Recent trends in interorganizational deal networks in pharmaceutical and biotechnology industries [0.03%]
制药和生物技术行业中组织间交易网络的最新趋势
Kentaro Yashiro,Yeongjoo Lim,Shintaro Sengoku et al.
Kentaro Yashiro et al.
While there have been trends in drug discovery from small molecules to new chemical modalities since the large mergers and acquisitions (M&A) of pharmaceutical companies in the late 2000s, trends in interorganizational deal networks have no...
Gene and cell therapy approaches for familial hypercholesterolemia: An update [0.03%]
家族性高胆固醇血症的基因和细胞治疗方案：最新进展
Negin Parsamanesh,Omid Kooshkaki,Haleh Siami et al.
Negin Parsamanesh et al.
Familial hypercholesterolemia (FH) is a common autosomal codominant hereditary illness marked by the heightened risk of early atherosclerotic cardiovascular disease and high blood levels of low-density lipoprotein cholesterol (LDL-C). FH pa...
Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer [0.03%]
线粒体靶向型纳米颗粒：癌症中的传递和治疗剂
Chaithanya Ganji,Veda Muppala,Musaab Khan et al.
Chaithanya Ganji et al.
Mitochondria are the powerhouses of cells and modulate the essential metabolic functions required for cellular survival. Various mitochondrial pathways, such as oxidative phosphorylation or production of reactive oxygen species (ROS) are dy...
Brain-derived neurotrophic factor (BDNF) in perinatal depression: Side show or pivotal factor? [0.03%]
脑源性神经营养因子(BDNF)在围产期抑郁症中的作用：从属角色还是关键因素？
Saumya Singh,Katarine Fereshetyan,Susan Shorter et al.
Saumya Singh et al.
Perinatal depression is the most common psychiatric complication of pregnancy, with its detrimental effects on maternal and infant health widely underrated. There is a pressing need for specific molecular biomarkers, with pregnancy-related ...
Dang Ding,Shujing Xu,Edeildo Ferreira da Silva-Júnior et al.
Dang Ding et al.
The (re)emergence of multidrug-resistant viruses and the emergence of new viruses highlight the urgent and ongoing need for new antiviral agents. The use of peptidomimetics as therapeutic drugs has often been associated with advantages, suc...
Promising novel therapeutic targets for kidney disease: Emphasis on kidney-specific proteins [0.03%]
肾脏病的新型治疗靶点：着重于肾脏特异性蛋白
Tathambika Tejeswini Sen,Ajinath Kale,Maciej Lech et al.
Tathambika Tejeswini Sen et al.
Worldwide, around 850 million people are diagnosed with kidney disease but the available treatment options are still limited. Preclinical studies propose a plethora of druggable targets that can attenuate kidney disease and could qualify as...
Komal Sharma,Krishna K Sharma,Anku Sharma et al.
Komal Sharma et al.
The progressive development of peptides from reaction vessels to life-saving drugs via rigorous preclinical and clinical assessments is fascinating. Peptide therapeutics have gained momentum with the evolution of techniques in peptide chemi...
Insight into the pivotal role of signaling pathways in psoriasis pathogenesis, potential therapeutic molecules and drug delivery approaches [0.03%]
信号通路在牛皮癣发病机制中发挥核心作用的见解，潜在的治疗分子和药物传递方法
Yashika Tomar,Srividya Gorantla,Gautam Singhvi
Yashika Tomar
Psoriasis is a multifactorial chronic autoimmune skin disorder, the exact cause of which is still under investigation. It is classified into different types displaying various histopathological features such as hyperproliferation, irregular...
Polyester-based long acting injectables: Advancements in molecular dynamics simulation and technological insights [0.03%]
基于聚酯的长效注射剂：分子动力学模拟和技术见解的进步
Niranjan G Kotla,Abhijeet Pandey,Y Vijaya Kumar et al.
Niranjan G Kotla et al.
Long-acting injectable (LAI) delivery technologies have enabled the development of several pharmaceutical products that improve patient health by delivering therapeutics from weeks to months. Over the last decade, due to its good biocompati...
Immunoconjugates and bispecific antibodies: Trends in therapeutic success and commercial focus [0.03%]
免疫 conjugates和双特异性抗体：治疗成功和商业关注的趋势
Michael S Kinch,Zachary Kraft,Tyler Schwartz
Michael S Kinch
Monoclonal antibodies (mAbs) have revolutionized the selective targeting of disease, as well as changing the character of the pharmaceutical industry. Although most attention has focused on conventional antibodies, immunoconjugates and bisp...