Evaluation of the short-term stability of 6α-chloro-testosterone, 6β-bromo-androstenedione and 6-oxo-androstenedione in dimethylsulfoxide and methanol using liquid and gas chromatography - mass spectrometry [0.03%]
使用液相色谱和气相色谱-质谱法评价6α-氯基睾酮，6β-溴基雄烯二酮和6-氧代雄烯二酮在二甲亚砜和甲醇中的短期稳定性
Dayamin Martínez Brito,Patrizia Leogrande,Xavier de la Torre et al.
Dayamin Martínez Brito et al.
This work studied the short-term stability of 6α-chloro-testosterone (6-CT), 6β-bromo-androstenedione (6-BrAED) and 6-oxo-androstenedione (6-oxo-AED) in methanol (MeOH) and dimethylsulfoxide (DMSO) solutions by gas and liquid chromatograp...
Qing-Jiang Xu,Jia-Chen Liu,Jia Xu et al.
Qing-Jiang Xu et al.
Three new diterpenoids, 12,16-epoxy-11-hydroxy-17(15 → 16)-abeo-abieta-8,11,13-trien-7-one (1), 7,12-dihydroxy abieta-6,8,10(5),11,13-quien-20-oic acid 1,20-lactone (2), labda-5(10),13(E)-dien-15-ol (11), one new natural product (2E,6E)-3,...
17β-estradiol delays cardiac aging through suppressing the methylation of Beclin1 in a murine model [0.03%]
17β-雌二醇通过抑制Beclin1的甲基化来延迟心脏衰老的过程中的小鼠模型研究
Lili Ye,Tianming Deng,Ruiyan Wang et al.
Lili Ye et al.
Introduction: Cardiac endogenous senescence will gradually change and aggravate with age. Recent research showed that 17β-estradiol (17β-E2), an estrogen with numerous biological activities including the prevention of v...
Theoretical study of the pyridyl-cholestane formation pathway using DFT: A stepwise mechanistic approach [0.03%]
使用DFT对吡啶基胆甾烷形成途径的理论研究：一种逐步机理方法
Kamlesh Sharma,Priyanka
Kamlesh Sharma
The reaction mechanism of the formation of pyridyl-cholestane derivative 4 from a multi-component reaction involving cholestane-6-one, aromatic aldehyde, malononitrile, and ammonium acetate in presence of magnesium oxide nanoparticles (MgO ...
New hydroxylated metabolite derived from the microbial biotransformation of 11α-acetoxyprogesterone by the endophytic fungus Phyllosticta sp. 16L1 and its cytotoxic activity [0.03%]
内生真菌Phyllosticta sp. 16L1代谢11α-醋酸氧孕酮产生的新型羟基化代谢物及其细胞毒性作用
Mufeda Ahmed Hazea Gazaem,Wan Nurul Nazneem Wan Othman,Syed Adnan Ali Shah et al.
Mufeda Ahmed Hazea Gazaem et al.
Biotransformations catalysed by microbes are promising approach for producing a vast library of structurally diverse chemical molecules with applications in the pharmaceutical industry. The biotransformation of 11α-acetoxyprogesterone (1) ...
Design and discovery of novel heteroaryl substituted pregnenolone derivatives as potent anti-neuroinflammatory agents targeting LPS-stimulated BV-2 microglial cells [0.03%]
新型异芳基孕烯醇衍生物的设计与发现作为强有力的抗神经炎症药物作用于LPS刺激的BV-2小胶质细胞
Siqi Xu,Ling Fang,Jianfeng Cai et al.
Siqi Xu et al.
A new family of steroidal compounds based on a heteroaryl-4,5-dihydropyrazole thiazolinone core structure was designed and synthesized through structural modifications. The anti-neuroinflammatory activity of these compounds was evaluated in...
Junwei Wang,Shuhui Wang,Meng Wang et al.
Junwei Wang et al.
Non-obstructive azoospermia (NOA) is the most common cause of male infertility, accounting for approximately 60 % of azoospermia cases. In recent years, gene mutations have emerged as the primary factor under investigation for the etiology ...
Steroids from the mushroom Ganoderma shandongense and their AChE inhibitory activities [0.03%]
灵芝类蘑菇及其乙酰胆碱酯酶抑制活性成分的研究
Yaqin Huo,Shiyuan Ma,Xihan He et al.
Yaqin Huo et al.
Investigation of the solid culture of Ganoderma shandongense led to the isolation of 15 compounds, including one new steroid (compound 1) and fourteen known ones (compounds 2-15). Their structures were determined via extensive the nuclear m...
Unraveling binding interactions between methasterone and bovine serum albumin (BSA): A spectroscopic and computational study [0.03%]
甲基睾丸素和牛血清白蛋白(BSA)之间的结合相互作用的光谱及计算研究
Sahar Khurshid,Saima Rasheed,Sven Falke et al.
Sahar Khurshid et al.
In this study, binding interactions between methasterone and bovine serum albumin (BSA) were analyzed using spectroscopic techniques and molecular docking. UV absorption spectroscopy showed the formation of a ground-state complex between me...
Effect of betulinic acid on MepA efflux pump inhibition in Staphylococcus aureus: Antibacterial and molecular study [0.03%]
齐墩果酸对金黄色葡萄球菌MepA外排泵抑制的影响：抗菌和分子研究
Camila Aparecida Pereira da Silva,Nara Juliana Santos Araújo,Cícera Datiane Morais Oliveira-Tintino et al.
Camila Aparecida Pereira da Silva et al.
Infections caused by pathogenic bacteria have been responsible for a significant number of deaths in recent decades. Invasive infections caused by Staphylococcus aureus are highly prevalent and have high morbidity and mortality rates. Faced...