PHGDH: a metabolic switch in tumor drug resistance and a therapeutic target [0.03%]
PHGDH：肿瘤耐药的代谢调控开关及治疗靶点
Song-Song Shi,Si-Yi Chen,Wen Zhang et al.
Song-Song Shi et al.
Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the de novo serine biosynthesis pathway. Aberrant PHGDH overexpression has been observed in multiple malignancies and is closely associated with tumor progression, therap...
Therapeutic strategies for the fatty-acid-binding pocket of the spike protein: advances and perspectives [0.03%]
刺突蛋白脂肪酸结合区的药物研发策略：进展与展望
Wenwu Liu,Wenjie Liu,Zhuona Rong et al.
Wenwu Liu et al.
The trimeric spike protein plays a crucial part in the lifecycle of SARS-CoV-2 by facilitating viral entry. The SARS-CoV-2 spike protein harbors a fatty-acid-binding pocket (FABP) at the interface between two adjacent receptor-binding domai...
Digital twin approaches for interpretable side effect prediction in drug discovery [0.03%]
用于药物发现中可解释的副作用预测的数字孪生方法
András Ecker,Gergely Szabó,János Szalma et al.
András Ecker et al.
Artificial intelligence increasingly supports preclinical drug development although accurate, early prediction of side effects remains limited. Leading approaches rely on expert-derived features, unavailable in early discovery, or on chemic...
Artificial-intelligence-guided autophagy modulation and nanomedicine design for precision photodynamic cancer therapy [0.03%]
人工智能引导的自噬调控及纳米药物设计用于精准光动力癌症治疗
Donya Esmaeilpour,Saeid Ghavami,Ali Zarrabi et al.
Donya Esmaeilpour et al.
Cancer remains a major cause of death worldwide and current therapies are often limited by toxicity, resistance and poor tumor selectivity. Photodynamic therapy (PDT) offers spatiotemporally controlled cytotoxicity but its efficacy is const...
Antibody-drug conjugates: from efficacy testing to bioassay evaluation in modern drug development [0.03%]
抗体-药物偶联物：从疗效检测到生物测定在现代药物开发中的评估方法
Christine Koehler,Ulrike Herbrand,Marie-Soleil Piche et al.
Christine Koehler et al.
Antibody-drug conjugates (ADCs) have emerged as one of the fastest-growing therapeutic modalities in oncology and are expanding in other disease areas as well, with 15 FDA-approved ADCs and over 250 drugs in different stages of development....
Ferroptosis inhibitors: latest advances and therapeutic potential for pulmonary arterial hypertension [0.03%]
铁死亡抑制剂在肺动脉高压治疗中的最新进展及潜在作用
Wenhua Tan,Yuanbo Hu,Liqing Hu et al.
Wenhua Tan et al.
Pulmonary arterial hypertension (PAH) is a progressive, high-mortality disease with multifactorial pathology. Although current therapies primarily target vascular remodeling, single-pathway approaches often remain insufficient against its c...
Large language models for molecular design: bridging the gap between chemical syntax and biological semantics [0.03%]
大型语言模型在分子设计中的应用：化学语法和生物语义之间的桥梁
Yingjun Chen,Xinheng Guo,Weiwei Xue
Yingjun Chen
Large language models (LLMs) are bridging the gap between chemical syntax and biological semantics in early drug discovery. This review traces the evolution from sequence-based generative models to autonomous discovery systems. We analyze d...
Tracing the path of non-industry-driven medicine development for rare diseases through regulatory interactions at the European Medicines Agency [0.03%]
通过欧洲药品管理局的监管互动追溯罕见病非行业驱动药物开发之路
Noa Rosenberg,Carla E M Hollak,V A Haverhoek et al.
Noa Rosenberg et al.
Non-industry organizations, including academia, charities, and public institutes, increasingly contribute to rare disease medicine development. In this study, we reviewed orphan designations (ODs) granted between 2000 and 2022, comparing no...
Vasanthanathan Poongavanam,S Pauliina Turunen,Kristian Sandberg et al.
Vasanthanathan Poongavanam et al.
DNA-encoded libraries (DELs) combined with machine learning (ML) offer a powerful paradigm for hit identification. However, sequencing-derived enrichment data are inherently noisy and biased, often resulting in models that overfit to specif...
Ruth Nussinov,Clil Regev,Hyunbum Jang
Ruth Nussinov
Biomacromolecular condensates are membraneless compartments that form through the dynamic assembly of function-related macromolecules to perform specific functions, such as signaling and gene expression. They have crucial roles in disease, ...