Ursane hybrids with 5-amino-1,2,3,4-thiatriazole, 1-tetrazole-5-thione, and 1-tetrazole-5-amines and study of their inhibition of main SARS-CoV-2 protease [0.03%]
具有5-氨基-1,2,3,4-噻三氮唑、1-四氮唑-5-硫烷和1-四氮唑-5-胺基的ursane杂化物及其对主要SARS-CoV-2蛋白酶抑制的研究
Sergey A Popov,Elvira E Shults,Dmitry S Baev et al.
Sergey A Popov et al.
A series of new heterocyclic ursane and 28-norursane hybrids - derivatives of 5-amino-1,2,3,4-thiatriazole, 1-tetrazole-5-thione, and 1-tetrazole-5-amines were prepared. Reacting triterpenoids holding NCS groups at different distances from ...
New secondary metabolites from the soil-derived Aspergillus versicolor QC812 [0.03%]
来源于土生曲霉QC812的新次级代谢产物
Jiacheng Weng,Siqi Li,Runchao Ma et al.
Jiacheng Weng et al.
A new 18,22-cyclosterol, aspersteroline A (1), and a new DMOA-derived meroterpenoid, asperterpene O (2), along with three known compounds (3 - 5), namely mer-NF8054X (3), terretonin D (4), and asperterpene J (5), were isolated from the soil...
Sarcococca species: A source of bioactive steroidal alkaloids - A review [0.03%]
沙田木属植物生物活性甾体生物碱研究进展
Nguyen Manh Ha,Ninh The Son
Nguyen Manh Ha
Background: Sarcococca species (the family Buxaceae), containing a large number of steroidal alkaloids, were often used as medicinal plants for treating various ailments, such as fever, pain, and inflammation. ...
In silico analysis of Moringaceae derived potential drug-like compounds against Newcastle disease virus [0.03%]
模拟分析毛菍属潜在药物活性化合物对抗新城疫病毒的效果
Muhammad Hammad Mustafa,Fayyaz-Ur Rehman,Muhammad Ali et al.
Muhammad Hammad Mustafa et al.
Newcastle disease virus (NDV) classified in the Avian avulavirus 1 [genus Orthoavulavirus, subfamily Avulavirinae, family Paramyxoviridae] constitutes a serious financial risk to the global poultry market. Available vaccines do not show goo...
Peter Langer
Peter Langer
Palladium catalyzed cross-coupling reactions of estrone allow for the synthesis of a variety of substituted steroids which are not readily available by other methods. Products include various alkynylated and arylated estrones and 13α-estro...
Steroid sulfatase and the transporter of sulfated steroids are upregulated in granulose cells from women of POSEIDON group 4 in controlled ovarian hyperstimulation for in vitro fertilization cycles [0.03%]
甾体硫酸盐和硫酸化甾体的转运蛋白在控制卵巢过度刺激以进行体外受精周期中来自POSEIDON组4的颗粒细胞中高表达
Karina Sequeira,Soledad Henriquez,Paulina Kohen et al.
Karina Sequeira et al.
Purpose: The reduced circulating levels of dehydroepiandrosterone sulphate (DHEA-S) are associated with women with poor ovarian response, > 35 years old and low ovarian reserve (POSEIDON group 4, PG4) in cycles of control...
Effect of dexamethasone on biological properties and metabolic adaptations of normal prostate epithelial cells under mild serum conditions [0.03%]
地塞米松对轻度血清条件下正常前列腺上皮细胞生物学特性及代谢适应性的影响
Weronika Broszkiewicz,Jakub Beda,Kamila Domińska
Weronika Broszkiewicz
Limiting serum concentration in culture medium constitutes an environmental stress that disrupts cellular homeostasis and activates adaptive metabolism. This study aims to examine the impact of dexamethasone (DEX) on biological properties (...
Dehydroepiandrosterone sulphate (DHEAS) supplementation impacts adrenal cortex morphophysiology of aged female gerbils [0.03%]
脱氢表雄酮硫酸盐(DHEAS)补充影响雌性衰老仓鼠肾上腺皮质形态生理学
Carolina Marques Bedolo,Isabella Carolina Cozim,Vitor Grigio et al.
Carolina Marques Bedolo et al.
During the process of aging, it is common for women to take dehydroepiandrosterone sulphate (DHEAS) supplements to prevent adrenopause. However, the potential effects of this supplementation on the adrenal cortex have not yet been fully elu...
Mendelian randomization studies of testosterone exposure: A systematic review [0.03%]
睾酮暴露的孟德尔随机化研究：系统性综述
Annika Magdalena Rhomberg-Kauert,Morten Tulstrup,Christoffer Badsted et al.
Annika Magdalena Rhomberg-Kauert et al.
Background: Testosterone impacts reproductive health, cardiovascular function, and metabolism. Considering the use of testosterone therapy and anabolic steroid misuse, understanding its health effects is important. While ...
Synthesis, NMR and X-ray characterization of dibenzoannulated dimeric steroid spiroketals. evaluation of cytotoxicity and anti-inflammatory activity [0.03%]
二聚类固醇螺酮的合成、核磁及单晶解析和抗肿瘤活性筛选及抗炎活性评价研究
Rsuini U Gutiérrez-Aguilar,Juan A Antolín-González,Nimsi Campos-Xolalpa et al.
Rsuini U Gutiérrez-Aguilar et al.
Two dibenzoannulated dimeric steroid spiroketals were obtained from cholesterol and 1,4-phenylenedimethanol. The key step in synthetic protocol is a Pd-catalyzed double spiroketalization in an adduct obtained from the double Sonogashira cou...