Jumpei Fujiki,Naoyuki Maeda,Michiko Sato et al.
Jumpei Fujiki et al.
Corticosterone (CORT), the major glucocorticoid in rodents, is secreted from the adrenal gland, affects various organs in the body and regulates energy metabolism as a stress response. Although local steroidogenesis of androgens and estroge...
Cytotoxic steroids from the Vietnamese gorgonian Verrucella corona [0.03%]
越南产石芝 verrucella corona 的细胞毒类固醇化合物研究
Nguyen Hoai Nam,Ninh Thi Ngoc,Tran Thi Hong Hanh et al.
Nguyen Hoai Nam et al.
Using various chromatographic separations, seventeen steroids including seven new compounds, verrucorosteroids A-F (1-6) and verrucorosterone (7), were isolated from the Vietnamese gorgonian Verrucella corona. Their structures were elucidat...
Optimization of the synthesis of a key intermediate for the preparation of glucocorticoids [0.03%]
一种皮质激素药物关键中间体的工艺优化方法
Romain Jouve,Vincent Thery,Sylvie Ducki et al.
Romain Jouve et al.
A short and efficient synthesis, based on a one-step double elimination, of a key intermediate in the synthesis of various glucocorticosteroids has been developed. This method can be carried out on large scale for further industrial applica...
Design and semisynthesis of new herbicide as 1,2,3-triazole derivatives of the natural maslinic acid [0.03%]
作为天然马斯林酸的1,2,3-三氮唑衍生物的新除草剂的设计和半合成
Aymen Ben Nejma,Mansour Znati,Adam Daich et al.
Aymen Ben Nejma et al.
Interesting biological activities (anti-inflammatory, anticancer, antiviral, antioxidant, antidiabetic…) have been reported for maslinic acid (MA) and MA-based compounds. In continuation of our previous work on MA, herbicide potential of T...
Xenoestrogen interference with nongenomic signaling actions of physiological estrogens in endocrine cancer cells [0.03%]
环境中的雌激素类似物干扰生理雌激素在内分泌癌细胞中的非基因组信号功能作用
Cheryl S Watson,Luke Koong,Yow-Jiun Jeng et al.
Cheryl S Watson et al.
Rapid nongenomic signaling by estrogens (Es), initiated near the cell membrane, provides new explanations for the potent actions of environmental chemicals that imperfectly mimic physiological Es. These pathways can affect tumor growth, sta...
Testosterone enhances expression and functional activity of epithelial sodium channel (ENaC), cystic fibrosis transmembrane regulator (CFTR) and sodium hydrogen exchanger (NHE) in vas deferens of sex-steroid deficient male rats [0.03%]
雄激素增强性类固醇缺乏大鼠输精管上皮钠通道、囊纤蛋白和钠氢交换器的表达及功能活性
Nur Siti Khadijah Ramli,Nelli Giribabu,Naguib Salleh
Nur Siti Khadijah Ramli
Effects of testosterone on expression and functional activity of ENaC, CFTR and NHE in vas deferens were investigated. Methods: Orchidectomized, adult mal...
1H NMR determination of adulteration of anabolic steroids in seized drugs [0.03%]
seized药物中雄性同化甾体类毒品的掺假测定:基于1H NMR的方法
Marcos Vinícius de Moura Ribeiro,Nivaldo Boralle,Lidiane Gaspareto Felippe et al.
Marcos Vinícius de Moura Ribeiro et al.
Counterfeiting and adulteration of pharmaceuticals is a prevalent problem worldwide and represents a major health risk to the population, with anabolic steroids being one of the main classes of drugs consumed and obtained from dubious sourc...
Hybrid of dehydroergosterol and nitrogenous alternariol derivative from the fungus Pestalotiopsis uvicola [0.03%]
来源于真菌Pestalotiopsis uvicola的脱氢麦角甾醇和含氮杂色曲霉素衍生物的杂合体
Guo-Mei Hou,Xiu-Mei Xu,Qian Wang et al.
Guo-Mei Hou et al.
A new hybrid of dehydroergosterol and nitrogenous alternariol derivative, pestauvicomorpholine A (1), and three alternariol analogues (2-4) including a new aminated one, pestauvicolactone A (2), were isolated from the fermentation product o...
Synthesis and evaluation of the antiproliferative activity of benzylidenes of 16-dehydroprogesterone series [0.03%]
合成并评估16-氢脱前列腺素系列茋衍生物抗增殖活性
Alexander M Scherbakov,Igor V Zavarzin,Svetlana K Vorontsova et al.
Alexander M Scherbakov et al.
Novel benzylidenes (chalcones) of the 16-dehydroprogesterone series have been characterized and their antitumor activity against two breast cancer cell lines was evaluated. Benzylidenes exhibit significant antiproliferative effect on cells ...
In silico identification of new potentially active brassinosteroid analogues [0.03%]
基于计算识别具有活性的新型 brassinosteroid 类似物
Elena Moreno-Castillo,Daniel P Ramírez-Echemendía,Giselle Hernández-Campoalegre et al.
Elena Moreno-Castillo et al.
Brassinosteroids (BRs) are hormones found in a wide range of plant species, they are synthesized at low concentrations and are essential for normal growth and development. These phytohormones are recognized by the Leucine-rich-repeat ectodo...