The response of C19- and some C21-steroids during Synacthen and insulin tolerance test [0.03%]
C19和某些C21类固醇在合成促肾上腺皮质激素和胰岛素耐受性试验中的反应
Kateřina Šimůnková,Michaela Dušková,Lucie Kolatorova et al.
Kateřina Šimůnková et al.
Testing of the adrenal function with ACTH 1-24 (Synacthen test) or insulin (insulin tolerance test-ITT) is commonly used. The question of ongoing debate is the dose of Synacthen. Moreover, it may be important from the physiological point of...
The effect of acute and chronic exercise on steroid hormone fluctuations in young and middle-aged men [0.03%]
急性及慢性运动对年轻及中年男性类固醇激素波动的影响
Maha Sellami,Wissem Dhahbi,Lawrence D Hayes et al.
Maha Sellami et al.
The current study examine the effects of combined sprint and resistance training on serum total testosterone (TT), sex-hormone-binding globulin (SHBG) and cortisol (C), at rest, and in response to the Wingate Anaerobic-Test (WAnT) in 21 and...
Randomized Controlled Trial
Steroids. 2018 Apr:132:18-24. DOI:10.1016/j.steroids.2018.01.011 2018
Membrane-initiated estrogen signaling via Gq-coupled GPCR in the central nervous system [0.03%]
中枢神经系统中通过Gq偶联的GPCR介导的雌激素膜信号通路
Gwyndolin Vail,Troy A Roepke
Gwyndolin Vail
The last few decades have revealed increasing complexity and depth to our knowledge of receptor-mediated estrogen signaling. Nuclear estrogen receptors (ERs) ERα and ERβ remain the fundamental dogma, but recent research targeting membrane...
Acute interruption of treatment with nandrolone decanoate is not sufficient to reverse cardiac autonomic dysfunction and ventricular repolarization disturbances in rats [0.03%]
黄体酮癸酸酯急性停药不足以逆转雄烯二醇对大鼠心脏自主神经功能和心室复极紊乱的影响
Moacir Marocolo,Julio A Silva-Neto,Octávio Barbosa Neto
Moacir Marocolo
Anabolic androgenic steroids are a class of synthetic compounds derived from testosterone, eventually used by athletes, to improve physical performance. However, anabolic steroids can also modify normal cardiovascular function. Thus, we inv...
Photoprotection of ultraviolet-B filters: Updated review of endocrine disrupting properties [0.03%]
紫外线B防晒剂的光保护作用：内分泌干扰特性最新评论
Margarida Lorigo,Melissa Mariana,Elisa Cairrao
Margarida Lorigo
The Ultraviolet (UV) radiation is emitted by the sun and is part of the electromagnetic spectrum. There are three types of UV rays (UV-A, UV-B and UV-C), however only UV-A and UV-B have biologic effects in humans, with UV-B radiation being ...
Synthesis and cytotoxic effect of pregnenolone derivatives with one or two α,β-unsaturated carbonyls and an ester moiety at C-21 or C-3 [0.03%]
含一个或两个α,β-不饱和羰基及C-21或C-3酯基孕甾酮衍生物的合成及其细胞毒活性
Alejandra Chávez-Riveros,Abigail Cruz Noriega,María Teresa Ramírez Apan et al.
Alejandra Chávez-Riveros et al.
Four series of pregnenolone derivatives having one or two α,β-unsaturated carbonyls and an ester moiety at C-21 or C-3 were synthetized to compare their cytotoxicity effect. The final compounds were evaluated on three human cancer cell li...
Microbial biotransformation of bioactive and clinically useful steroids and some salient features of steroids and biotransformation [0.03%]
生物活性及临床应用类固醇的微生物生物转化及其显著特征
Nighat Sultana
Nighat Sultana
Steroids are perhaps one of the most widely used group of drugs in present day. Beside the established utilization as immunosuppressive, anti-inflammatory, anti-rheumatic, progestational, diuretic, sedative, anabolic and contraceptive agent...
Three new withanolides from the calyces of Nicandra physaloides [0.03%]
尼克拉nda physaloides的3个_withanolides 系统化命名化合物化学成分研究
Qin Xiao,Cui-Fang Wang,Jun Chen et al.
Qin Xiao et al.
Chemical investigation on ethyl acetate extract of the calyces of Nicandra physaloides resulted in the isolation of three new withanolides named as nicphysatone A (1), nicphysatone B (2), nicphysatone C (3), together with five known withano...
Taraxerol as a possible therapeutic agent on memory impairments and Alzheimer's disease: Effects against scopolamine and streptozotocin-induced cognitive dysfunctions [0.03%]
塔拉辛作为治疗记忆障碍和阿尔茨海默病的潜在药物：对抗东莨菪碱和链脲佐菌素诱导的认知功能障碍的作用
Talita Elisa Berté,Ana Paula Dalmagro,Priscila Laiz Zimath et al.
Talita Elisa Berté et al.
Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive impairment and cholinergic neuronal death, characteristic of the effect of time on biochemical neuronal function. The use of medicinal plants as an alternati...
Synthesis of new sarsasapogenin derivatives with antiproliferative and apoptotic effects in MCF-7 cells [0.03%]
具有抗增殖和促凋亡作用的新型沙门醇衍生物合成及评价研究
Wenbao Wang,Yingying Zhang,Guodong Yao et al.
Wenbao Wang et al.
Sarsasapogenin, a kind of mainly effective component of Anemarrhena asphodeloides Bunge, possesses good antitumor properties. Two series of new sarsasapogenin derivatives were synthesized and evaluated for their cytotoxicities against three...