Pharmacomicrobiomics and the gut-brain axis: microbial modulation of drug response in brain disorders [0.03%]
药微生物组学和脑-肠轴：肠道菌群对大脑疾病中药物反应的调节作用
Anitha Kuttiappan,Murugesan Vanangamudi,Sumel Ashique et al.
Anitha Kuttiappan et al.
Pharmacomicrobiomics is the study of how the gut microbiota affects the metabolism, efficacy, and safety of drugs. Gut microbes play a key role in neurochemical communication along the gut-brain axis and can alter responses to neuroactive m...
Daniel O&#x;Keeffe
Daniel O&#x;Keeffe
Microbial dysbiosis in metabolic disorders: linking epigenomic regulation and pathological mechanisms [0.03%]
代谢紊乱中的微生物菌群失调：表观基因调控与病理机制间的关联研究
Arun K Sharma,Md Sayeed Akhtar,Khalid Orayj et al.
Arun K Sharma et al.
Microbial dysbiosis critically contributes to metabolic disorders by altering host-microbiome interactions and disrupting metabolic homeostasis. This review highlights how dysbiosis-derived metabolites, including short-chain fatty acids (SC...
Advances in siRNA and synbiotic therapies for colorectal cancer: a molecular and microbiota perspective [0.03%]
从分子和微生物角度展望siRNA和合生元疗法在结直肠癌治疗中的进展
Monika Vishwakarma,K Anitha,Sumel Ashique et al.
Monika Vishwakarma et al.
Colorectal cancer (CRC) remains a major global health challenge, with rising incidence and mortality despite advances in conventional therapies, often limited by recurrence, toxicity and drug resistance. siRNA-based therapeutics offer a pre...
From bespoke CRISPR to scalable access: regulating N-of-1 medicines as platforms [0.03%]
从定制型CRISPR到可及性扩容：将一类药物作为平台进行监管
Charles H Jones,Mikael Dolsten
Charles H Jones
Differential immunogenicity of biosimilar monoclonal antibodies: overrated and overemphasized? [0.03%]
生物类似物单克隆抗体的免疫原性差异：过度评价了吗？
Uwe Gudat
Uwe Gudat
Monoclonal antibodies (mAbs), as biologics and biosimilars, have revolutionized patient care for certain chronic inflammatory and oncological conditions over the past decade. Immunogenicity against these biologic therapeutics is not uncommo...
Ariba Khan,Jai Vengurlekar,Amol Gholap et al.
Ariba Khan et al.
Mannans are a major component of gymnosperm wood and are found in the seed of various non-leguminous plants. This group of polymers have received great attention because of their physico-chemical properties, such as their viscosity, polymer...
Benign-by-design chemistry: Reinventing ligand-based drug design at the edge of AI [0.03%]
以AI为边界的ligand为基础的药物设计的良性再发明：从头开始的化学设计方法
Edgar López-López,Pamela I Hernández-Estrada,Angel N Toto-Vazquez et al.
Edgar López-López et al.
Ligand-based drug design (LBDD) has long driven therapeutic innovation; however, its traditional potency-centered paradigm often oversimplifies biological complexity. Advances in artificial intelligence (AI) now enable multiobjective strate...
Ligand trapping as a key mechanism governing drug residence time, binding affinity, and potency [0.03%]
配体陷阱在药物作用时间、结合亲和力和药效强度方面的关键机制研究
Danislav S Spassov
Danislav S Spassov
Estimating binding affinity and potency is vital for the design of high-affinity compounds. Protein-ligand interactions are accompanied by conformational changes, resulting in complex kinetic behavior that influences drug activity and poten...
Health and Medical Research in Australia I: A Long-term Investment that Drives Innovation and Endogenous Growth [0.03%]
澳大利亚卫生和医学研究(I):一项驱动创新和内生增长的长期投资政策
Levon M Khachigian
Levon M Khachigian