Cytokines affecting CD4+T regulatory cells in transplant tolerance. II. Interferon gamma (IFN-γ) promotes survival of alloantigen-specific CD4+T regulatory cells [0.03%]
影响CD4+T调节细胞的细胞因子与移植耐受II干扰素γ(IFN-γ)促进抗原特异性CD4+T调节细胞的存活
Masaru Nomura,Suzanne J Hodgkinson,Giang T Tran et al.
Masaru Nomura et al.
CD4+T cells that transfer alloantigen-specific transplant tolerance are short lived in culture unless stimulated with specific-donor alloantigen and lymphocyte derived cytokines. Here, we examined if IFN-γ maintained survival of tolerance ...
Serum miRNAs as potential biomarkers for the bronchiolitis obliterans syndrome after lung transplantation [0.03%]
肺移植后作为气道阻塞综合症潜在生物标志物的血清微小核糖核酸分子检测
K Budding,M Rossato,E A van de Graaf et al.
K Budding et al.
Lung transplantation (LTx) is the last treatment for patients suffering from end-stage lung diseases. Survival post-LTx is hampered by the development of the bronchiolitis obliterans syndrome (BOS) and diagnosis is often late. Given the urg...
Clinical Trial
Transplant immunology. 2017 Jun:42:1-4. DOI:10.1016/j.trim.2017.04.002 2017
Antibody response to HBV vaccination on dialysis does not correlate with the development of deNovo anti-HLA antibodies after renal transplantation [0.03%]
透析患者对乙肝疫苗的抗体反应与肾移植后新发抗HLA抗体无关
Teresa Kauke,Maximilian Link,Markus Rentsch et al.
Teresa Kauke et al.
Background: Response to Hepatitis B virus (HBV) vaccination can be diminished in some (50-80%) but not all dialysis patients. We hypothesized, that the response to vaccination on dialysis may correlate with the developmen...
Non-neuronal neuropeptide Y and its receptors during acute rejection of rat pulmonary allografts [0.03%]
大鼠同种肺移植急性排斥反应中非神经肽YY及其受体的变化
Jessica Schmitz,Anna Zakrzewicz,Sigrid Wilker et al.
Jessica Schmitz et al.
This study tested the hypothesis that neuropeptide Y (NPY) and NPY receptors 1 (Y1) and 2 (Y2) participate in lung allograft rejection. Inflammation in grafts may include interaction between blood leukocytes and graft endothelial cells and ...
CD28 biomarker quantification and expression level profiles in CD4+ T-lymphocytes in solid organ transplantation [0.03%]
实体器官移植受者外周血CD4+T淋巴细胞CD28标志物的定量及表达谱分析
Francisco Boix,José Miguel Bolarín,Anna Mrowiec et al.
Francisco Boix et al.
The introduction of anti-calcineurin-based therapies has led to an increase in the one-year survival as well as graft function rates in patients undergoing solid organ transplantation (SOT). Nonetheless, early cellular acute rejection (EAR)...
Clinical Trial
Transplant immunology. 2017 Jun:42:9-17. DOI:10.1016/j.trim.2017.04.001 2017
Steroid free immunosuppression is associated with enhanced Th1 transcripts in kidney transplantation [0.03%]
无激素免疫抑制与肾脏移植中增强的Th1转录相关
Petra Hruba,Irena Tycova,Eva Krepsova et al.
Petra Hruba et al.
Background: Steroid avoidance in immunosuppression in kidney transplantation offers several metabolic advantages, however it is associated with higher early acute rejection rate. Cellular and molecular mechanisms of this ...
Randomized Controlled Trial
Transplant immunology. 2017 Jun:42:18-23. DOI:10.1016/j.trim.2017.03.001 2017
Anti-HLA-DQ antibodies are highly and independently related to the C1q-binding capacity of HLA antibodies [0.03%]
抗HLA-DQ抗体与补体C1q结合能力的独立相关性研究
José M Arreola-Guerra,Luis E Morales-Buenrostro,Julio Granados et al.
José M Arreola-Guerra et al.
The complement-binding capacity of anti-HLA antibodies (HLAabs) is recognized as a key pathogenic factor. The aim of this study is to describe the patient characteristics associated to the presence of C1q+ as well as those of the Abs per se...
Observational Study
Transplant immunology. 2017 Mar:41:10-16. DOI:10.1016/j.trim.2017.02.003 2017
C M Wortel,S Heidt
C M Wortel
While B cells are traditionally known for their roles in antibody production, antigen presentation and cytokine production, recent studies have highlighted the existence of B cells with regulatory properties, which have been termed Bregs, a...
Predictive value of gene expression profiling for long-term survival after heart transplantation [0.03%]
基因表达谱预测心脏移植后的长期生存价值
Buntaro Fujita,Emir Prashovikj,Uwe Schulz et al.
Buntaro Fujita et al.
Objectives: Identifying patients at risk for impaired long-term survival after heart transplantation (HT) remains a clinical challenge. The aim of this analysis was to investigate whether the gene expression profiling tes...
Late onset cytopenias following haematopoietic stem cell transplant associated with viral infection and cell specific antibodies [0.03%]
与病毒感染和细胞特异性抗体相关的造血干细胞移植后迟发型血细胞减少症
Geoff Lucas,Steven Culliford,Nina Bendukidze et al.
Geoff Lucas et al.
This report describes a patient who received an allogeneic haematopoietic stem cell transplant and who, following a viral infection, developed late onset cytopenias associated with antibodies against red cells, platelets and granulocytes. I...
Case Reports
Transplant immunology. 2017 Mar:41:32-36. DOI:10.1016/j.trim.2017.02.002 2017