A bile acid derivative with PPARγ-mediated anti-inflammatory activity [0.03%]
一种通过PPARγ介导的具有抗炎活性的胆汁酸衍生物
Sen Liu,Ying Wang,Mingzhi Su et al.
Sen Liu et al.
During our search for bioactive secondary metabolites in the jellyfish-derived fungus Penicillium chrysogenum J08NF-4, several bile acid derivatives (2-6) were isolated along with a new steroidal artifact (1). An in vitro anti-inflammatory ...
Ana Carolina Momentti,Débora Estadella,Luciana Pellegrini Pisani
Ana Carolina Momentti
There is a growing concern about the impacts of hypovitaminosis D on the health of pregnant woman, fetal development, childhood, and adult life. Variations in maternal nutrition during gestation and/or lactation play a critical role in the ...
Baeyer-Villiger oxidation of progesterone by Aspergillus sojae PTCC 5196 [0.03%]
枯草曲霉PTCC 5196诱导孕酮发生贝耶尔-维利格尔氧化反应
Mehri Javid,Bahman Nickavar,Hossein Vahidi et al.
Mehri Javid et al.
Microbial transformations are capable of producing steroid substances difficult to synthesize by chemical methods. Strains belonging to the genus Aspergillus are effective facilitators of microbial biotransformations due to their enzymatic ...
First report of bioactive sterols from the muricid gastropod Chicoreus ramosus [0.03%]
首个来自海蜗牛Chicoreus ramosus的生物活性固醇报告
Soumya Salas,Kajal Chakraborty
Soumya Salas
Two unusual △5 sterols with unprecedented skeletons were isolated from the organic extract of muricid gastropod Chicoreus ramosus collected off the Gulf of Mannar Coast. This is the first report of isolation of bioactive sterols endowed wi...
Conjugates of 17-substituted testosterone and epitestosterone with pyropheophorbide a differing in the length of linkers [0.03%]
不同连接长度的17位取代睾丸素和表睾丸素与叶绿素a共轭物
Vladimir A Zolottsev,Gelii V Ponomarev,Maria O Taratynova et al.
Vladimir A Zolottsev et al.
Conjugates of 17α-substituted testosterone (1 and 2) and 17β-substituted epitestosterone (3 and 4) with pyropheophorbide a were synthesized. The scheme consisted of synthesis of 17α-hydroxy-3-oxopregn-4-en-21-oic and 17β-hydroxy-3-oxopr...
Nury Pérez-Hernández,Elvia Becerra-Martínez,Pedro Joseph-Nathan
Nury Pérez-Hernández
The 750 MHz 1H NMR spectrum of cholesteryl benzoate (1b) could be assigned completely, which means all chemical shifts and all coupling constants, including some long-range values, were established. This task was possible by extracting many...
Shardool Nair,Geetanjali Sachdeva
Shardool Nair
Metastatic cancer cells meet several physical, biochemical and immunological barriers before colonizing a new territory. Cancerous cells turn invasive, mobile and eventually disengage from their native niche. This is followed by their intra...
Crystal structures and Hirshfeld surface analyses of the hemi-hydrate and hemi-methanolate of 3α-hydroxy-16α-bromoandrostan-17-one, 3: Differences in supramolecular arrangements [0.03%]
3α-羟基-16α-溴雄甾-17-酮半水合物和半甲烷磺酸盐的晶体结构及Hirshfeld面分析：超分子排列方式的差异
Ligia R Gomes,John N Low,Alan B Turner et al.
Ligia R Gomes et al.
The crystal structures and Hirshfeld surface analyses of two hemi-solvates of 3α-hydroxy-16α-bromoandrostan-17-one, 3, namely [(3)2.(H2O)] and [(3)2.(MeOH)], are reported. Both solvates crystallize in the monoclinic space group, P21, with...
3,20-Dihydroxy-13α-19-norpregna-1,3,5(10)-trienes. Synthesis, structures, and cytotoxic, estrogenic, and antiestrogenic effects [0.03%]
3,20-二羟基-13α-19-孕甾-1,3,5（10）三烯的合成，结构及其细胞毒作用、雌激素和抗雌激素活性
Yury V Kuznetsov,Inna S Levina,Alexander M Scherbakov et al.
Yury V Kuznetsov et al.
New 3,20-dihydroxy-13α-19-norpregna-1,3,5(10)-trienes were synthesized. The effects of these compounds on breast cancer cells and ERα activation were investigated. The scaffold of compounds containing the six-membered ring D' annulated at...
Estrogen receptors and sex hormone binding globulin in neuronal cells and tissue [0.03%]
神经元细胞和组织中的雌激素受体和性激素结合球蛋白
Veronika M Gebhart,Jack D Caldwell,Andrea Rodewald et al.
Veronika M Gebhart et al.
Estrogens exert a critical influence on neuronal tissues and cells. As demonstrated in many clinical studies, estrogens are neuroprotective to the extent that they improve prognosis for women with neurodegenerative diseases. Unfortunately, ...