Martin Litzenburger,Rita Bernhardt
Martin Litzenburger
Steroids and their oxyfunctionalized counterparts are valuable compounds for the pharmaceutical industry; however, the regio- and stereoselective introduction of oxygen is a challenging task for the synthetic chemistry. Thus, cytochromes P4...
Hydroxylative activity of Aspergillus niger towards androst-4-ene and androst-5-ene steroids [0.03%]
赭曲霉对雄甾-4-烯和雄甾-5-烯类固醇的羟化作用
Alina Świzdor,Anna Panek,Natalia Milecka-Tronina
Alina Świzdor
Aspergillus niger, one of fungal species most frequently used for experimental and industrial-scale biotransformations of various organic compounds, is generally known to transform steroids at 16β position. In this work, application of the...
Solvent-free synthesis of 6β-phenylamino-cholestan-3β,5α-diol and (25R)-6β-phenylaminospirostan-3β,5α-diol as potential antiproliferative agents [0.03%]
作为潜在抗增殖剂的6β-苯氨基胆甾烷-3β，5α-二醇和（25r）-6β-苯基氨基螺[5.5]十一碳-3β，5α-二醇的无溶剂合成法
Delia Soto-Castro,Roberto Carlos Lara Contreras,Maria Del Socorro Pina-Canseco et al.
Delia Soto-Castro et al.
In this paper is described a synthetic route to 6β-phenylamino-cholestan-3β,5α-diol and (25R)-6β-phenylaminospirostan-3β,5α-diol, starting from cholesterol and diosgenin, respectively. The products were obtained in two steps by epoxid...
Francisca Plaza-Parrochia,Carmen Romero,Luis Valladares et al.
Francisca Plaza-Parrochia et al.
Normal endometrial function requires of cell proliferation and differentiation; therefore, disturbances in these processes could lead to pathological entities such as hyperplasia and endometrial adenocarcinoma, where cell proliferation is i...
β-Estradiol-3-benzoate confers neuroprotection in Parkinson MPP+ rat model through inhibition of lipid peroxidation [0.03%]
倍半油酸甘油脂棓酸酯通过抑制脂质过氧化反应对帕金森病MPP+大鼠模型的神经保护作用
Yoshajandith Aguirre-Vidal,Antonio Monroy-Noyola,Laura Anaya-Ramos et al.
Yoshajandith Aguirre-Vidal et al.
Estradiol (E2), in addition to its known hormone function, is a neuroactive steroid that has shown neuroprotective profile in several models of neurological diseases. The present study explores the antioxidant effect of β-estradiol-3-benzo...
Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD+-dependent SIRT1 [0.03%]
褪黑素通过NAD +依赖性SIRT1保护糖皮质激素诱导的软骨细胞损伤
Wei Yang,Xiaomin Kang,Na Qin et al.
Wei Yang et al.
Intra-articular injection of glucocorticoids is used to relieve pain and inflammation in osteoarthritis patients, which is occasionally accompanied with the serious side effects of glucocorticoids in collagen-producing tissue. Melatonin is ...
Investigation of pH and substituent effects on the distribution ratio of novel steroidal ring D- and A-fused arylpyrazole regioisomers and evaluation of their cell-growth inhibitory effects in vitro [0.03%]
新型甾族环D和A芳基吡唑异构体分配比率的pH及取代基效应研究及其体外细胞增殖抑制作用评价
Ádám Baji,Ferenc Kovács,Gergő Mótyán et al.
Ádám Baji et al.
Novel androstanopyrazoles have been efficiently synthesized from steroidal β-ketoaldehydes with different arylhydrazine hydrochlorides both under acidic and basic conditions. Knorr-type transformations of 16-hydroxymethylene-dehydroepiandr...
20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats [0.03%]
20-羟基蜕皮酮对自发性高血压大鼠心脏重塑的改善作用
Sukanya Phungphong,Anusak Kijtawornrat,Sirinut Chaiduang et al.
Sukanya Phungphong et al.
Background: Ecdysteroids, a group of steroid hormones found in insects and many plants, have been shown to prevent various changes in mammalian tissues after female sex hormone deprivation. ...
The effect of newly synthesized progesterone derivatives on apoptotic and angiogenic pathway in MCF-7 breast cancer cells [0.03%]
新型孕酮衍生物对MCF-7乳腺癌细胞凋亡和血管生成途径的影响
Shaymaa M M Yahya,Abdou O Abdelhamid,Mervat M Abd-Elhalim et al.
Shaymaa M M Yahya et al.
Due to its high potency and selectivity, anticancer agents consisting of combined molecules have gained great interests. The current study introduces newly synthesized progesterone derivatives of promising anticancer effect. Moreover, the p...
Synthesis and bioactivity of bis-steroidal pyrazine 23-deoxy-25-epi ritterostatin GN1N [0.03%]
23-脱氧-25-环氧里特索丁并茋类双甾体吡嗪衍生物的合成及活性研究
Rayala Naveen Kumar,Seongmin Lee
Rayala Naveen Kumar
Cephalostatins, ritterazines and their hybrid bis-steroidal pyrazine analogs such as 25-epi-rittereostatin GN1N show unusually high potency against a wide range of cancer cell lines. Herein, we report the synthesis and bioactivity of 23-deo...