Steroidal scaffold dichotomy: pathogenic role of 7-ketocholesterol versus protective FXR-antagonistic actions of guggulsterone in metabolic regulation [0.03%]
甾体支架二分法：7-酮基胆固醇的致病作用与uggulosterone的FXR拮抗保护作用在代谢调节中的作用
Sarvesh Sabarathinam,Nila Ganamurali
Sarvesh Sabarathinam
Obesity-associated Dyslipidemia and inflammation are aggravated by the accumulation of toxic oxysterols, particularly 7-ketocholesterol (7-KC), which amplifies oxidative stress and metabolic dysfunction. The steroidal scaffold is a central ...
Duration of vitamin D supplementation modulates the association between cardiovascular disease and high-sensitivity C-reactive protein across body mass index strata [0.03%]
维生素D补充时长通过BMI分层调节心血管疾病与高敏C反应蛋白的关系
Theocharis Koufakis,Theofylaktos Georgiadis,Areti Kourti et al.
Theocharis Koufakis et al.
Background: Cardiovascular disease (CVD) and higher body mass index (BMI) are linked to chronic low-grade inflammation. It is unclear whether vitamin D modifies the association between CVD and inflammatory biomarkers unif...
Design, synthesis and characterization of novel cholesterol derivatives: Anti-cancer activity, ADMET profiling and DFT insights [0.03%]
新型胆固醇衍生物的设计、合成与表征：抗肿瘤活性、ADMET评价及DFT研究见解
Anmol Verma,Poonam Rawat,Sanyukta Shukla et al.
Anmol Verma et al.
In the present work, Steglich esterification and Mizoroki-Heck reaction have been carried out for the synthesis of novel cholesterol derivatives. The synthesized derivatives 2, 3, 4, 5 and 6 were purified through column chromatography and c...
Mineralocorticoid receptor antagonism of vamorolone: Evidence from LIONHEART and VISION-DMD clinical trials [0.03%]
来自LIONHEART和VISION-DMD临床试验的矿皮质激素受体拮抗剂作用证据:vamorolone的研究
Ana de Vera,Paula R Clemens,Utkarsh J Dang et al.
Ana de Vera et al.
The effect of vamorolone, the first dissociative corticosteroid for Duchenne muscular dystrophy (DMD), at the mineralocorticoid receptor (MR) was investigated in the Phase 1 mechanistic LIONHEART study and using serum samples from boys with...
Quercetin-cyclodextrin combination effects on cytochrome P450 genes, oxidative stress and ovarian function in PCOS rats [0.03%]
檞皮素-环糊精结合物对PCOS大鼠CYP450基因、氧化应激和卵巢功能的影响
Fatemeh Taghipour,Hadi Samadian,Razieh Dalirfardouei et al.
Fatemeh Taghipour et al.
This study investigates the effect of the quercetin/cyclodextrin (Que/β-CD) complex on oxidative stress, cytochrome P450 gene expression, and ovarian tissue structure in a rat polycystic ovary syndrome (PCOS) model. The Que/β-CD complexes...
Synthesis and preliminary biological evaluation of novel steroidal compounds as antibacterial agents [0.03%]
新型甾体化合物的合成及其抗菌活性初步评价
Anna Esposito,Maria Stabile,Antonella Migliaccio et al.
Anna Esposito et al.
Antimicrobial resistance is currently one of the most serious and alarming threats to human health; therefore, the identification of novel antimicrobial agents is a compelling need. Recently, we identified the heterocyclic steroid PYED-1 as...
Vitamin D potentiation of metformin hepatoprotective activities: Concurrent targeting of carbohydrate enzymatic pathways and PCSK9/AGEs-regulated oxidative stress mechanisms in type 2 diabetic male Wistar rats [0.03%]
维生素D增强二甲双胍在2型糖尿病大鼠中的护肝作用：同时靶向糖类酶促途径和PCSK9 / AGEs调节的氧化应激机制
Halimat Amin Abdulrahim,Adeyemi Fatai Odetayo,Muhammad Bashir Amosa et al.
Halimat Amin Abdulrahim et al.
Background: Emerging evidence indicates that metformin-based combination therapy may offer better glycemic control and improved tolerability compared to diabetes monotherapy. Building on this, vitamin D was considered a p...
Are dexamethasone implants a safe and effective breakthrough in uveitis treatment? A systematic review and meta-analysis [0.03%]
玻璃体内注射德宝松治疗葡萄膜炎的系统评价和meta分析
Kai-Yang Chen,Hoi-Chun Chan,Chi-Ming Chan
Kai-Yang Chen
Background: Uveitis encompasses inflammatory conditions affecting the iris, ciliary body, and choroid. Its management relied on corticosteroids, immunosuppressive agents, and, more recently, biologic therapies. The develo...
Salivary 1,25(OH)2D3 & cortisol as biomarkers of anxiety, depression, and periodontitis: a comparative cross-sectional study [0.03%]
唾液1,25(OH)2D3和皮质醇作为牙周炎、焦虑和抑郁生物标志物的比较性横断面研究
Sara Rafique,Sadaf Ahmed,Shamoon Noushad
Sara Rafique
Purpose: This study examines the correlation between salivary levels of 1,25(OH)2D3 (calcitriol) and cortisol in healthy individuals and patients with anxiety and depression, both with and without periodontitis. The innov...
Biotransformation of 22-hydroxy-23,24-bisnorchol-4-ene-3-one by Gibberella fujikuroi CICC 40272-A to discover novel C22 steroid derivatives [0.03%]
柄锈菌CICC 40272-A转化22-羟基-23,24-并四氢诺-4-烯-3-酮发现新型C22甾体类衍生物
Ran He,Wan Cui,Ming Song et al.
Ran He et al.
The microbial transformation of steroids offers a sustainable and selective approach to synthesize pharmacologically valuable derivatives. This study investigated the biotransformation of 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC) by G...