Evaluation of the diagnostic value of G protein-coupled estrogen receptor (GPER) in COVID-19 cases at Tokat Province [0.03%]
评价G蛋白偶联雌激素受体（GPER）在托卡特省新冠肺炎病例中的诊断价值
Figen Guzelgul,Ergul Belge Kurutas
Figen Guzelgul
Objective: Factors affecting the clinical course of COVID-19, an infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, are still poorly understood. G protein-coup...
From root to Recovery: The role of herbs in polycystic ovary syndrome management [0.03%]
从根源到恢复：草药在多囊卵巢综合征管理中的作用
Noor-Ul-Ain Zafar,Rahmatullah Qureshi,Ayesha Siddiqa et al.
Noor-Ul-Ain Zafar et al.
Polycystic ovarian syndrome (PCOS) is a prevalent complicated endocrine condition affecting women, caused by both hereditary and environmental factors. It often emerges during the reproductive years (15-35 years) and now affects 1 out of 10...
Genetic insights into vitamin D deficiency: a case-control study of GC and CYP24A1 gene polymorphism [0.03%]
维生素D缺乏的遗传学见解——GC和CYP24A1基因多态性的病例对照研究
Usama,Aslam Khan,Muhammad Kashif Raza et al.
Usama et al.
Despite the sunny climate, vitamin D deficiency is highly prevalent in several parts of the world. Several risk factors are associated with VD deficiency, including single nucleotide polymorphism and post-translational modifications in its ...
Stress responses in blood donors: Oral fluid hormone dynamics and implications for donor support [0.03%]
血液捐赠者的压力反应：口腔液激素动态变化及对捐赠者支持的启示
Agata Alterio,Matteo Feltracco,Giovanna Mazzi et al.
Agata Alterio et al.
Glucocorticoids (cortisol and cortisone) hormones are potential biomarkers for monitoring physiological stress in humans. These hormones are released into the bloodstream but are also detectable in other biological matrixes such as oral flu...
Unleashing the pharmacological potential of taste receptors in reproductive processes beyond their gustatory role [0.03%]
释放味觉受体在生殖过程中的药理潜力超越其味觉作用
Nourhan Magdy,Noha F Abdelkader,Hala F Zaki et al.
Nourhan Magdy et al.
Traditionally, taste receptors (TRs) have been understood to reside within the taste buds on the tongue, serving as initiators for different taste perceptions. However, recent research has expanded our understanding, revealing that TRs are ...
BSS-4, a diosgenin analogue, reduces carrageenan-induced paw inflammation in rat [0.03%]
BSS-4（一种薯蓣皂苷元类似物）减少大鼠红藻氨酸诱导的足肿胀
Marisol Casimiro-Rosas,Irving Parra,Jesús Sandoval et al.
Marisol Casimiro-Rosas et al.
Inflammation is an adaptive response that ensures the survival of the organism in the face of injuries or trauma primarily via the immune system. However, overactivation of this process can be detrimental to the point of fatality. To overco...
Microbial steroid biotransformation: Regio- and stereo selective 17β-reduction by Priestia aryabhattai [0.03%]
微生物甾体生物转化：Priestia aryabhattai进行的区域和立体选择性17β-还原
Yogeswari Sudhakar,Reddy Krishna Manasa,Dhanapal Priyadarshini et al.
Yogeswari Sudhakar et al.
The conversion of 17-oxosteroids to 17β-hydroxysteroids stands as a pivotal process in the synthesis of numerous steroidal drugs and intermediates. This study explored the potential of the strain Priestia aryabhattai (IICT-BC-1279) to cata...
Target-specific high-throughput screening of anti-inflammatory phytosteroids for autoimmune diseases: A molecular docking-dynamics simulation approach [0.03%]
针对自身免疫疾病的抗炎植物甾醇的特异性高通量筛选：分子对接动力学模拟方法
Alaka Sahoo,Sudhir Kumar Paidesetty,Maitreyee Panda
Alaka Sahoo
Without proper pathophysiology and recommended therapy, synthetic steroids are widely used as a first-line option for the management of autoimmune diseases. However, their prolonged use often leads to severe side effects such as osteoporosi...
Isoxazolyl steroid blocks the Shh signaling pathway and the expression of MMP-2 and MMP-9 in cervical carcinoma cell lines [0.03%]
异噁唑基类固醇阻断Shh信号通路以及在宫颈癌细胞系中MMP-2和MMP-9的表达
Olga Timoshenko,Elena Kugaevskaya,Tatiana Gureeva et al.
Olga Timoshenko et al.
Cervical cancer is the fourth leading cause of cancer death among women worldwide. Matrix metalloproteinases MMP-2 and MMP-9 play a leading role in the processes of invasion and metastasis in cervical cancer. Research on the development of ...
Stereo- and regioselectivity in nitrile oxide cycloaddition reactions to norethisterone acetate as dipolarophile [0.03%]
硝基氧化物与norethisterone 醋酸酯作为偶极子加成反应中的立体和区域选择性
Giuseppe Faita,Mariella Mella,Paolo Quadrelli
Giuseppe Faita
Benzo- and anthracenenitrile oxides undergo 1,3-dipolar cycloaddition reactions with 17 α- acetate norethisterone affording the expected isoxazoline and isoxazoles derivatives in good yields and as single regioisomers. The structures of al...