Small pharma vendor management practices in clinical trials: A case study within Faron Pharmaceuticals [0.03%]
福龙制药公司的临床试验中小型药品供应商管理实践案例研究
Joab Williamson,Juho Jalkanen,Maria Lahtinen
Joab Williamson
Many small pharmaceutical companies find that they lack the resources, knowledge and expertise of the regulatory landscape for adequate vendor management in clinical trials, making the organization vulnerable. Recent research suggests that ...
AlphaFold, allosteric, and orthosteric drug discovery: Ways forward [0.03%]
AlphaFold、别构和正构药物发现：未来之路
Ruth Nussinov,Mingzhen Zhang,Yonglan Liu et al.
Ruth Nussinov et al.
Drug discovery is arguably a highly challenging and significant interdisciplinary aim. The stunning success of the artificial intelligence-powered AlphaFold, whose latest version is buttressed by an innovative machine-learning approach that...
Kinase inhibitors: Opportunities for small molecule anticancer immunotherapies [0.03%]
激酶抑制剂：小分子抗肿瘤免疫治疗的机会与前景
Ava Safaroghli-Azar,Fatemeh Emadi,Jimma Lenjisa et al.
Ava Safaroghli-Azar et al.
As the fifth pillar of cancer treatment, immunotherapy has dramatically changed the paradigm of therapeutic strategies by focusing on the host's immune system. In the long road of immunotherapy development, the identification of immune-modu...
Therapeutic strategies of small molecules in the microbiota-gut-brain axis for alcohol use disorder [0.03%]
靶向菌群-肠-脑轴的小分子治疗酒精使用障碍的新策略
Lushuang Xie,Wiramon Rungratanawanich,Qiang Yang et al.
Lushuang Xie et al.
The microbiota-gut-brain axis (MGBA) is important in maintaining the structure and function of the central nervous system (CNS) and is regulated by the CNS environment and signals from the peripheral tissues. However, the mechanism and func...
Aptamers and nanobodies as alternatives to antibodies for ligand-targeted drug delivery in cancer [0.03%]
适配体和纳米抗体在癌症配体靶向药物递送中作为抗体的替代品
Dhruv Sanjanwala,Vandana Patravale
Dhruv Sanjanwala
Targeted drug delivery (TDD) is the selective delivery of a therapeutic agent specifically to the site of action to avoid adverse effects and systemic toxicity and to reduce the dose required. Ligand TDD or active TDD involves using a ligan...
Komal Kalani,Poonam Chaturvedi,Pankaj Chaturvedi et al.
Komal Kalani et al.
Mitochondrial function is essential for maintaining neuronal integrity, because neurons have a high energy demand. Neurodegenerative diseases, such as Alzheimer's disease (AD), are exacerbated by mitochondrial dysfunction. Mitochondrial aut...
CIPDB: A biological structure databank for studying cation and π interactions [0.03%]
离子与π数据库(CIPDB)：研究离子和π相互作用的生物学结构数据库
Jing-Fang Yang,Fan Wang,Meng-Yao Wang et al.
Jing-Fang Yang et al.
As major forces for modulating protein folding and molecular recognition, cation and π interactions are extensively identified in protein structures. They are even more competitive than hydrogen bonds in molecular recognition, thus, are vi...
Native mass spectrometry-directed drug discovery: Recent advances in investigating protein function and modulation [0.03%]
基于原位质谱的药物发现近期进展：研究蛋白质功能及作用效应
Francesco Fiorentino,Dante Rotili,Antonello Mai
Francesco Fiorentino
Native mass spectrometry (nMS) is a biophysical method for studying protein complexes and can provide insights into subunit stoichiometry and composition, protein-ligand, and protein-protein interactions (PPIs). These analyses are made poss...
Eva C Maciejewski,Michele A Basso,Cory T Miller et al.
Eva C Maciejewski et al.
Randomized controlled trials do not always fit the purpose: A science-based response to Venetis and Mol's editorial on biosimilars of follitropin alfa [0.03%]
随机对照试验并不总是符合目的：对Venetis和Mol关于重组人促卵泡激素类似物的科学基于药物评论的回答
Fernando de Mora,Colin M Howles
Fernando de Mora