Shaping national networks to improve patient access to advanced therapy medicinal products in Europe [0.03%]
在欧洲建立国家网络以改善患者接受先进治疗药物的途径
Joyce M Hoek,Mike Broeders,Juan Francisco Hernandez et al.
Joyce M Hoek et al.
Advanced therapy medicinal products (ATMPs) offer the potential to address unmet medical needs, yet ensuring sustainable patient access remains challenging. In response, national ATMP networks are being established across Europe to strength...
Jianyou Gu,Susan E Bates,Zhe-Sheng Chen
Jianyou Gu
Yashwardhan Ghanwatkar,Pankaj Rajdeo,Ram I Mahato
Yashwardhan Ghanwatkar
Oncology drug discovery remains limited by high attrition, slow experimental iteration and weak translation from preclinical models to clinical benefit. This review examines how AI is restructuring that process through three connected layer...
Antibacterial PROTACs: the road ahead for next-generation antibiotics? [0.03%]
下一代抗生素的抗菌PROTAC们：前方的道路在哪里？
Andrea Milelli,Simone Raimondi,Somayeh Asgharpour et al.
Andrea Milelli et al.
The discovery of antibiotics revolutionized modern medicine, enabling the treatment of once-deadly bacterial infections. However, the rise of antibiotic-resistant bacteria has severely limited their effectiveness, making antimicrobial resis...
Targeting kinases with DNA-encoded libraries: current landscape and future directions [0.03%]
DNA编码化合物库筛选激酶抑制剂的方法学进展及应用前景展望
Maria Staikopoulou,Haitham Hassan
Maria Staikopoulou
In this review, we summarise and analyse the structures and key characteristics of kinase inhibitors identified through DNA-encoded libraries (DELs) from 2009 to 2025. We focus on their chemical diversity, binding interactions and optimisat...
N-myristoyltransferases: structure, function, disease, and inhibitors [0.03%]
N-myristoy转移酶：结构、功能、疾病和抑制剂
Suyang Yao,Xiaofang Wang,Shuyu Liu et al.
Suyang Yao et al.
N-myristoyltransferases (NMTs) catalyze protein N-myristoylation, which regulates protein localization and function. Notably, NMT1 is overexpressed in multiple cancers and promotes cancer survival primarily through N-myristoylation of its s...
Natural language querying of biological databases with large language models [0.03%]
大型语言模型在生物数据库自然语言查询中的应用
Vladimir A Makarov,Oleg Stroganov,Laura I Furlong et al.
Vladimir A Makarov et al.
It is attractive to be able to query biological knowledge bases using natural language. Natural language queries are typically translated into structured queries using large language models (LLMs). Here we report the outcomes of a systemati...
Agnieszka Polak,Anna Zagaja,Mariola Drozd
Agnieszka Polak
Patient safety and the ethical frameworks governing clinical trials are crucial challenges in drug development. Historical analysis reveals that advances in pharmacology often occurred in the context of insufficient protection for vulnerabl...
Molecular fingerprints of drug-resistant epilepsy identified through liquid biopsy profiling [0.03%]
通过液体活检分析鉴定难治性癫痫的分子特征
Zainab Khalid,Sobia Tabassum,Iain Goodhall et al.
Zainab Khalid et al.
Nearly one-third of individuals with epilepsy exhibit resistance to antiseizure medications (ASMs). Proposed mechanisms underlying drug resistance include metabolic impairments within brain tissue, maladaptive axonal sprouting with synaptic...