Ascorbic acid Mitigates behavioural disturbances associated with letrozole-induced PCOS via switching-off JAK2/STAT5 and JAK2/ERK1/2 pathways in rat hippocampus [0.03%]
维生素C通过关闭JAK2/STAT5和JAK2/ERK1/2信号通路来减轻来曲唑诱导的PCOS大鼠海马行为异常及相关机制研究
Muhammed A Saad,Alyasaa A Rastanawi,Ayman E El-Sahar et al.
Muhammed A Saad et al.
Purpose: Polycystic ovary syndrome (PCOS) is an endocrine disorder with the highest prevalence among other disorders in sexually-active women. It is associated with broad-spectrum hormonal and metabolic disturbances with ...
Patterns of corticosterone exposure affect the subcellular localisation of mineralocorticoid and glucocorticoid receptor complexes and gene expression [0.03%]
皮质酮暴露模式影响盐皮质激素和糖皮质激素受体复合物的亚细胞定位及基因表达
Susana N Paul,Anna De Visser,Federica Motta et al.
Susana N Paul et al.
Mineralocorticoid (MR) and glucocorticoid receptors (GR) act as transcription factors and major mediators of glucocorticoid signalling, with pivotal roles in regulating the stress response and hormonal signalling, mood, cognition and memory...
Sonogashira coupling-based synthesis and in vitro cytotoxic evaluation of C-2 alkynyl derivatives of withaferin A [0.03%]
与withaferin A具有C-2炔基取代衍生物的Sonoagashi偶联基合成及体外细胞毒性评价
Shabir Ahmad Mir,Sameera Firdous,Mir Shahid Maqbool et al.
Shabir Ahmad Mir et al.
Testosterone replacement has a beneficial effect on the hemostatic system by altered gene expression of coagulation factors [0.03%]
睾酮替代通过凝血因子基因表达的改变对止血系统产生有益影响
Jafar Vatandoost,Amirreza Yaghoubi-Nezhad,Amir Masoud Sadr et al.
Jafar Vatandoost et al.
This study aimed to investigate the effects of testosterone replacement therapy on hemostasis and some procoagulant gene expression in mice. 42 mice were randomly divided into two groups of non-orchiectomized (non-ORX) and orchiectomized (O...
Synthesis of 13β- and 13α-epimers of 3-hydroxy-17-hydroxymethylestra-1,3,5(10)-triene and considerations on their hormonal and antiproliferative potency [0.03%]
3-羟基-17-羟甲基雌甾-1，3，5（10）-三烯的13β-和13α-差向异构体合成及其激素作用与抗增殖活性研究
Yu V Kuznetsov,M O Tserfas,A M Scherbakov et al.
Yu V Kuznetsov et al.
Starting from 3-methoxyestra-1,3,5(10),16-tetraene-17-carbaldehydes of natural (13β) and epimeric (13α) series, a series of isomeric 3-hydroxy-17-hydroxymethylestra-1,3,5(10)-trienes, including those containing 16α,17α-annulated cyclopr...
Assessment of anti-cancer evaluation of new metabolites isolated from baked Sarcosphaera crassa: An edible poisonous mushroom [0.03%]
评估来自可食用毒蘑菇烤制的Sarcosphaera crassa中的新次生代代谢产物的抗癌活性
Zain Ullah,Mehmet Öztürk
Zain Ullah
The growing demand for wild mushrooms as functional foods has increased due to their pharmacological significance. Sarcosphaera crassa is a deadly poisonous mushroom consumed by people living in northern and eastern Europe after being cooke...
Invalidating betulinic acid as a potential inhibitor against the main protease of SARS-CoV-2 via combined approaches [0.03%]
通过联合方法验证熊果酸不是SARS-CoV-2主要蛋白酶的潜在抑制剂
Jiankai Ye,Tao Xu,Rui Zhang et al.
Jiankai Ye et al.
In contrast to an earlier study reporting that betulinic acid is an inhibitor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), we demonstrated that beutilinic acid is not a potential Mpro inhibitor v...
Expression of pregnenolone-synthesizing enzymes CYP11A1 and CYP1B1 in the human, rat, and mouse brain [0.03%]
人、大鼠和小鼠脑中孕烯醇酮合成酶CYP11A1和CYP1B1的表达
Yiqi Christina Lin,Vassilios Papadopoulos
Yiqi Christina Lin
The central nervous system (CNS) is capable of synthesizing steroids for modulating essential functions such as neurotransmission, neuroplasticity, and neuroinflammation. These locally synthesized steroids, called neurosteroids, are produce...
Current advances in phytosterol free forms and esters: Classification, biosynthesis, chemistry, and detection [0.03%]
植物甾醇自由形式和酯的当前进展：分类、生物合成、化学及检测方法学
Farid Khallouki,Wafa Zennouhi,Lhoussain Hajji et al.
Farid Khallouki et al.
Phytosterols are plant sterols that are important secondary plant metabolites with significant pharmacological properties. Their presence in the plant kingdom concerns many unrelated botanical families such as oleageneous plants and cereals...
A sustainable approach towards extraction of diosgenin from fenugreek seeds using polystyrene/divinyl benzene resin [0.03%]
一种从香auge籽中提取大豆苷素的可持续方法：使用聚苯乙烯/二乙烯基树脂
Sharavan Kumar,B M Praveen,Aralihalli Sudhakara
Sharavan Kumar
Diosgenin, a bioactive molecule; is one of the deeply explored saponin with a wide spectrum of benefits against various ailments. The extraction and yield enhancement of diosgenin from a wide range of naturally occurring medicinal products ...