Synthesis, pharmacological evaluation and docking studies of progesterone and testosterone derivatives as anticancer agents [0.03%]
作为抗癌症试剂的黄体酮和睾丸素衍生物的合成、药理评价及对接研究
Muafia Jabeen,Muhammad Iqbal Choudhry,Ghulam Abbas Miana et al.
Muafia Jabeen et al.
Steroidal hormones progesterone and testosterone play a vital role in breast and prostate cancers. In this research, we have synthesized and characterized a total of thirty-one (31) new nitrogenous derivatives of progesterone and testostero...
Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol [0.03%]
2-甲氧基雌二醇类似物的合成、分子建模及其生物活性评估
Nora Al-Kazaale,Phuong T Tran,Farhad Haidari et al.
Nora Al-Kazaale et al.
The endogenous steroid 2-methoxyestradiol (1) has attracted a great interest as a lead compound towards the development of new anti-cancer drugs. Herein, the synthesis, molecular modeling, anti-proliferative and anti-angiogenic effects of t...
Two new cytotoxic steroids from the Chinese soft coral Sinularia sp [0.03%]
中国海绵Sinularia.sp中两种新的细胞毒类固醇成分
Song-Wei Li,Wen-Ting Chen,Li-Gong Yao et al.
Song-Wei Li et al.
Two new steroids, ximaosteroid E (1) and ximaosteroid F (2), along with two known related compounds (3 and 4), were isolated from the Chinese soft coral Sinularia sp. Notably, 1 possesses an uncommon dihydrofuran group. Their structures wer...
Analysis of the impact of corticosteroids adjuvant treatment during experimental invasive meningococcal infection in mice [0.03%]
小鼠实验性侵袭性脑膜炎球菌感染中糖皮质激素辅助治疗的影响分析
Michaël Levy,Ala-Eddine Deghmane,Myriam Aouiti-Trabelsi et al.
Michaël Levy et al.
Invasive meningococcal disease (IMD) is usually associated with intense inflammatory response that is correlated with severe infection. Corticosteroids may regulate this inflammatory response through an early but transient induction of IL-1...
Eco-friendly microbial production of diosgenin from saponins in Dioscorea zingiberensis tubers in the presence of Aspergillus awamori [0.03%]
米曲霉存在下利用薯蓣皂苷从Dioscorea zingiberensis块茎绿色高效发酵生产地奥辛
Yu Chen,Yi Dong,Yuanlong Chi et al.
Yu Chen et al.
A novel microbial procedure was proposed for diosgenin production from Dioscorea zingiberensis C.H. Wright (DZW) tubers via employing Aspergillus awamori for the first time. The optimal conditions of fermenter cultivation were established a...
Seth Guller
Seth Guller
Effects of puerarin on estrogen-regulated gene expression in gonadotropin-releasing hormone pulse generator of ovariectomized rats [0.03%]
黄豆异黄酮朴克明对卵巢切除大鼠下丘脑促性腺激素释放激素脉冲发生器中雌激素调节基因表达的影响
Panida Loutchanwoot,Tina Vortherms
Panida Loutchanwoot
Effects of puerarin on the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator function is investigated, for the first time, in ovariectomized rats at the level of mRNA expression of estrogen-responsive genes, e.g., estrogen ...
Ching-Chung Tsai,Shu-Leei Tey,Li-Ching Chang et al.
Ching-Chung Tsai et al.
Most pregnant women have symptoms of gastroesophageal reflux disease (GERD) during pregnancy. Postmenopausal hormone replacement therapy is associated with GERD. The effects of estradiol on lower esophageal sphincter (LES) motility and GERD...
A novel gene expression analytics-based approach to structure aided design of rexinoids for development as next-generation cancer therapeutics [0.03%]
一种基于基因表达分析的新型雷沙立德的设计方法以用于下一代癌症治疗药物研发研究
Bentley J Hanish,Jennifer F Hackney Price,Ichiro Kaneko et al.
Bentley J Hanish et al.
Rexinoids are powerful ligands that bind to retinoid-X-receptors (RXRs) and show great promise as therapeutics for a wide range of diseases, including cancer. However, only one rexinoid, bexarotene (Targretin TM) has been successfully trans...
Antimicrobial cholic acid derivatives from the Pitch Lake bacterium Bacillus amyloliquefaciens UWI-W23 [0.03%]
来自_pitch湖_芽孢杆菌_Bacillusanmliquefaciens_UWI-W23_的抗菌胆酸衍生物
Tresha E Dobson,Anderson R Maxwell,Adesh Ramsubhag
Tresha E Dobson
Six cholic acid derivatives (1-6) were isolated from broth cultures of Bacillus amyloliquefaciens UWI-W23, an isolate from the Trinidad Pitch Lake. The compounds were extracted via solvent extraction and/or XAD resin adsorption and purified...