An efficient regioconvergent synthesis of 3-aza-obeticholic acid [0.03%]
一种高效的3-氮杂-OBDA的区域选择性收敛式合成方法
Lawrence D Harris,Roselis A Landaeta Aponte,Wanting Jiao et al.
Lawrence D Harris et al.
Bile acids (BAs) are steroidal molecules that play important roles in nutrient absorption, distribution, and excretion. They also act on specific receptors implicated in various metabolic and inflammatory diseases demonstrating their import...
Evaluation of structural features of anabolic-androgenic steroids: entanglement for organ-specific toxicity [0.03%]
雄激素类药物的结构特征评价：器官特异性毒性及其相互作用
Ankan Sinha,Vishal Kumar Deb,Abhijit Datta et al.
Ankan Sinha et al.
Anabolic-androgenic steroids (AASs), more correctly termed "steroidal androgens", are a broad category of compounds including both synthetic derivatives and endogenously produced androgens like testosterone, which have long been employed as...
SPRY4 regulates ERK1/2 phosphorylation to affect oxidative stress and steroidogenesis in polycystic ovary syndrome [0.03%]
SPRY4通过调节ERK1/2磷酸化来影响多囊卵巢综合征氧化应激和类固醇生成
Yu Pan,Chunxia Yang,Yan Sun et al.
Yu Pan et al.
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of childbearing age. The role of Sprouty RTK Signaling Antagonist 4 (SPRY4) in ovarian function in PCOS was investigated herein, focusing on its regulation of ERK1/...
Palladium catalysed cross coupling reactions on 2,3-isoxazol-17α-ethynyltestosterone, their anti-cancer activity, molecular docking studies and ADMET analysis [0.03%]
钯催化的2,3-异噁唑-17α-乙炔基睾丸素交叉偶联反应，其抗肿瘤活性及分子对接和ADMET分析研究
Astha Yadav,Anmol Verma,Saurabh Kumar Singh et al.
Astha Yadav et al.
In the current study, the Sonogashira coupling reaction of danazol with aryl halides was carried out, yielding new aryl substituted danazol derivatives. The synthetic compounds were examined for anti-cancer potential on the HeLa human cervi...
Investigating the influence of estrous cycle-dependent hormonal changes on neurogenesis in adult mice [0.03%]
探讨雌鼠动情周期依赖性激素变化对成年神经新生的影响
Leila Mirzaeian,Khadijeh Bahrehbar,Mandana Emamdoust et al.
Leila Mirzaeian et al.
Objective: Neurogenesis is the process of generating new neurons from neural stem cells (NSCs) in the adult brain. Sex hormones play an essential role in the development of the brain. The aim of this study was to evaluate...
Neurotoxic mechanisms of dexamethasone in SH-SY5Y neuroblastoma cells: Insights into bioenergetics, oxidative stress, and apoptosis [0.03%]
地塞米松对神经细胞的神经毒性机制：关于生物能量学，氧化应激及凋亡的新见解
Ekramy M Elmorsy,Ayat B Al-Ghafari,Huda A Al Doghaither et al.
Ekramy M Elmorsy et al.
Despite the known therapeutic uses of dexamethasone (DEX), the specific mechanisms underlying its neurotoxic effects in neuronal cells, particularly in undifferentiated human neuroblastoma (SH-SY5Y) cells, remain inadequately understood. Th...
Ergostanes from the mushroom Trametes versicolor and their cancer cell inhibition: In vitro and in silico evaluation [0.03%]
从菌类Trametes versicolor中分离出的植物固醇及其体内外抗肿瘤活性研究
Alice W Njue,Josiah Omolo,Ryan S Ramos et al.
Alice W Njue et al.
In this study, five steroid compounds were isolated from the fruiting bodies mushroom Trametes versicolor. The compounds, 9,19-cyclolanostane-3,29-diol (3), ergosta-7,22-dien-3-acetate (4), and ergosta-8(14),22-dien-3β,5α,6β,7α-tetrol (...
A review of metabolic and microbial influences on women with polycystic ovarian syndrome [0.03%]
代谢和微生物因素对多囊卵巢综合症女性的影响综述
Foram K Ravat,Janki R Goswami,Sneha M Nair et al.
Foram K Ravat et al.
Introduction: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine and metabolic disorder affecting reproductive-aged women worldwide. Characterized by irregular menstruation, signs of hyperandrogenism, polycystic ov...
The interpretation of immunometric, chromatographic and mass spectrometric data for steroids in diagnosis of endocrine disorders [0.03%]
免疫测定、色谱和质谱数据在内分泌疾病类固醇诊断中的解读
John W Honour
John W Honour
The analysis of steroids for endocrine disorders is in transition from immunoassay of individual steroids to more specific chromatographic and mass spectrometric methods with simultaneous determination of several steroids. Gas chromatograph...
Structural perspectives on the androgen receptor, the elusive shape-shifter [0.03%]
雄激素受体的结构观点：“难以捉摸”的变形者
Madisyn J Johnson,Elizabeth V Wasmuth
Madisyn J Johnson
The androgen receptor (AR) is a type I nuclear receptor and master transcription factor responsible for development and maintenance of male secondary sex characteristics. Aberrant AR activity is associated with numerous diseases, including ...