Role of transcription termination factor Rho in anti-tuberculosis drug discovery [0.03%]
转录终止因子Rho在抗结核药物发现中的作用
Sunil Kumar,Shashikanta Sau,Puja Kumari Agnivesh et al.
Sunil Kumar et al.
Mycobacterial infections, including multidrug and extreme drug-resistant (MDR and XDR) infections, are a severe challenge and create a virtual antibiotic-deficient era. Bacterial transcription is an established antimicrobial drug target. In...
Hyperphosphorylated tau (p-tau) and drug discovery in the context of Alzheimer's disease and related tauopathies [0.03%]
高磷酸化tau（p- tau）与阿尔茨海默病及相关Tau蛋白病的药物发现中的作用
Kendall B E Moore,Ta-Jung Hung,Jessica S Fortin
Kendall B E Moore
Alzheimer's disease (AD) is the most common form of dementia, characterized by intracellular neurofibrillary tangles (NFTs) and extracellular β-amyloid (βA) plaques. No disease-modifying therapy is currently available to prevent the progr...
Marta Pascual-Gilabert,Ruben Artero,Arturo López-Castel
Marta Pascual-Gilabert
The beginning of the 20th decade has witnessed an increase in drug development programs for myotonic dystrophy type 1 (DM1). We have collected nearly 20 candidate drugs with accomplished preclinical and clinical phases, updating our previou...
Rapid progress in neuroimaging technologies fuels central nervous system translational medicine [0.03%]
神经影像技术的快速发展推动中枢神经系统转化医学进步
Linghui Kong,Qian He,Qiu Li et al.
Linghui Kong et al.
Central nervous system (CNS) drug discovery suffers from high attrition rates; translational neuroscience approaches aiming to reduce these high rates include the use of brain imaging technologies. However, there is a need to better underst...
Seng Manivong,Aurélie Cullier,Fabrice Audigié et al.
Seng Manivong et al.
The burden of osteoarthritis (OA), one of the major causes of functional disabilities in humans and animals, continues to increase worldwide while no disease-modifying OA drugs (DMOADs) that either slow down or reverse disease progression h...
Translating precision medicine for autism spectrum disorder: A pressing need [0.03%]
自闭症谱系障碍的精准医疗转化：当务之急
Laura Pérez-Cano,Sara Azidane Chenlo,Rubén Sabido-Vera et al.
Laura Pérez-Cano et al.
Autism spectrum disorder (ASD) is a heterogenous group of neurodevelopmental disorders (NDDs) with a high unmet medical need. Currently, ASD is diagnosed according to behavior-based criteria that overlook clinical and genomic heterogeneity,...
Natural products in pursuing novel therapies of nonalcoholic fatty liver disease and steatohepatitis [0.03%]
天然产物在非酒精性脂肪肝和脂肪性肝炎新疗法中的应用追求
Haiyan Li,Ting Guan,Shi Qin et al.
Haiyan Li et al.
Nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are hepatic manifestations of systemic metabolic dysfunction, which affect one-quarter of the adult population worldwide as estimated, and exhibit high risk in progressing ...
Corrigendum to "Therapeutic potential of fucosyltransferases in cancer and recent development of targeted inhibitors" [Drug Discov. Today 28(1) (2023) 103394] [0.03%]
《对癌症的治疗潜力及靶向抑制剂的最新进展》[Drug Discov. Today 28(1) (2023) 103394]的勘误表
Yixin Lv,Zhoudong Zhang,Sheng Tian et al.
Yixin Lv et al.
Published Erratum
Drug discovery today. 2023 Mar;28(3):103484. DOI:10.1016/j.drudis.2022.103484 2023
Md Asaduzzaman Khan,Mousumi Tania
Md Asaduzzaman Khan
Cordycepin, a nucleoside from Cordyceps mushrooms, has many beneficial properties for health, including anticancer activities. In cancer cells, cordycepin targets various signaling molecules. Here, we review the possible anticancer mechanis...
Intra-articular nanodrug delivery strategies for treating osteoarthritis [0.03%]
用于治疗骨关节炎的关节内纳米药物递送策略
Dongyang Zhou,Fengjin Zhou,Shihao Sheng et al.
Dongyang Zhou et al.
Osteoarthritis (OA) is characterized by progressive cartilage degeneration. Pharmaceutical intervention remains a main treatment approach. However, drug delivery via intra-articular administration (IA) can be restricted by rapid clearance, ...