Decentralised, patient-centric, site-less, virtual, and digital clinical trials? From confusion to consensus [0.03%]
去中心化、以患者为中心、无现场的虚拟和数字化临床试验？从困惑到共识
Yared Santa-Ana-Tellez,Bart Lagerwaard,Amos J de Jong et al.
Yared Santa-Ana-Tellez et al.
There is increasing interest in clinical trials that use technologies and other innovative operational approaches to organise trial activities around trial participants instead of investigator sites. A range of terms has been introduced to ...
Science of, and insights into, thermodynamic principles for dermal formulations [0.03%]
关于皮肤外用药物配制的热力学原理的科学研究及见解
Pronalis Tapfumaneyi,Mohammad Imran,Seyed Ebrahim Alavi et al.
Pronalis Tapfumaneyi et al.
Studies have demonstrated the significant role of the thermodynamic activity of drugs in skin drug delivery. This thermodynamic activity works as a driving force for increasing/improving the absorption of drugs by the skin. It can be change...
Development of JmjC-domain-containing histone demethylase (KDM2-7) inhibitors for cancer therapy [0.03%]
组蛋白去甲基化酶(JmjC domain家族KDM2-7成员)抑制剂的开发作为癌症治疗的新方法
Lan Zhang,Yao Chen,Zhijia Li et al.
Lan Zhang et al.
Histone methylation is the most common histone modification and a highly dynamic regulator of gene transcription. Methylation of lysine residues can alter the structure of chromatin, helping to regulate DNA-based nuclear activities. Lysine ...
Therapeutic potential of targeting IL-17 and its receptor signaling in neuroinflammation [0.03%]
白细胞介素17及其受体信号转导在神经炎症治疗中的潜力
Avtar Singh Gautam,Rakesh Kumar Singh
Avtar Singh Gautam
T helper 17 cells are thought to significantly contribute to the neuroinflammation process during neurogenerative diseases via their signature cytokine, interleukin (IL)-17. Recently, an emerging key role of IL-17 and its receptors has been...
Carmen Cerchia,Antonio Lavecchia
Carmen Cerchia
Over the past decade, the amount of biomedical data available has grown at unprecedented rates. Increased automation technology and larger data volumes have encouraged the use of machine learning (ML) or artificial intelligence (AI) techniq...
Hongyu Li,Qiong Zhang,Qinglan Feng et al.
Hongyu Li et al.
In mammals, N6-methyladenosine (m6A) is thought to be the most common and conserved mRNA modification. Methyltransferase-like 3 (METTL3) is the primary regulator of m6A methyl-transformed modification. Small molecules targeting METTL3 could...
Pharma's Bio-AI revolution [0.03%]
药企的生物AI革命
Isaac Bentwich
Isaac Bentwich
Drug development has become unbearably slow and expensive. A key underlying problem is the clinical prediction challenge: the inability to predict which drug candidates will be safe in the human body and for whom. Recently, a dramatic regul...
Biomimetic cell membrane-coated nanocarriers for targeted siRNA delivery in cancer therapy [0.03%]
仿生细胞膜涂层纳米递送体系在癌症治疗中实现siRNA导向释放研究
Xin Huang,Haoyu Guo,Lutong Wang et al.
Xin Huang et al.
Small interfering RNA (siRNA) therapeutics for cancer are a focus of increasing research interest. However, the major obstacle to their clinical application is the targeted delivery of siRNA to cancer cells at desirable levels. Cell membran...
A FAIR-Decide framework for pharmaceutical R&D: FAIR data cost-benefit assessment [0.03%]
一种面向医药研发的FAIR-Decide框架：制定数据处理规范以实现公平效益评估
Ebtisam Alharbi,Rigina Skeva,Nick Juty et al.
Ebtisam Alharbi et al.
The FAIR (findable, accessible, interoperable and reusable) principles are data management and stewardship guidelines aimed at increasing the effective use of scientific research data. Adherence to these principles in managing data assets i...
Design of lipid-based nanoparticles for delivery of therapeutic nucleic acids [0.03%]
用于药物核酸传递的脂质基纳米颗粒的设计
Monique C P Mendonça,Ayse Kont,Piotr S Kowalski et al.
Monique C P Mendonça et al.
The successful development of nonviral delivery systems for nucleic acids has been reported extensively over the past number of years. Among them, lipid-based nanoparticles (LNPs) represent the most advanced platform. This review provides a...