Hossein Omidian,Jafar Razmara,Sepideh Parvizpour et al.
Hossein Omidian et al.
The life cycle of a drug begins with discovery and ends with its disposal. Drug discovery companies, drug manufacturers, regulatory agencies, suppliers, pharmacies, patients, healthcare providers, and many more are involved in this process....
Multidrug nanoformulations of vitamin D, anandamide and melatonin as a synergistic treatment for vascular inflammation [0.03%]
维生素D、安酰胺和褪黑素的纳米药物配方作为血管炎症协同治疗的新策略
Virna Margarita Martín Giménez,Russel J Reiter,Walter Manucha
Virna Margarita Martín Giménez
Longitudinal ctDNA profiling in precision oncology and immunο-oncology [0.03%]
精准肿瘤学和免疫肿瘤学的纵向ctdna分析
Panagiotis Filis,Ioannis Kyrochristos,Efterpi Korakaki et al.
Panagiotis Filis et al.
Serial analysis of circulating tumor DNA (ctDNA) over the disease course is emerging as a prognostic, predictive and patient-monitoring biomarker. In the metastatic setting, several multigene ctDNA assays have been approved or recommended b...
Manasi S Pote,Rajesh N Gacche
Manasi S Pote
Of the many multidrug resistance (MDR) mechanisms, the ATP binding cassette (ABC) transporters expelling drug molecules out of cells is a major culprit in limiting the efficacy of present-day anticancer drugs. The present review offers an u...
Vincent Tse,Liang Schweizer
Vincent Tse
Biotech start-ups often begin as domestic companies relying on local resources and talent, but this approach might not be effective in achieving rapid growth and long-term success, particularly for developing new therapeutics that require s...
API co-crystals - Trends in CMC-related aspects of pharmaceutical development beyond solubility [0.03%]
药物开发中超越溶解度的CMC相关方面的发展趋势-API共晶体
Axel Becker
Axel Becker
Whereas pharmaceutical co-crystals are widely described as tool to improve solubility and dissolution behavior of poorly soluble drugs, so far less focus has been on their potential role to facilitate pharmaceutical manufacturability. This ...
Role of innovation in pharmaceutical regulation: A proposal for principles to evaluate EU General Pharmaceutical Legislation from the innovator perspective [0.03%]
从创新者的角度评估欧盟《通用制药法》的原理：创新在药品监管中的作用提案
Inkatuuli Heikkinen,Sini Eskola,Virginia Acha et al.
Inkatuuli Heikkinen et al.
Because the EU General Pharmaceutical Legislation is under review, the EFPIA Innovation Board developed evaluation principles for the policy proposals and key considerations on how the regulatory framework can support innovation while ensur...
Academic drug discovery in an age of research abundance, and the curious case of chemical screens toward drug repositioning [0.03%]
科研过剩条件下的学术药物发现及针对药物再定位的化合物筛选的特殊案例
Alessandro Datti
Alessandro Datti
High-throughput screening (HTS) is a vaunted technology in drug discovery, and drug repositioning a celebrated strategy with famous examples of successful stories; however, repositioned drugs have primarily resulted from serendipitous obser...
Sadhana Tripathi,Neelam Sharma,Leimarembi Devi Naorem et al.
Sadhana Tripathi et al.
Over the years, numerous vaccines have been developed against viral infections; however, a complete database that provides comprehensive information on viral vaccines has been lacking. In this review, along with our freely accessible databa...
Inflammation, stress and depression: An exploration of ketamine's therapeutic profile [0.03%]
炎症、压力和抑郁：ketamine治疗谱系的探索研究
Jenessa N Johnston,Maximillian S Greenwald,Ioline D Henter et al.
Jenessa N Johnston et al.
Well-established animal models of depression have described a proximal relationship between stress and central nervous system (CNS) inflammation - a relationship mirrored in the peripheral inflammatory biomarkers of individuals with depress...