Nabab Khan,Garima Slathia,Kajal Kaliya et al.
Nabab Khan et al.
Covalent organic frameworks (COFs) have gained tremendous interest in cancer therapy owing to their multifunctional properties, such as biocompatibility, tunable cavities, excellent crystallinity, ease of modification/functionalization, and...
Nanostructured organic photosensitizer aggregates in disease phototheranostics [0.03%]
疾病光诊疗中的纳米结构有机光敏剂聚集现象
Maochao Zheng,Qianqian Yang,Chao Lu et al.
Maochao Zheng et al.
Aggregate science provides promising opportunities for the discovery of novel disease phototheranostics. Under the guidance of aggregology and the Jablonski energy level diagram, photosensitizer aggregates with tunable photophysical propert...
Nanomedicine-mediated therapeutic approaches for pulmonary arterial hypertension [0.03%]
纳米医学介导的肺动脉高压治疗策略
Elaheh Mirhadi,Prashant Kesharwani,Thomas P Johnston et al.
Elaheh Mirhadi et al.
Nanomedicine has emerged as a field in which there are opportunities to improve the diagnosis, treatment and prevention of incurable diseases. Pulmonary arterial hypertension (PAH) is known as a severe and fatal disease affecting children a...
Scope of Wnt signaling in the precise diagnosis and treatment of breast cancer [0.03%]
Wnt信号通路在乳腺癌精准诊疗中的作用范畴
Dilip K Patel,Roohi Kesharwani,Amita Verma et al.
Dilip K Patel et al.
Malignant breast cancers are responsible for a growing number of deaths among women globally. The latest research has demonstrated that Wnt signaling is pivotal in this disease, regulating a safe microenvironment for the growth and prolifer...
Expanding therapeutic potential of Bdellovibrio bacteriovorus against multidrug-resistant pathogens [0.03%]
扩大 Bdellovibrio bacteriovorus 治疗多重耐药病原体的潜力
Camila Maurmann de Souza,Osmel Fleitas Martínez,Harry Morales Duque et al.
Camila Maurmann de Souza et al.
Novel treatments toward Gram-negative bacteria are urgently needed to prevent even higher mortality levels associated with resistant bacterial infections. Predatory bacteria have been studied as a new type of treatment against pathogenic ba...
Kevin Roe
Kevin Roe
Several fungal pathogens are becoming resistant to conventional fungal infection treatments, and some fungal pathogens have become multidrug-resistant. Alternative treatments include fungal vaccines, conventional or synthetic monoclonal ant...
Carbon nanosheets to unravel the production of bioactive compounds from microalgae: A robust approach in drug discovery [0.03%]
碳纳米片揭示了从微藻中产生生物活性化合物的方法：药物发现中的一个有力方法
Aakanksha Agarwal,Abhyavartin Selvam,Misba Majood et al.
Aakanksha Agarwal et al.
The conglomeration of active pharmaceutical ingredients (APIs) has influenced the development of life-saving drugs. These APIs are customarily synthetic products, albeit with adverse side effects. Thus, to overcome the bottlenecks associate...
Driving the degradation of oncofusion proteins for targeted cancer therapy [0.03%]
驱动致癌融合蛋白的降解以靶向癌症治疗
Xingya Zhang,Yingqian Chen,Bo Yang et al.
Xingya Zhang et al.
Oncofusion proteins drive the development of about 16.5% of human cancers, functioning as the unique pathogenic factor in some cancers. The targeting of oncofusion proteins is an attractive strategy to treat malignant tumors. Recently, trig...
Morphoceuticals: Perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer and aging [0.03%]
药物解剖学：重塑药物研发以治疗再生医学、癌症和衰老疾病的新视角
Léo Pio-Lopez,Michael Levin
Léo Pio-Lopez
Morphoceuticals are a new class of interventions that target the setpoints of anatomical homeostasis for efficient, modular control of growth and form. Here, we focus on a subclass: electroceuticals, which specifically target the cellular b...
Jean B Bertoldo,Simon Müller,Stefan Hüttelmaier
Jean B Bertoldo
RNA-binding proteins (RBPs) are crucial players in tumorigenesis and, hence, promising targets in cancer drug discovery. However, they are largely regarded as 'undruggable', because of the often noncatalytic and complex interactions between...