Nandrolone decanoate induces heart injury via oxidative damage and mitochondrial apoptotic pathway by regulation of TLR4/NF-κB/NLRP3 axis in male rats: The rescue effect of N-acetylcysteine [0.03%]
雄性大鼠睾酮过多诱导心肌损伤的机制及N-乙酰半胱氨酸干预的效果研究
Haniyeh Amini,Alireza Shirpoor,Roya Naderi
Haniyeh Amini
Myocardial apoptosis is a leading cause of damage in cardiac tissues of nandrolone (ND) treatment. However, its molecular mechanism is not fully understood. This study aims to investigate the effect of ND with or without N -acetylcysteine (...
Novel compound heterozygous CYP17A1 mutations identified in a family with two siblings affected by 17α-hydroxylase/17,20-lyase deficiency [0.03%]
CYP17A1双杂合突变导致的17α-羟化酶/17，20-裂解酶缺乏症家系报告
Rongbo He,Lin Xu,Nan Yang et al.
Rongbo He et al.
Background: 17α-Hydroxylase/17,20-lyase deficiency (17OHD) is a rare form of congenital adrenal hyperplasia (CAH), caused by mutations in the CYP17A1 gene. It typically manifests clinically as variable degree of hyperten...
Effect of estrogen on myocardial ischemia-reperfusion injury in male and female rats and related mechanism [0.03%]
雌激素对大鼠缺血再灌注损伤的影响及机制研究
Sichong Chen,Lijuan Yang,Jiayao Xue et al.
Sichong Chen et al.
Due to the difference of estrogen levels in different phases of estrous cycle, it is necessary to exclude the influence of endogenous estrogen when studying the cardiovascular effects of estrogen and its analogues. In this study, the ischem...
Improved synthesis and characterization of bile acid esters: Organogelation and supramolecular properties [0.03%]
胆酸酯的改进合成与表征：有机凝胶和超分子性能
Jair García-Méndez,Adolfo López-Torres,María A Fernández-Herrera
Jair García-Méndez
Bile acid esters and their derivatives hold significant interest due to their applications in fields such as supramolecular chemistry, biomedicine, and nanomaterials. This study revisits the synthesis and characterization of esters derived ...
Pancreastatin inhibitor PSTi8 improves ovarian health in Letrozole-HFD induced PCOS rats by ameliorating metabolic and reproductive parameters [0.03%]
胰腺抑素抑制剂PSTi8通过改善代谢和生殖参数来改善来曲唑联合高脂饮食诱导的多囊卵巢综合征大鼠的卵巢健康
Shubhi Yadav,Shailesh Dadge,Richa Garg et al.
Shubhi Yadav et al.
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder associated with insulin resistance (IR) and hyperandrogenism. IR plays a crucial role in the etiology of PCOS. An insulin-sensitizing agent like metformin ...
The effect of resistance training and nandrolone decanoate administration on cardiac tissue in mice [0.03%]
电阻训练和十一酸萘夫西林对小鼠心脏组织的影响
Yechiel Atias,Tavor Ben-Zeev,Chagai Levi et al.
Yechiel Atias et al.
Purpose: This study examined the effect of resistance training (RT) by itself and in combination with supraphysiological administration of nandrolone decanoate (ND) on the inflammatory, apoptotic, and oxidative stress res...
Chronic treatment with nandrolone decanoate reduces left ventricular contractile response even when combined with strength training [0.03%]
1-脱氢甲基睾丸素联合力量训练会减少左心室收缩反应
Lucas D Ferreira,Bruno A Aguilar,João V M Bernal et al.
Lucas D Ferreira et al.
Introduction: The use of anabolic steroids is widely adopted for aesthetic purposes and sports performance. In supraphysiological doses, they can impair various physiological systems. However, we know little about their e...
Structural and functional characterization of genes and enzymes involved in withanolide biosynthesis in Physalis alkekengi L [0.03%]
毛酸浆-Withanolide生物合成相关基因和酶的结构与功能分析
Swati Gupta,Bashir Akhlaq Akhoon,Deepak Sharma et al.
Swati Gupta et al.
Physalis alkekengi L. is recognized as a significant source of various secondary metabolites, particularly C28 steroidal lactones known as withanolides and physalins, renowned for their therapeutic properties with a rich history in traditio...
The advancement of structure, bioactivity, mechanism, and synthesis of bufotalin [0.03%]
bufotalin的结构、活性、机制及合成研究进展
Nuo Chen,Yunqiang Wu,Huamao Wei et al.
Nuo Chen et al.
Toad venom, a family of toxic yet pharmacologically valuable biotoxins, has long been utilized in traditional medicine and holds significant promise in modern drug development. Bufotalin, a prominent bufotoxin, has demonstrated potent cytot...
Acetate abates adipose-ovarian endocrinometabolic disturbance in experimentally induced polycystic ovarian syndrome [0.03%]
醋酸盐缓和实验性多囊卵巢综合征诱导的脂肪-卵巢内分泌代谢紊乱
Kehinde S Olaniyi,Stephanie E Areloegbe,Mohd Z Ul Haq Shah
Kehinde S Olaniyi
Background: Besides ovarian dysfunction and infertility, individuals with polycystic ovarian syndrome (PCOS) also present a number of systemic disturbances including functional derangements in the adipose tissue which pos...