Membrane estrogen receptor signaling impacts the reward circuitry of the female brain to influence motivated behaviors [0.03%]
膜雌激素受体信号影响女性大脑的奖赏回路，进而影响动机行为
Katherine R Tonn Eisinger,Erin B Larson,Marissa I Boulware et al.
Katherine R Tonn Eisinger et al.
Within the adult female, estrogen signaling is well-described as an integral component of the physiologically significant hypothalamic-pituitary-gonadal axis. In rodents, the timing of ovulation is intrinsically entwined with the display of...
Comparison of [17(20)E]-21-Norpregnene oxazolinyl and benzoxazolyl derivatives as inhibitors of CYP17A1 activity and prostate carcinoma cells growth [0.03%]
[17(20)E]-21-诺孕烷氧杂环丁基和苯并氧杂环丁基衍生物作为CYP17A1活性及前列腺癌细胞生长的抑制剂的比较研究
Vladimir A Zolottsev,Yaroslav V Tkachev,Alexandra S Latysheva et al.
Vladimir A Zolottsev et al.
Four new 4,5-dihydro-1,3-oxazole, and four new benzo-[d]-oxazole derivatives of [17(20)E]-21-norpregnene, differing in the structure of steroid moiety, were synthesized and evaluated for their potency to inhibit 17α-hydroxylase/17,20-lyase...
Comparative Study
Steroids. 2018 Jan:129:24-34. DOI:10.1016/j.steroids.2017.11.009 2018
H M Rivera,T L Stincic
H M Rivera
This review lays out the evidence for the role of E2 in homeostatic and hedonic feeding across several species. While significant effort has been expended on homeostatic feeding research, more studies for hedonic feeding need to be conducte...
Synthesis and antimalarial activity of 3'-trifluoromethylated 1,2,4-trioxolanes and 1,2,4,5-tetraoxane based on deoxycholic acid [0.03%]
基于脱氧胆酸的3-三氟甲基化1,2,4-三噁烷和1,2,4,5-四噁烷的合成及其抗疟活性研究
Emil Yu Yamansarov,Dmitri V Kazakov,Natal&#x;ya I Medvedeva et al.
Emil Yu Yamansarov et al.
A series of new steroidal peroxides - 3'-trifluoromethylated 1,2,4-trioxolanes and 1,2,4,5-tetraoxanes based on deoxycholic acid were prepared via the reactions of the Griesbaum coozonolysis and peroxycondensation, respectively. 1,2,4-Triox...
Hannah Weber,Michael J Garabedian
Hannah Weber
Mediator is a conserved, multi-subunit macromolecular machine divided structurally into head, middle, and tail modules, along with a transiently associating kinase module. Mediator functions as an integrator of transcriptional regulatory ac...
The collective influence of 1, 25-dihydroxyvitamin D3 with physiological fluid shear stress on osteoblasts [0.03%]
生理水平流动剪切应力与1, 25-二羟基维生素D3对成骨细胞的联合作用的影响
Yan Li,Jiafeng Yuan,Qianwen Wang et al.
Yan Li et al.
1, 25-dihydroxyvitamin D3 (1, 25 (OH)2 D3) and mechanical stimuli in physiological environment contributes greatly to osteoporosis pathogenesis. Wide investigations have been conducted on how 1, 25-dihydroxyvitamin D3 and mechanical stimuli...
Irina Lerman,Stephen R Hammes
Irina Lerman
Myeloid cell production within the bone marrow is accelerated in the setting of cancer, and the numbers of circulating and infiltrating neutrophils and granulocytic myeloid derived suppressor cells (MDSCs) correlate with tumor progression a...
Communication between genomic and non-genomic signaling events coordinate steroid hormone actions [0.03%]
基因组信号事件与非基因组信号事件的交流协调类固醇激素的作用
Sandi R Wilkenfeld,Chenchu Lin,Daniel E Frigo
Sandi R Wilkenfeld
Steroid hormones are lipophilic molecules produced in one cell that can travel great distances within the body to elicit biological effects in another cell. In the canonical pathway, steroid hormone binding to a nuclear receptor (NR), often...
Membrane estrogen receptors signal to determine transcription factor function [0.03%]
膜雌激素受体信号的传递决定了转录因子的功能
Ellis R Levin
Ellis R Levin
Estrogen receptors (ER) alpha and beta as well as many other steroid receptors are found both within the nucleus and outside the nucleus. This includes extra-nuclear receptors in many organelles, including mitochondria, endoplasmic reticulu...
Effect of 17β-estradiol on estrogen receptor negative breast cancer cells in an osteolytic mouse model [0.03%]
17β-雌二醇对骨溶性小鼠模型中雌激素受体阴性的乳腺癌细胞的影响
D Joshua Cohen,Vaidehi Patel,Anjali Verma et al.
D Joshua Cohen et al.
17β-Estradiol (E2) promotes metastasis of triple negative breast cancer cells to bone. Recent studies show many triple negative breast cancer cell lines lacking the 66 kDa estrogen receptor (ER) alpha (ERα66) or its splice variant ERα46,...