IdopNetworks: How to infer the individualized genetic architecture of genomics for precision medicine [0.03%]
天择网络：如何推断个体化基因组架构以实现精准医疗
Shuang Wu,Wenqi Pang,Yu Wang et al.
Shuang Wu et al.
Genome-wide association studies suffer from two major limitations - reductionist statistics and population-level averaging - both of which hinder actionable insights for precision medicine. To bridge these gaps, we introduce a statistical m...
Organoid-AI platforms need integrated governance in drug discovery [0.03%]
类器官与人工智能平台在药物发现中的综合治理需求不容忽视
Johnny Sakr
Johnny Sakr
Organoid-AI platforms are becoming decision systems in drug discovery, not just combined tools. They shape compound prioritisation, toxicity assessment, and programme progression. Yet governance often validates the biological model and the ...
Inorganic nanoparticles for diagnostics, drug delivery and therapy for solid tumors [0.03%]
用于固体肿瘤诊断、药物输送和治疗的无机纳米粒子
Lakshmi G Peetani,Swapna P Ganji,Ganji P Nagaraju
Lakshmi G Peetani
Solid tumors continue to be a major cause of mortality worldwide, with limitations in available therapies such as toxicity, nonspecificity, multidrug resistance and heterogeneity in the tumor microenvironment (TME). Inorganic nanoparticles ...
Wei Zhang,Yanli Wang,Darcy Tocci et al.
Wei Zhang et al.
Alzheimer's disease (AD) is the leading cause of dementia. It is characterized by amyloid and tau pathological hallmarks, accompanied by synaptic dysfunction, neuroinflammation, and progressive neuronal loss. Although amyloid-reducing antib...
From biologics to small-molecule modulators: The evolving landscape of interleukin-targeted therapeutics [0.03%]
从生物制剂到小分子调节剂：靶向白细胞介素药物的演变格局
Yiping Zhu,Qindi He,Yadong Chen et al.
Yiping Zhu et al.
The interleukin (IL) family, a crucial class of cytokines in immune regulation, orchestrates diverse biological processes, including immune response modulation, lymphocyte proliferation/differentiation and pathological mechanisms underlying...
Targeting the GLP-1 receptor pathways for dual management of obesity and depression [0.03%]
靶向GLP-1受体通路以同时治疗肥胖症和抑郁症
Ruchi Keswani,Shvetank Bhatt
Ruchi Keswani
Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), initially developed for the treatment of diabetes mellitus, are now widely used in obesity management. Obesity and depression are interconnected and share common biological pathw...
Dan Wu,Yuxuan Zhu,Mengjie Ye et al.
Dan Wu et al.
MYC, a multifunctional transcription factor overexpressed in cancers, has a crucial role in tumor initiation, maintenance, and progression. However, because of the lack of enzymatic activity and small molecule-binding sites, MYC has been co...
Maria J Falaguera,Tudor I Oprea,Jordi Mestres
Maria J Falaguera
In the past 25 years, drugs acting on multiple targets by design have accounted for around one-fifth of annual new approvals. Beyond primary targets, drugs also interact, usually unintentionally, with multiple secondary targets. Here, we pr...
From trial-and-error to inverse design: how AI is redefining drug delivery systems [0.03%]
从试错到逆向设计：人工智能如何重新定义药物输送系统
Sofía Blas-Gómez,Carlos Alonso-Moreno,Alberto Ocaña et al.
Sofía Blas-Gómez et al.
AI is transforming drug delivery system (DDS) design by enabling predictive modeling and inverse design strategies. Recent advances integrating machine learning, deep learning and physics-informed approaches have improved the ability to cap...
Critical evaluation of the key mediators causing life-threatening symptoms during human anaphylaxis [0.03%]
人体过敏性休克致死的关键介导因子评价
Thomas Boehm,Bernd Jilma
Thomas Boehm
Most pathophysiologically oriented anaphylaxis reviews list a plethora of mediators purportedly involved in symptom development during severe anaphylaxis. However, how many mediators are responsible for life-threatening anaphylaxis symptoms...