Polymeric micelles as potent islet amyloid inhibitors: Current advances and future perspectives [0.03%]
聚合物胶束作为强大的胰岛淀粉样蛋白抑制剂：当前进展和未来展望
Jaskiran Kaur,Monica Gulati,Indu Pal Kaur et al.
Jaskiran Kaur et al.
Diabetes mellitus (DM) has become one of the most prevalent diseases across the globe, mainly because of the inability of existing treatment strategies to target its root cause (i.e., pancreatic β cell damage). Polymeric micelles (PMs) hav...
Fatty acids as histone deacetylase inhibitors: Old biochemistry tales in a new life sciences town [0.03%]
脂肪酸作为组蛋白去乙酰化酶抑制剂：老生化学故事在新生命科学领域的发展
Meran Keshawa Ediriweera
Meran Keshawa Ediriweera
Histone acetylation is a key epigenetic event. Although the keywords fatty acids, histones, and histone acetylation have a long history in biochemistry, these topics continue to attract much attention among researchers. The acetylation of h...
Georgina C Wilkins,Katherine Lanyi,Alexander Inskip et al.
Georgina C Wilkins et al.
Advanced therapy medicinal products (ATMPs) are innovative biological products categorised as either gene, somatic cell, tissue-engineered or combined therapies. As of March 2022, 12 ATMPs are marketed in the EU and UK. We identified 482 un...
Pulmonary artery smooth muscle cell phenotypic switching: A key event in the early stage of pulmonary artery hypertension [0.03%]
肺动脉平滑肌细胞表型转化在肺动脉高压发病早期的关键作用
Binghao Ma,Yuanyuan Cao,Jia Qin et al.
Binghao Ma et al.
Pulmonary arterial hypertension (PAH) is a currently incurable pulmonary vascular disease. Since current research on PAH is mainly aimed at the middle and late stages of disease progression, no satisfactory results have been achieved. This ...
Exploring human CYP4 enzymes: Physiological roles, function in diseases and focus on inhibitors [0.03%]
探索人类CYP4酶：生理作用、疾病功能和重点抑制剂
Manzhen Zhou,Junda Li,Jinyi Xu et al.
Manzhen Zhou et al.
The cytochrome P450 (CYP)4 family of enzymes are monooxygenases responsible for the ω-oxidation of endogenous fatty acids and eicosanoids and play a crucial part in regulating numerous eicosanoid signaling pathways. Recently, CYP4 gained a...
Dysbiosis versus diabesity: Pathological signaling and promising therapeutic strategies [0.03%]
菌群失调与糖尿病肥胖症：病理信号及有前景的治疗策略
Arun K Sharma,Akash Sharma,Samridhi Lal et al.
Arun K Sharma et al.
A healthy life depends on the inseparable relationship between a host and the gut microbiota. A healthy gut microbiota regulates intestinal integrity, whereas an unbalanced gut microbiota contributes to junctional remodeling and leads to dy...
Recent progress in targeting KRAS mutant cancers with covalent G12C-specific inhibitors [0.03%]
KRASG12C抑制剂的研究进展
Lala S Rathod,Pratap S Dabhade,Santosh N Mokale
Lala S Rathod
KRASG12C has been identified as a potential target in the treatment of solid tumors. One of the most often transformed proteins in human cancers is the small Kirsten rat sarcoma homolog (KRAS) subunit of GTPase, which is typically the oncog...
Juan L Paris,Lalitkumar K Vora,María José Torres et al.
Juan L Paris et al.
The incidence of allergies has been steadily increasing in recent years. Allergen-specific immunotherapy (AIT) represents the only approach capable of inducing long-term immune tolerance toward allergens. However, the clinical success of AI...
Harnessing personalized tailored medicines to digital-based data-enriched edible pharmaceuticals [0.03%]
从个性化药物到数字化数据丰富型可食用制药品
Mayank Handa,Obaid Afzal,Sarwar Beg et al.
Mayank Handa et al.
Tailoring drug products to personalized medicines poses challenges for conventional dosage forms. The prominent reason is the restricted availability of flexible dosage strengths in the market. Inappropriate dosage strengths lead to adverse...
Peptide modulators of cell migration: Overview, applications and future development [0.03%]
细胞迁移肽类调节剂：概览、应用及未来发展
Jasmin Gattringer,Christian W Gruber,Roland Hellinger
Jasmin Gattringer
Cell migration is a key physiological process in the development and homeostasis of multicellular organisms; errors in this complex system can trigger the development of cancer or inflammatory disorders. Therefore, modulating cell migration...