Synthesis of novel 17-triazolyl-androst-5-en-3-ol epimers via Cu(I)-catalyzed azide-alkyne cycloaddition and their inhibitory effect on 17α-hydroxylase/C17,20-lyase [0.03%]
通过Cu（I）催化的叠氮化物-炔烃环加成合成新型17-三唑基-雄甾-5-烯-3-醇差向异构体及其对17α-羟化酶/C17,20-裂解酶的抑制作用
Anita Kiss,Bianka Edina Herman,Tamás Görbe et al.
Anita Kiss et al.
The regioselective Cu(I)-catalyzed 1,3-dipolar cycloaddition of 17α- and 17β-azidoandrost-5-en-3β-ol epimers (3b and 5b) with different terminal alkynes afforded novel 1,4-substituted triazolyl derivatives (8a-k and 9a-k). For the prepar...
Rapid Signaling and Genomic Steroid Hormone Actions in Health and Disease [0.03%]
健康与疾病状态下的类固醇激素信号转导和基因组作用机制研究
Stephen R Hammes
Stephen R Hammes
Editorial
Steroids. 2018 May:133:1. DOI:10.1016/j.steroids.2018.03.002 2018
Antidepressant effects of magnolol in a mouse model of depression induced by chronic corticosterone injection [0.03%]
肉桂酸茋生物碱 magnolol 的抗抑郁作用及机制研究
Yongtao Bai,Lihua Song,Guoliang Dai et al.
Yongtao Bai et al.
Evidence showed that the stress hormone corticosterone (CORT) injection resulted in dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis implicated in major depressive disorder. Magnolol, main constituent identified in the barks o...
Ionotropin is the mammalian digoxin-like material (DLM). It is a phosphocholine ester of a steroid with 23 carbon atoms [0.03%]
离子素是哺乳动物的_DIG物质。它是一种具有23个碳原子的类固醇磷酸胆碱酯
Fred Chasalow,Lori Pierce-Cohen
Fred Chasalow
We describe a novel steroid, which we have named "Ionotropin". Its unique features are: [1] it has 23 carbon atoms and [2] it is a phosphocholine ester. There are no other known mammalian steroids with either structural feature. Ionotropin ...
Comparison of blood sampling methods for plasma corticosterone measurements in mice associated with minimal stress-related artefacts [0.03%]
与最小压力相关的假象有关的小鼠血浆皮质酮测定的血液采样方法比较
Sarah Kim,Daphne Foong,Mark S Cooper et al.
Sarah Kim et al.
Accurate measurement of circulating glucocorticoid concentrations in rodents is often hampered by the stress-related activation of the hypothalamic-pituitaryadrenal axis during animal handling. The present study aims to identify methods of ...
Comparative Study
Steroids. 2018 Jul:135:69-72. DOI:10.1016/j.steroids.2018.03.004 2018
Vitamin D deficiency and vitamin D receptor variants in mothers and their neonates are risk factors for neonatal sepsis [0.03%]
母亲及新生儿的维生素D缺乏和维生素D受体变异是新生儿败血症的风险因素
Safaa I Tayel,Shimaa E Soliman,Hanan M Elsayed
Safaa I Tayel
Background and aim: Increasing prevalence of neonatal sepsis in recent years catch attention to early prevention and management. Vitamin D receptor (VDR) polymorphism can modulate VDR expression level that greatly influen...
Phase 1 trial of vamorolone, a first-in-class steroid, shows improvements in side effects via biomarkers bridged to clinical outcomes [0.03%]
一类新型类固醇药物vamorolone一期临床试验显示通过生物标志物改善副作用并联到临床结果中
Eric P Hoffman,Valerie Riddle,Maxime A Siegler et al.
Eric P Hoffman et al.
Background: Glucocorticoid drugs are highly effective anti-inflammatory agents, but chronic use is associated with extensive pharmacodynamic safety concerns that have a considerable negative impact on patient quality of l...
Clinical Trial
Steroids. 2018 Jun:134:43-52. DOI:10.1016/j.steroids.2018.02.010 2018
Stereoselective synthesis of the four 16-hydroxymethyl-3-methoxy- and 16-hydroxymethyl-3-benzyloxy-13α-estra-1,3,5(10)-trien-17-ol isomers and their antiproliferative activities [0.03%]
四個16-羥基甲基-3-烷氧基-13α-雌-1，3，5（10）-三烯-17-醇異構體的立體選擇性合成及其抗增殖活性研究
Anita Kiss,Erzsébet Mernyák,János Wölfling et al.
Anita Kiss et al.
The reduction of 16-hydroxymethylene-3-methoxy-13α-estra-1,3,5(10)-trien-17-one (14) and 16-hydroxymethylene-3-benzyloxy-13α-estra-1,3,5(10)-trien-17-one (16) yielded a mixture of two diastereomeric diols, the 16α-hydroxymethyl,17β-hydr...
Involvement of adenosine monophosphate activated kinase in interleukin-6 regulation of steroidogenic acute regulatory protein and cholesterol side chain cleavage enzyme in the bovine zona fasciculata and zona reticularis [0.03%]
AMP活化蛋白激酶在牛束状带和网状带中白细胞介素-6调节类固醇急性调节蛋白和胆固醇侧链裂解酶中的作用
Matharage S I De Silva,Adam W Dayton,Lance R Rhoten et al.
Matharage S I De Silva et al.
In bovine adrenal zona fasciculata (ZF) and NCI-H295R cells, interleukin-6 (IL-6) increases cortisol release, increases expression of steroidogenic acute regulatory protein (StAR), cholesterol side chain cleavage enzyme (P450scc), and stero...
The ER-α36/EGFR signaling loop promotes growth of hepatocellular carcinoma cells [0.03%]
ER-α36/EGFR信号通路促进肝癌细胞增殖
Hui You,Kun Meng,Zhao-Yi Wang
Hui You
Hepatocellular carcinoma (HCC) is the common primary liver cancer and the third leading cause of cancer related mortality worldwide. It is generally thought that the estrogen-signaling pathway is not related to the development and progressi...