Synthesis of novel α-spinasterol derivatives and their inhibitory effects on CCL17 and CCL22 chemokine expression [0.03%]
新型α-spinasterol衍生物的合成及其对CCL17和CCL22趋化因子表达的影响研究
Hyejin Moon,Hongjoon Yoon,Hana Jung et al.
Hyejin Moon et al.
Natural α-spinasterol is well known for its various biological activities. In this study, we investigated the anti-inflammatory effects of newly synthesized α-spinasterol derivatives by tracking the expression of CCL17 and CCL22 chemokine...
Understanding the role of hormones in pediatric growth: Insights from a double-debiased machine learning approach [0.03%]
儿童生长激素作用的双校正机器学习方法研究
Ying Deng,Ning Yang,Jun Wang et al.
Ying Deng et al.
This study investigates the causal relationships between hormone levels and growth and development of children, focusing specifically on height disparities in cases of dwarfism. Besides utilizing double-debiased machine learning approach, t...
Fraydoon Rastinejad
Fraydoon Rastinejad
Nuclear receptors (NRs) regulate gene expression in response to hormonal signals, influencing diverse physiological processes and diseases. Structural and dynamics investigations based on X-ray crystallography, cryo-electron microscopy (cry...
Extraction of diosgenin using different techniques from fenugreek seeds- A review [0.03%]
从香蒲种子中使用不同的技术提取大豆苷素- 一次回顾性研究
Sharavan Kumar,B M Praveen,Aralihalli Sudhakara et al.
Sharavan Kumar et al.
Diosgenin, falls under the category of steroidal saponin present in fenugreek seeds (Trigonella foenum-graecum) in the amount of 0.2-09%. This compound possesses certain pharmacological characteristics like anti-inflammatory, anti-cancer, a...
Relative fat mass (RFM) is linked to testosterone deficiency in adult males [0.03%]
相对体脂百分比与成年男性睾酮缺乏有关
Menghuan Wu,Zhaoxiang Wang
Menghuan Wu
Purpose: Relative fat mass (RFM) is a novel obesity assessment metric, and we aim to explore the relationship between RFM and testosterone deficiency in US adult males. ...
Cardioprotective effects of S-equol, a soybean metabolite with estrogen activity, and role of the PI3K/Akt pathway in a male rat model of ischemic reperfusion [0.03%]
雌激素活性大豆代谢产物S- equol的心肌保护作用及其在雄性大鼠缺血再灌注模型中PI3K／Akt信号转导通路的作用机制
Mariko Yamada,Yosuke Nakadate,Keisuke Omiya et al.
Mariko Yamada et al.
Purpose: S-equol, an isoflavone metabolite with high estrogenic activity, exhibits organ-protective effects via the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. While estrogen has cardiopro...
PTX3 impairs granulosa cell function by promoting the secretion of inflammatory cytokines in M1 macrophages via the JAK pathway [0.03%]
PTX3通过JAK途径促进M1巨噬细胞分泌炎症性细胞因子从而损害颗粒细胞功能
Ying Chen,Xiaofang Luo,Yizhe Li et al.
Ying Chen et al.
Polycystic Ovary Syndrome (PCOS) is an endocrine disorder syndrome among women in their reproductive years and is often linked to chronic inflammation. Pentraxin 3 (PTX3), a member of the pentraxin protein family, plays a key role in inflam...
Comparison of a chemiluminescence immunoassay with LC-MS/MS in the determination of the plasma aldosterone concentration in patients with impaired renal function [0.03%]
化学发光免疫测定与液相色谱串联质谱法测定肾功能不全患者的血浆醛固酮浓度的比较
Qiurong Zeng,Junlong Li,Yi Yang et al.
Qiurong Zeng et al.
Purpose: Compared with chemiluminescence immunoassay (CLIA), the quantification of the plasma aldosterone concentration (PAC) via liquid chromatography-tandem mass spectrometry (LC-MS/MS) yields lower values. The extent t...
Comparative Study
Steroids. 2025 Jan:213:109540. DOI:10.1016/j.steroids.2024.109540 2025
Unraveling the impact of semaglutide in a diabetic rat model of testicular dysfunction: Insights into spermatogenesis pathways and miRNA-148a-5p [0.03%]
司美格鲁肽对糖尿病小鼠睾丸功能障碍影响的机制研究及其对miRNA-148a-5p和 spermatogenesis 路径的影响探究
Basel A Abdel-Wahab,Ehab A M El-Shoura,Mohammed S Habeeb et al.
Basel A Abdel-Wahab et al.
Background: Diabetes has been a long-known risk factor for male sexual dysfunction, which may be caused by persistent hyperglycemia, oxidative stress, and spermatogenesis inhibition. This study explored the potential of S...
Recent advances in the development of 17beta-hydroxysteroid dehydrogenase inhibitors [0.03%]
17β-羟基类固醇脱氢酶抑制剂的研究进展
Donald Poirier
Donald Poirier
The family of 17β-hydroxysteroid dehydrogenases (17β-HSDs) occupies a prominent place due to its number of isoforms, which carry out a bidirectional transformation (reduction of a steroid carbonyl to alcohol and oxidation of a steroid alc...