Shujie Zhao,Xujie Zhang,Edeildo Ferreira da Silva-Júnior et al.
Shujie Zhao et al.
Approved or licensed antiviral drugs have limited applications because of their drug resistance and severe adverse effects. By contrast, by stabilizing or destroying the viral capsid, compounds known as capsid modulators prevent viral repli...
COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease [0.03%]
针对SARS-CoV-2主要蛋白酶的小分子药物开发以应对新型冠状肺炎疫情
Thales Kronenberger,Stefan A Laufer,Thanigaimalai Pillaiyar
Thales Kronenberger
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the causative factor behind the 2019 global coronavirus pandemic (COVID-19). The main protease, known as Mpro, is encoded by the viral genome and is essential for viral rep...
Role of SIRT3 in mitochondrial biology and its therapeutic implications in neurodegenerative disorders [0.03%]
SIRT3在线粒体生物学中的作用及其在神经退行性疾病治疗中的意义
Yogesh Mishra,Ravinder K Kaundal
Yogesh Mishra
Sirtuin 3 (SIRT3), a mitochondrial deacetylase expressed preferentially in high-metabolic-demand tissues including the brain, requires NAD+ as a cofactor for catalytic activity. It regulates various processes such as energy homeostasis, red...
Senolytics: Opening avenues in drug discovery to find novel therapeutics for Parkinson's Disease [0.03%]
森尼奇药物发现的新途径——帕金森病的新型治疗药物
Violina Kakoty,Sarathlal Kalarikkal Chandran,Monica Gulati et al.
Violina Kakoty et al.
Aging is one of the major risk factors for most neurodegenerative disorders including Parkinson's disease (PD). More than 10 million people are affected with PD worldwide. One of the predominant factors accountable for progression of PD pat...
Promise of dostarlimab in cancer therapy: Advancements and cross-talk considerations [0.03%]
dostarlimab在癌症治疗中的前景：进展和相互作用考虑因素
Quratulain Babar,Ayesha Saeed,Sivasubramanian Murugappan et al.
Quratulain Babar et al.
In recent years, immunotherapy for cancer treatment using monoclonal antibodies has shown clinical success, particularly with programmed cell death protein 1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1). Dostarlimab, an immune ch...
Evaluation of clinical trial designs for novel anticancer drugs in China: A cohort study of drugs approved between 2015 and 2021 [0.03%]
2015年至2021年中国批准的抗肿瘤药物临床试验设计评价：一项队列研究
Xingxian Luo,Qixiang Guo,Xin Du et al.
Xingxian Luo et al.
China has greatly facilitated the approval of many novel anticancer drugs since the drug regulatory reform in 2015. Here, we review the clinical trial designs used in pivotal clinical trials for approved anticancer agents in China from 2015...
Demystifying the potential of inhibitors targeting DNA topoisomerases in unicellular protozoan parasites [0.03%]
解密DNA拓扑异构酶抑制剂在单细胞原生动物寄生虫中的潜力
Swati Lamba,Amit Roy
Swati Lamba
DNA topoisomerases are a group of enzymes omnipresent in all organisms. They maintain the DNA topology during replication, repair, recombination, and transcription. However, the structure of topoisomerase in protozoan parasites differs sign...
Advances in receptor chromatography for drug discovery and drug-receptor interaction studies [0.03%]
受体亲和色谱在药物发现及药受体相互作用研究中的新进展
Jia Fu,Wei Qin,Lu-Qi Cao et al.
Jia Fu et al.
Receptor chromatography involves high-throughput separation and accurate drug screening based on specific drug-receptor recognition and affinity, which has been widely used to screen active compounds in complex samples. This review summariz...
Henri Chédotal,Dilip Narayanan,Katrine Povlsen et al.
Henri Chédotal et al.
Tumor necrosis factor (TNF) is a pleiotropic cytokine with a major role in immune system homeostasis and is involved in many inflammatory and autoimmune diseases, such as rheumatoid arthritis (RA), psoriasis, Alzheimer's disease (AD), and m...
Potential of nanocarriers using ABC transporters for antimicrobial resistance [0.03%]
利用ABC转运蛋白的纳米载体对抗微生物耐药性的潜力
Ragini Amarnani,Amey Revdekar,Bhagyashree Salvi et al.
Ragini Amarnani et al.
Some existing therapies such as antimicrobial regimens, drug combinations, among others, are employed for the treatment of infections that are a threat to the healthcare industry owing to low drug efficacy, increasing dosage regimes, mutati...