of 2-formyl-estradiol diacetate and steroid sapogenins [0.03%]
新型杂化固醇双体的合成：BF3·Et2O催化下2-甲醛雌二醇二乙酸酯与固醇配糖体的缩合反应
Manuel A Ramos-Enríquez,Martín A Iglesias-Arteaga
Manuel A Ramos-Enríquez
BF3·Et2O-catalyzed aldol condensation of steroid sapogenins with 2-formyl-estradiol diacetate afforded two novel classes of steroid dimers in which an estrogenic core is attached to the spirostanic side chain of an steroid sapogenin throug...
Corticosteroid therapy exacerbates the reduction of melatonin in multiple sclerosis [0.03%]
糖皮质激素治疗加重了多发性硬化症中褪黑素的减少现象
Shima Dokoohaki,Majid Ghareghani,Amir Ghanbari et al.
Shima Dokoohaki et al.
Objectives: Corticosteroid therapy is employed in multiple sclerosis (MS), a neurological abnormality characterized by an inflammatory process. Melatonin, a potent sleep-promoting and circadian phase regulatory hormone, i...
Chemical synthesis of 7α-hydroxypregnenolone, a neuroactive steroid that stimulates locomotor activity [0.03%]
具有促进运动作用的神经活性类固醇7α-羟基孕烯醇龙的化学合成
Francis K Yoshimoto,Hadi D Arman,Wendell P Griffith et al.
Francis K Yoshimoto et al.
7α-Hydroxypregnenolone is an endogenous neuroactive steroid that stimulates locomotor activity. A synthesis of 7α-hydroxypregnenolone from pregnenolone, which takes advantage of an orthogonal protecting group strategy, is described. In de...
Exercise attenuates dexamethasone-induced hypertension through an improvement of baroreflex activity independently of the renin-angiotensin system [0.03%]
运动通过改善血压调节反射功能减轻地塞米松致高血压作用且独立于肾素血管紧张素系统的作用之外
Paula B Constantino,Thiago J Dionísio,Francine Duchatsch et al.
Paula B Constantino et al.
Dexamethasone-induced hypertension may be caused by baroreflex alterations or renin-angiotensin system (RAS) exacerbation. Aerobic training has been recommended for hypertension treatment, but the mechanisms responsible for reduction of art...
Temporal expression and gonadotropic regulation of aromatase and estrogen receptors in the ovary of wall lizard, Hemidactylus flaviviridis: Correlation with plasma estradiol and ovarian follicular development [0.03%]
壁虎卵巢芳香化酶和雌激素受体的时空表达及促性腺激素调节：与血浆雌二醇浓度及卵泡发育的关系
Mamta Tripathy,Umesh Rai
Mamta Tripathy
The current study in Indian wall lizard Hemidactylus flaviviridis for the first time demonstrates the reproductive phase-dependent expression pattern of aromatase (cyp19) and estrogen receptor subtypes (er-α and er-β) as well as their gon...
Fungal biotransformation of diuretic and antihypertensive drug spironolactone with Gibberella fujikuroi, Curvularia lunata, Fusarium lini, and Aspergillus alliaceus [0.03%]
粗糙链孢霉、月牙柱孢霉、淡紫拟青霉和大蒜伯克霍尔德菌转化利尿和降压药物螺内酯
Amal Al-Aboudi,Belal Muneeb Kana&#x;an,Musa Abu Zarga et al.
Amal Al-Aboudi et al.
Derivatives of spironolactone (1), a diuretic and antihypertensive drug, were synthesized by using fungal cells for the first time. Ten different fungi were screened for their ability to biotransform 1, four of which were able to produce me...
Design, synthesis and antiproliferative effect of 17β-amide derivatives of 2-methoxyestradiol and their studies on pharmacokinetics [0.03%]
2-甲氧基雌二醇-17β-酰胺衍生物的设计合成及其抗增殖活性与药代动力学研究
Xiufang Shi,Zhihao Wang,Feng Xu et al.
Xiufang Shi et al.
A series of 17β-amide-2-methoxyestradiol compounds were synthesized with an aim to enhance the antiproliferative effect of 2-methoxyestradiol. The antiproliferative activity of 2-methoxyestradiol analogs against human cancer cells was inve...
Regulation of the membrane structure by brassinosteroids and progesterone in winter wheat seedlings exposed to low temperature [0.03%]
低温胁迫下丁布和孕酮对冬小麦幼苗膜结构的调控作用
Maria Filek,Elżbieta Rudolphi-Skórska,Apolonia Sieprawska et al.
Maria Filek et al.
Steroids constitute one of the most important groups of compounds of regulatory properties both in the animal and plant kingdom. In plants, steroids such as brassinosteroids or progesterone, by binding to protein receptors in cell membranes...
Baeyer-Villiger reaction of steroid sapogenins by CF3COOH-H2O2. A short cut to pregnan-3β,16β,20-triol 3-monoacetates [0.03%]
用CF3COOH-H2O2使甾体皂甙元进行Baeyer-Villiger反应直接合成孕烷三醇单 acetate类化合物的新方法研究
Katherine Vargas-Romero,Oscar Alberto,Marcos Flores-Álamo et al.
Katherine Vargas-Romero et al.
Treatment of steroid sapogenins with H2O2 in CF3COOH for 15min followed by reflux in CH3OH/H2O afforded good yields of pregnan-3β,16β,20-triol 3-monoacetates. When the hydrolysis step was carried out with KOH in refluxing methanol excelle...