Rania S Sulaiman,Mahita Kadmiel,John A Cidlowski
Rania S Sulaiman
Glucocorticoids (GCs) are essential steroid hormones that regulate numerous metabolic and homeostatic functions in almost all physiological systems. Synthetic glucocorticoids are among the most commonly prescribed drugs for the treatment of...
Non-protein amino acid derivatives of 25-methoxylprotopanaxadiol/25-hydroxyprotopanaxadioland their anti-tumour activity evaluation [0.03%]
25-甲氧基原人参二醇/25-羟基原人参二醇的非蛋白质氨基酸衍生物及其抗肿瘤活性评价
Weihui Yuan,Junhui Guo,Xude Wang et al.
Weihui Yuan et al.
As active components of ginseng, 25-methoxylprotopanaxadiol and 25-hydroxyprotopanaxadiol exhibited an ability to inhibit the growth and proliferation or to induce the differentiation and apoptosis of tumour cells. We modified 25-OCH3-PPD a...
Megan L Stefkovich,Yukitomo Arao,Katherine J Hamilton et al.
Megan L Stefkovich et al.
Non-genomic effects of estrogen receptor α (ERα) signaling have been described for decades. However, the mechanisms and physiological processes resulting solely from non-genomic signaling are poorly understood. Challenges in studying thes...
Stigmasterol: An adjuvant for beta lactam antibiotics against beta-lactamase positive clinical isolates [0.03%]
植物固醇(stigmasterol)可增强β-内酰胺类抗生素对临床耐药菌的抗菌活性
Tong Woei Yenn,Muhammad Arslan Khan,Nur Amiera Syuhada et al.
Tong Woei Yenn et al.
The emergence of beta lactamase producing bacterial strains eliminated the use of beta lactam antibiotics as chemotherapeutic alternative. Beta lactam antibiotics can be coupled with non-antibiotic adjuvants to combat these multidrug resist...
Roberta de Souza Santos,Aaron P Frank,Deborah J Clegg
Roberta de Souza Santos
The influence of sex on cellular function and metabolism is often ill defined in many human and animal studies. The National Institute of Health (NIH) recognized this gap in scientific knowledge and mandated that sex be factored into the de...
N-terminal truncations in sex steroid receptors and rapid steroid actions [0.03%]
性类固醇受体的N末端截短及其快速类固醇作用
Derek A Schreihofer,Phong Duong,Rebecca L Cunningham
Derek A Schreihofer
Sex steroid receptors act as ligand activated nuclear transcription factors throughout the body, including the brain. However, post-translational modification of these receptors can direct them to extranuclear sites, including the plasma me...
Karen L Chen,Zeynep Madak-Erdogan
Karen L Chen
Due to declining estrogen levels during menopause, NAFLD prevalence is higher in postmenopausal women compared to in premenopausal women or in men. Postmenopausal women are more susceptible to weight gain, fat redistribution and dyslipidemi...
Amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid [0.03%]
(3β,17β)-3-羟基雄甾-5-烯-17-甲酸的两亲性衍生物
Zülal Özdemir,Uladzimir Bildziukevich,David Šaman et al.
Zülal Özdemir et al.
A series of amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid (1) with the polyamine spermine and three other diamines, 1,2-diaminoethane, piperazine and cadaverine, were synthesized and their antimicrobial act...
Xiaoting Ma,Stephen R Hammes
Xiaoting Ma
Paxillin is a group III LIM domain protein that is best characterized as a cytoplasmic scaffold/adaptor protein that functions primarily as a mediator of focal adhesion. However, emerging studies indicate that paxillin's functions are far b...
Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB) and Cancer: A Novel Potential Therapeutic Target [0.03%]
糖蛋白非转移性黑色素瘤蛋白B(GPNMB)与癌症：%E2%80%9C一个潜在的新型治疗靶点%E2%80%9D
Manisha Taya,Stephen R Hammes
Manisha Taya
Glycoprotein non-metastatic melanoma protein B (GPNMB) is a transmembrane protein enriched on the cell surface of cancer cells, including melanoma, glioblastoma, and triple-negative breast cancer. There is growing evidence identifying GPNMB...