Interference of long noncoding RNAs in glioblastoma multiforme: key targets for next generation therapeutics [0.03%]
长非编码RNA在多形性胶质母细胞瘤中的干扰作用：下一代治疗的关键靶点
Soushruti Sarkar,Subhrangsu Chatterjee
Soushruti Sarkar
Being a highly aggressive primary brain tumor, glioblastoma multiforme (GBM) results in poor patient survival owing to its uncontrolled progression and resistance to standard therapies. Amidst these severe treatment failures, long noncoding...
Progress in allergen immunotherapy via advanced transdermal delivery routes [0.03%]
经皮给药途径在过敏免疫治疗中的进展
Ambreen Akhtar,Neenu Singh,Muhammad Sohail Arshad et al.
Ambreen Akhtar et al.
Food allergies, particularly peanuts and tree nut allergies, can trigger severe anaphylaxis, prompting the development of novel immunotherapies. Conventional allergen immunotherapies, including therapies delivered by oral, sublingual and ep...
Massyel S Martinez-Cortés,Carlos A Velázquez-Martínez,José L Medina-Franco
Massyel S Martinez-Cortés
Proteolysis-targeting chimeras (PROTACs) represent a transformative strategy in drug discovery, enabling the selective degradation of target proteins rather than merely inhibiting their activity. However, their structural complexity and dev...
Yongpan An,Ruixiao Li,Rui Zhang et al.
Yongpan An et al.
The aging kidney is both a prime target of age-related damage and an independent risk factor for renal diseases; as populations grow older, chronic kidney disease in the elderly has become a major emerging health threat. Over recent decades...
Smart Breathomics: future prospects for non-invasive respiratory disease detection using biomarkers in exhaled breath condensate [0.03%]
智能呼吸组学：利用呼出气冷凝液中的生物标志物进行非侵入性呼吸道疾病检测的前景展望
Mitali Sahu,Vikas Gurjar,Rohini Singh et al.
Mitali Sahu et al.
Smart Breathomics is redefining the field of non-invasive diagnostics in respiratory diseases through the analysis of exhaled breath condensate (EBC). Chronic respiratory diseases (CRDs) represent a significant global health burden and are ...
Huidan Dong,Yongkang Yuan,Binru Jia et al.
Huidan Dong et al.
Enzyme trafficking mediates intracellular enzyme transport and localization, which is pivotal for regulating enzymatic activity and maintaining cellular homeostasis. Its dysregulation is implicated in neurodegenerative diseases, cancer, and...
Leveraging artificial intelligence in tissue regenerative engineering via small-molecule libraries [0.03%]
基于小分子化合物库的人工智能组织再生工程研究
Fatemeh S Hosseini,Taraje Whitfield,Juan Mitchell et al.
Fatemeh S Hosseini et al.
Small molecules have emerged as a promising approach for regenerative engineering. Yet, the screening and creation of small-molecule libraries remain challenging for streamlining drug discovery. This challenge has fueled the demand for adva...
Engineering strategies and therapeutic applications of synthetic Notch (synNotch) receptors in cancer therapeutics [0.03%]
合成Notch（synNotch）受体在癌症治疗中的工程策略和治疗应用
Amol D Gholap,Jai R Vengurlekar,Navnath T Hatvate et al.
Amol D Gholap et al.
Synthetic Notch (synNotch) receptors have been developed as a novel approach to cell-based immunotherapy and will provide programmable, specific cancer treatments. Unlike existing fixed chimeric antigen receptor (CAR)-T cell therapies, synN...
Long-Can Mei,Han Xiao,Da-Wei Wang et al.
Long-Can Mei et al.
Farnesyltransferase (FTase) mediates Ras prenylation, a crucial activation step. Historically, farnesyltransferase inhibitors (FTIs) failed in Ras-driven cancers because of geranylgeranyltransferase I (GGTase I)-mediated alternative prenyla...
Therapeutic targeting of FZD receptor proteins with biologics in cancer [0.03%]
生物制剂在癌症中的治疗靶向作用于FZD受体蛋白
Issam Hmila,Vladimir L Katanaev
Issam Hmila
Wnt signaling plays key roles in the initiation, progression, and therapy resistance of various cancers. No drugs targeting this pathway are currently available, and several candidates have failed because they affected healthy tissues such ...